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Chemistry

D-Index
56
Citations
10194
World Ranking
11739
National Ranking
380

Overview

Angelo Carotti is affiliated with the University of Bari Aldo Moro in Italy. Their research activities span the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Computer Science. Subfields of focus include Computational Theory and Mathematics, Molecular Biology, Pharmacology, Physiology, and Endocrinology, Diabetes and Metabolism.

The scientific contributions of Carotti involve multiple topics, including:

  • Computational Drug Discovery Methods
  • Cholinesterase and Neurodegenerative Diseases
  • Alzheimer's disease research and treatments
  • Hormonal Regulation and Hypertension
  • ATP Synthase and ATPases Research
  • Estrogen and related hormone effects
  • Synthesis and biological activity

Carotti has published research in several venues, notably:

  • European Journal of Medicinal Chemistry
  • ACS Medicinal Chemistry Letters
  • Methods in molecular biology

Recent publications include:

  • "Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease" (2023, European Journal of Medicinal Chemistry)
  • "17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer" (2021, ACS Medicinal Chemistry Letters)
  • "Informed Use of 3D-QSAR for the Rational Design of Coumarin Derivatives as Potent and Selective MAO B Inhibitors" (2022, Methods in molecular biology)

Frequent collaborators in Carotti's research include:

  • Marco Catto
  • Leonardo Pisani
  • Orazio Nicolotti
  • Michele Tonelli
  • Raimon Sabaté

Best Publications

  • Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

    Angela Stefanachi;Francesco Leonetti;Leonardo Pisani;Marco Catto

  • Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.

    Claudia Binda;Jin Wang;Leonardo Pisani;Carla Caccia

  • Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase

    Corinne Brühlmann;Frédéric Ooms;Pierre-Alain Carrupt;Bernard Testa

  • Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs.

    Carmela Gnerre;Marco Catto;Francesco Leonetti;Peter Weber

  • Role of the carbohydrate moieties in chiral recognition on teicoplanin-based LC stationary phases.

    Alain Berthod;Xianghong Chen;John P. Kullman;Daniel W. Armstrong

  • Applicability Domain for QSAR models: where theory meets reality

    Domenico Gadaleta;Giuseppe Felice Mangiatordi;Marco Catto;Angelo Carotti

  • Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening

    Laura Novaroli;Marianne Reist;Elisabeth Favre;Angelo Carotti

  • Novel 2-Phenylimidazo[1,2-a]pyridine Derivatives as Potent and Selective Ligands for Peripheral Benzodiazepine Receptors: Synthesis, Binding Affinity, and in Vivo Studies

    Giuseppe Trapani;Massimo Franco;Andrea Latrofa;Laura Ricciardi

  • Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors.

    Francesco Leonetti;Angelo Favia;Angela Rao;Rosaria Aliano

  • Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease

    Kevin St.P. McNaught;Pierre-Alain Carrupt;Cosimo Altomare;Saverio Cellamare

  • A convenient synthesis of nitriles from primary amides under mild conditions

    F Campagna;Angelo Carotti;G. Casini

  • Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.

    Leonardo Pisani;Giovanni Muncipinto;Teresa Fabiola Miscioscia;Orazio Nicolotti

  • Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies

    Angelo Carotti;Antonio Carrieri;Stefano Chimichi;Marco Boccalini

  • Three-dimensional model of the human aromatase enzyme and density functional parameterization of the iron-containing protoporphyrin IX for a molecular dynamics study of heme-cysteinato cytochromes.

    Angelo Danilo Favia;Andrea Cavalli;Matteo Masetti;Angelo Carotti

  • Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: Effects of lipophilicity and structure-activity relationships

    Cosimo Altomare;Saverio Cellamare;Luciana Summo;Marco Catto

  • 9,10-Anthraquinone hinders β-aggregation: How does a small molecule interfere with Aβ-peptide amyloid fibrillation?

    Marino Convertino;Riccardo Pellarin;Marco Catto;Angelo Carotti

  • Impact of Species-Dependent Differences on Screening, Design, and Development of MAO B Inhibitors

    Laura Novaroli;Antoine Daina;Elisabeth Favre;Juan Bravo

  • Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents

    Leonardo Pisani;Roberta Farina;Marco Catto;Rosa Maria Iacobazzi

  • Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.

    Marco Catto;Leonardo Pisani;Francesco Leonetti;Orazio Nicolotti

  • Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases

    Roberta Farina;Leonardo Pisani;Marco Catto;Orazio Nicolotti

  • The practice of medicinal chemistry

    C Altomare;Francesco Berardi;Angelo Carotti;G Casini

Frequent Co-Authors

Pierre-Alain Carrupt
Pierre-Alain Carrupt École Polytechnique Fédérale de Lausanne
Bernard Testa
Bernard Testa University of Lausanne
Rolf W. Hartmann
Rolf W. Hartmann Helmholtz Centre for Infection Research
Corwin Hansch
Corwin Hansch Pomona College
Peter Jenner
Peter Jenner King's College London
Francesco Gasparrini
Francesco Gasparrini Sapienza University of Rome
Giovanni Biggio
Giovanni Biggio University of Cagliari
Alba Chimirri
Alba Chimirri University of Messina
Ettore Novellino
Ettore Novellino University of Naples Federico II
Charles David Marsden
Charles David Marsden King's College London

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