World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
62
Citations
15215
World Ranking
2853
National Ranking
79

Overview

François Lépine is affiliated with the Institut National de la Recherche Scientifique in Canada, where their research spans multiple fields intersecting biology and computer science. Their work largely focuses on molecular biology, molecular medicine, and computer networks and communications.

The scientist has contributed notably to research on bacterial biofilms and quorum sensing, antibiotic resistance in bacteria, and bacterial genetics and biotechnology. Their investigations also encompass distributed systems and fault tolerance, advanced data storage technologies, advanced database systems and queries, and cystic fibrosis research advances.

Among recent publications are the following papers:

  • Tackling Recalcitrant Pseudomonas aeruginosa Infections in Critical Illness via Anti-virulence Monotherapy, 2022, Nature Communications
  • Wait-Free CAS-Based Algorithms: The Burden of the Past, 2021, Leibniz-Zentrum für Informatik (Schloss Dagstuhl)
  • Tackling Recalcitrant Pseudomonas aeruginosa Infections In Critical Illness via Anti-virulence Monotherapy, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • Le Lyon-Turin, un lien vital sous les Alpes qui se fait attendre, 2023, Administration

These papers reflect collaborative efforts with frequent co-authors, including Vijay Kumar Singh, Marianna Almpani, Damien Maura, Tomoe Kitao, and Livia Ferrari.

The research outputs have been published in several venues including:

  • Nature Communications
  • Leibniz-Zentrum für Informatik (Schloss Dagstuhl)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Administration

Lépine's diverse research portfolio covers both experimental and theoretical approaches, combining expertise in biochemical and genetic studies with advances in computer science related to networks and data systems. Through this interdisciplinary approach, the scientist investigates how bacterial behavior and resistance mechanisms impact medical treatments, especially in critical illness contexts such as cystic fibrosis, while also addressing challenges in distributed computing and algorithm design.

Best Publications

  • Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

    Dao Nguyen;Amruta Joshi-Datar;Francois Lepine;Elizabeth Bauerle

  • Rhamnolipids: diversity of structures, microbial origins and roles

    Ahmad Mohammad Abdel-Mawgoud;François Lépine;Eric Déziel

  • Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication.

    Eric Déziel;François Lépine;Sylvain Milot;Jianxin He

  • rhlA is required for the production of a novel biosurfactant promoting swarming motility in Pseudomonas aeruginosa: 3-(3-hydroxyalkanoyloxy)alkanoic acids (HAAs), the precursors of rhamnolipids.

    Eric Déziel;François Lépine;Sylvain Milot;Richard Villemur

  • Production of rhamnolipids by Pseudomonas aeruginosa

    Gloria Soberón-Chávez;François Lépine;Eric Déziel

  • The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones.

    Eric Déziel;Suresh Gopalan;Anastasia P. Tampakaki;François Lépine

  • Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa

    Lucas R. Hoffman;Éric Déziel;David A D'Argenio;François Lépine

  • Biosurfactant production by a soil pseudomonas strain growing on polycyclic aromatic hydrocarbons.

    Éric Déziel;Gilles Paquette;Richard Villemur;François Lépine

  • MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands

    Gaoping Xiao;Eric Déziel;Eric Déziel;Jianxin He;François Lépine

  • Liquid chromatography/mass spectrometry analysis of mixtures of rhamnolipids produced by Pseudomonas aeruginosa strain 57RP grown on mannitol or naphthalene.

    Éric Déziel;François Lépine;Danielle Dennie;Daniel L Boismenu

  • Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa

    François Lépine;Sylvain Milot;Eric Déziel;Jianxin He

  • Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2.

    Michael A. Bachman;Jennifer E. Oyler;Samuel H. Burns;Mélissa Caza

  • Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

    Mélissa Starkey;François Lépine;Damien Maura;Arunava Bandyopadhaya

  • The Desulfitobacterium genus

    Richard Villemur;Martin Lanthier;Réjean Beaudet;François Lépine

  • Burkholderia thailandensis harbors two identical rhl gene clusters responsible for the biosynthesis of rhamnolipids

    Danielle Dubeau;Eric Déziel;Donald E Woods;François Lépine

  • Inhibitors of pathogen intercellular signals as selective anti-infective compounds.

    Biliana Lesic;François Lépine;Eric Déziel;Jiangwen Zhang

  • Self-produced extracellular stimuli modulate the Pseudomonas aeruginosa swarming motility behaviour.

    Julien Tremblay;Anne-Pascale Richardson;François Lépine;Eric Déziel

  • Mass spectrometry monitoring of rhamnolipids from a growing culture of Pseudomonas aeruginosa strain 57RP.

    Éric Déziel;François Lépine;Sylvain Milot;Richard Villemur

  • Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1

    Alexander Zaborin;Kathleen Romanowski;Svetlana Gerdes;Christopher Holbrook

  • Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa.

    Olga Zaborina;Francois Lepine;Gaoping Xiao;Vesta Valuckaite

  • Isolation and characterization of Desulfitobacterium frappieri sp. nov., an anaerobic bacterium which reductively dechlorinates pentachlorophenol to 3-chlorophenol

    B. Bouchard;R. Beaudet;R. Villemur;G. McSWEEN

  • Burkholderia pseudomallei, B. thailandensis, and B. ambifaria Produce 4-Hydroxy-2-Alkylquinoline Analogues with a Methyl Group at the 3 Position That Is Required for Quorum-Sensing Regulation

    Ludovic Vial;François Lépine;Sylvain Milot;Marie-Christine Groleau

Frequent Co-Authors

Eric Déziel
Eric Déziel Institut National de la Recherche Scientifique
Laurence G. Rahme
Laurence G. Rahme Harvard University
Ronald G. Tompkins
Ronald G. Tompkins Harvard University
Charles M. Dozois
Charles M. Dozois Institut National de la Recherche Scientifique
Michael N. Mindrinos
Michael N. Mindrinos Stanford University
Serge R. Guiot
Serge R. Guiot University of Montreal
Ronen Hazan
Ronen Hazan Hebrew University of Jerusalem
Jerrold R. Turner
Jerrold R. Turner Brigham and Women's Hospital
Eugene B. Chang
Eugene B. Chang University of Chicago
Donald E. Woods
Donald E. Woods University of Calgary

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