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Fumio Sakane

Fumio Sakane

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
7719
World Ranking
17331
National Ranking
1249

Overview

Fumio Sakane is affiliated with Chiba University in Japan and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology with a specific focus on molecular biology and cell biology. Their research portfolio encompasses a variety of topics, including lipid metabolism and biosynthesis, sphingolipid metabolism and signaling, endoplasmic reticulum stress and disease, protein kinase regulation and GTPase signaling, cellular transport and secretion, metabolism related to diabetes and cancer, and lipid membrane structure and behavior.

The scientist's recent publications highlight their engagement with lipid signaling pathways and enzyme functions related to cellular metabolism. Notable papers include:

  • New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein (2020), International Journal of Molecular Sciences
  • The Roles of Diacylglycerol Kinase α in Cancer Cell Proliferation and Apoptosis (2021), Cancers

Although not the primary author, related significant works coauthored by frequent collaborators or within the same research domain include:

  • Sphingomyelin synthase-related protein generates diacylglycerol via the hydrolysis of glycerophospholipids in the absence of ceramide (2021), Journal of Biological Chemistry
  • 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain (2020), FEBS Letters
  • Diacylglycerol kinase δ and sphingomyelin synthase-related protein functionally interact via their sterile α motif domains (2020), Journal of Biological Chemistry

The frequent coauthors contributing to the scientist's body of work include Chiaki Murakami, Fumi Hoshino, Hiromichi Sakai, Daisuke Takahashi, and Qiang Lü, indicating collaborative research activities spanning molecular signaling and lipid enzymology.

Publishing regularly in key scientific journals, the scientist has contributed multiple articles to The FASEB Journal, Journal of Biological Chemistry, and FEBS Letters, along with works in Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, and Biochemical and Biophysical Research Communications.

Areas of study show a concentration on biochemical processes at the molecular level, including the regulation of lipid metabolic pathways and intracellular signaling mechanisms. Their research contributes to understanding complex biological functions related to cell proliferation, apoptosis, and cellular transport systems.

Best Publications

  • Diacylglycerol kinases: why so many of them?

    Fumio Sakane;Shin-ichi Imai;Masahiro Kai;Satoshi Yasuda

  • Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance

    Alexander V. Chibalin;Ying Leng;Elaine Vieira;Anna Krook

  • Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

    Fumio Sakane;Keiko Yamada;Hideo Kanoh;Chieko Yokoyama

  • Diacylglycerol kinase: a key modulator of signal transduction?

    Hideo Kanoh;Keiko Yamada;Fumio Sakane

  • Chaperone function of calreticulin when expressed in the endoplasmic reticulum as the membrane-anchored and soluble forms

    Ikuo Wada;Shin-ichi Imai;Masahiro Kai;Fumio Sakane

  • Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase

    Masahiro Kai;Ikuo Wada;Shin-ichi Imai;Fumio Sakane

  • Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl- inositol lipid signaling.

    Elena B. Rodriguez de Turco;Wen Tang;Matthew K. Topham;Fumio Sakane

  • Porcine 80-kDa diacylglycerol kinase is a calcium-binding and calcium/phospholipid-dependent enzyme and undergoes calcium-dependent translocation.

    F. Sakane;K. Yamada;S.-I. Imai;H. Kanoh

  • Selectivity of the diacylglycerol kinase inhibitor 3-[2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl]-2, 3-dihydro-2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes.

    Ying Jiang;Fumio Sakane;Hideo Kanoh;James P Walsh

  • Molecular Cloning of a Novel Diacylglycerol Kinase Isozyme with a Pleckstrin Homology Domain and a C-terminal Tail Similar to Those of the EPH Family of Protein-tyrosine Kinases

    Fumio Sakane;Shin-ichi Imai;Masahiro Kai;Ikuo Wada

  • Identification and cDNA Cloning of 35-kDa Phosphatidic Acid Phosphatase (Type 2) Bound to Plasma Membranes: POLYMERASE CHAIN REACTION AMPLIFICATION OF MOUSE H2O2-INDUCIBLE hic53 CLONE YIELDED THE cDNA ENCODING PHOSPHATIDIC ACID PHOSPHATASE *

    Masahiro Kai;Ikuo Wada;Shin-ichi Imai;Fumio Sakane

  • Diacylglycerol Kinases: Emerging Downstream Regulators in Cell Signaling Systems

    Hideo Kanoh;Keiko Yamada;Fumio Sakane

  • Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol.

    Fumio Sakane;Keiko Yamada;Hideo Kanoh

  • Diacylglycerol kinase δ regulates protein kinase C and epidermal growth factor receptor signaling

    Tracy Crotty;Jinjin Cai;Fumio Sakane;Akinobu Taketomi

  • Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells

    Masahiro Kai;Fumio Sakane;Shin-Ichi Imai;Ikuo Wada

  • Identification and Characterization of a Novel Human Type II Diacylglycerol Kinase, DGKκ

    Shin-ichi Imai;Masahiro Kai;Satoshi Yasuda;Hideo Kanoh

  • Alternative Splicing of the Human Diacylglycerol Kinase δ Gene Generates Two Isoforms Differing in Their Expression Patterns and in Regulatory Functions

    Fumio Sakane;Shin-ichi Imai;Keiko Yamada;Tomohiro Murakami

  • Gene cloning, sequence, expression and in situ localization of 80 kDa diacylglycerol kinase specific to oligodendrocyte of rat brain.

    Kaoru Goto;Masahiko Watanabe;Hisatake Kondo;Hiroo Yuasa

  • Identification and Characterization of Two Splice Variants of Human Diacylglycerol Kinase η

    Tomohiro Murakami;Fumio Sakane;Shin-ichi Imai;Kiyohiro Houkin

  • Molecules in focus: diacylglycerol kinase.

    F Sakane;H Kanoh

Frequent Co-Authors

Hideo Kanoh
Hideo Kanoh Sapporo Medical University
Ikuo Wada
Ikuo Wada Fukushima Medical University
Akinobu Taketomi
Akinobu Taketomi Hokkaido University
Yuji Suzuki
Yuji Suzuki University of Tokyo
Hisatake Kondo
Hisatake Kondo Tohoku University
Isabel Mérida
Isabel Mérida Spanish National Research Council
Masahiko Watanabe
Masahiko Watanabe Hokkaido University
Ushio Kikkawa
Ushio Kikkawa Kobe University
Takeshi Urano
Takeshi Urano Shimane University
Masato Hirata
Masato Hirata Fukuoka Dental College

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