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Molecular Biology

D-Index
53
Citations
15822
World Ranking
2362
National Ranking
158

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Ana Pombo is affiliated with Humboldt-Universität zu Berlin in Germany. Their research expertise lies primarily in the field of Biochemistry, Genetics and Molecular Biology with a strong emphasis on Molecular Biology, Plant Science, Genetics, Biophysics, and Cell Biology.

Their scientific contributions encompass a range of topics, notably:

  • Genomics and Chromatin Dynamics
  • Chromosomal and Genetic Variations
  • Epigenetics and DNA Methylation
  • RNA Research and Splicing
  • Single-cell and spatial transcriptomics
  • Genetic Mapping and Diversity in Plants and Animals
  • RNA modifications and cancer

Ana Pombo has published extensively, with a considerable number of works appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature, Nature Methods, Aurum Revista Multidisciplinar, and Science.

Selected recent papers include:

  • Cell-type specialization is encoded by specific chromatin topologies, 2021, Nature
  • LifeTime and improving European healthcare through cell-based interceptive medicine, 2020, Nature
  • Comparison of the Hi-C, GAM and SPRITE methods using polymer models of chromatin, 2021, Nature Methods
  • A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation, 2022, Science
  • Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C, 2023, Nature Methods

Their frequent collaborators include researchers such as Alexander Kukalev, Rieke Kempfer, Mario Nicodemi, Ibai Irastorza-Azcárate, and Simona Bianco, reflecting a collaborative network across multiple studies and disciplines.

Ana Pombo has been recognized as a Member of the European Molecular Biology Organization (EMBO), an affiliation indicating active participation in the broader molecular biology community.

Best Publications

  • Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells.

    Dean A. Jackson;Ana Pombo

  • Intermingling of Chromosome Territories in Interphase Suggests Role in Translocations and Transcription-Dependent Associations

    Miguel R Branco;Ana Pombo

  • Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

    Julie K. Stock;Sara Giadrossi;Miguel Casanova;Emily Brookes

  • Complex multi-enhancer contacts captured by genome architecture mapping

    Robert A. Beagrie;Antonio Scialdone;Markus Schueler;Dorothee C. A. Kraemer

  • Formation of new chromatin domains determines pathogenicity of genomic duplications

    Martin Franke;Martin Franke;Daniel M. Ibrahim;Guillaume Andrey;Wibke Schwarzer

  • Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

    Erik Arner;Carsten O. Daub;Kristoffer Vitting-Seerup;Robin Andersson

  • Three-dimensional genome architecture: players and mechanisms

    Ana Pombo;Niall Dillon

  • Complexity of chromatin folding is captured by the strings and binders switch model

    Mariano Barbieri;Mita Chotalia;James Fraser;Liron-Mark Lavitas

  • Active RNA polymerases are localized within discrete transcription "factories' in human nuclei.

    F.J. Iborra;A. Pombo;D.A. Jackson;P.R. Cook

  • Dendritic Cells Interact Directly with Naive B Lymphocytes to Transfer Antigen and Initiate Class Switching in a Primary T-Dependent Response

    Michelle Wykes;Ana Pombo;Chris Jenkins;G. Gordon MacPherson

  • Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2

    Aditi Kanhere;Keijo Viiri;Carla C. Araújo;Jane Rasaiyaah

  • Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

    Huy Quang Le;Sushmita Ghatak;Ching-Yan Chloé Yeung;Frederik Tellkamp

  • Methods for mapping 3D chromosome architecture.

    Rieke Kempfer;Ana Pombo;Ana Pombo

  • Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation

    James Fraser;Carmelo Ferrai;Carmelo Ferrai;Andrea M Chiariello;Markus Schueler

  • Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

    David Landeira;Stephan P A Sauer;Raymond Poot;Maria Dvorkina

  • FANTOM5 CAGE profiles of human and mouse samples

    Shuhei Noguchi;Takahiro Arakawa;Shiro Fukuda;Masaaki Furuno

  • Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs

    Emily Brookes;Inês de Santiago;Daniel Hebenstreit;Kelly J. Morris

  • Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III.

    Ana Pombo;Dean A. Jackson;Michael Hollinshead;Zhengxin Wang

  • LOCALIZATION OF A PUTATIVE TRANSCRIPTIONAL REGULATOR (ATRX) AT PERICENTROMERIC HETEROCHROMATIN AND THE SHORT ARMS OF ACROCENTRIC CHROMOSOMES

    T. L. McDowell;R. J. Gibbons;H. Sutherland;D. M. O’Rourke

  • Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division

    Cheok‐Man Chow;Andrew Georgiou;Henrietta Szutorisz;Alexandra Maia e Silva

Frequent Co-Authors

Peter R. Cook
Peter R. Cook University of Oxford
Haruhiko Koseki
Haruhiko Koseki RIKEN Center for Integrative Medical Sciences
John C. Marioni
John C. Marioni European Bioinformatics Institute
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Alistair R. R. Forrest
Alistair R. R. Forrest Harry Perkins Institute of Medical Research
Frank Brombacher
Frank Brombacher University of Cape Town

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