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Biology and Biochemistry

D-Index
46
Citations
7283
World Ranking
18967
National Ranking
429

Overview

Isabel Mérida is affiliated with the Spanish National Research Council in Spain. Their research primarily spans the fields of immunology and microbiology, with additional contributions to medicine. Their work focuses on various subfields including immunology, cell biology, oncology, neurology, and infectious diseases.

Their research topics highlight key areas such as T-cell and B-cell immunology, immune cell function and interaction, cancer immunotherapy and biomarkers, SARS-CoV-2 and COVID-19 research, immune cells in cancer, CAR-T cell therapy research, and barrier structure and function studies.

Recent papers authored or coauthored by Isabel Mérida include:

  • Diacylglycerol kinase ζ promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse (2020, Science Signaling)
  • SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Promote a Proinflammatory Activation Profile on Human Dendritic Cells (2021, Cells)
  • Diacylglycerol kinase α inhibition cooperates with PD-1-targeted therapies to restore the T cell activation program (2021, Cancer Immunology Immunotherapy)
  • Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes (2020, Journal for ImmunoTherapy of Cancer)
  • Diacylglycerol kinases: A look into the future of immunotherapy (2023, Advances in Biological Regulation)

Frequently published venues for their work include:

  • Advances in Biological Regulation
  • Frontiers in Immunology
  • International Journal of Molecular Sciences
  • Journal of Leukocyte Biology
  • Science Signaling

Isabel Mérida regularly collaborates with several coauthors, among them:

  • Rosa Liébana
  • Antonia Ávila-Flores
  • Cristina Rodríguez-Rodríguez
  • Miguel Martin-Salgado
  • Ane Ochoa-Echeverría

Best Publications

  • Diacylglycerol, when simplicity becomes complex

    Silvia Carrasco;Isabel Mérida

  • Diacylglycerol kinases : at the hub of cell signalling

    Isabel Mérida;Antonia Ávila-Flores;Ernesto Merino

  • Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3‐kinase

    Concepción Jimenez;David R. Jones;Pablo Rodríguez‐Viciana;Ana Gonzalez‐García

  • Identification of Insulin-like Growth Factor-binding Protein-1 as a Potential Physiological Substrate for Human Stromelysin-3

    Santos Mañes;Emilia Mira;Maria del Mar Barbacid;Angel Ciprés

  • Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis.

    M Vicente-Manzanares;M Rey;D R Jones;D Sancho

  • Modulation of the Mammalian Target of Rapamycin Pathway by Diacylglycerol Kinase-produced Phosphatidic Acid *

    Antonia Ávila-Flores;Teresa Santos;Esther Rincón;Isabel Mérida

  • Role of diacylglycerol kinase α in the attenuation of receptor signaling

    Miguel Angel Sanjuán;David R. Jones;Manuel Izquierdo;Isabel Mérida

  • Diacylglycerol-dependent Binding Recruits PKCθ and RasGRP1 C1 Domains to Specific Subcellular Localizations in Living T Lymphocytes

    Silvia Carrasco;Isabel Merida

  • Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

    R Alonso;C Mazzeo;M C Rodriguez;M Marsh

  • Glucose transport and antilipolysis are differentially regulated by the polar head group of an insulin-sensitive glycophospholipid

    Kathleen L. Kelly;Jose M. Mato;Isabel Merida;Leonard Jarett

  • A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex

    Thomas Clairfeuille;Caroline Mas;Audrey S M Chan;Zhe Yang

  • Diacylglycerol Kinase α Regulates the Secretion of Lethal Exosomes Bearing Fas Ligand during Activation-induced Cell Death of T Lymphocytes

    Roberto Alonso;M. Carmen Rodríguez;Jose Pindado;Ernesto Merino

  • IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase.

    I Merida;E Diez;G N Gaulton

  • Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced α-Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation (∗)

    Ignacio Flores;Teresa Casaseca;Carlos Martinez-A;Hideo Kanoh

  • Essential function for the GTPase TC21 in homeostatic antigen receptor signaling.

    Pilar Delgado;Beatriz Cubelos;Enrique Calleja;Nuria Martínez-Martín

  • Shaping up the membrane: diacylglycerol coordinates spatial orientation of signaling

    María Almena;Isabel Mérida

  • Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension.

    Julián Aragonés;David R. Jones;Silvia Martı́n;Miguel Angel San Juan

  • T Cell Activation In Vivo Targets Diacylglycerol Kinase α to the Membrane: A Novel Mechanism for Ras Attenuation

    Miguel A. Sanjuán;Bérengère Pradet-Balade;David R. Jones;Carlos Martínez-A

  • Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway.

    Inés Fernández-Ulibarri;Montserrat Vilella;Francisco Lázaro-Diéguez;Elisabet Sarri

  • Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway

    Ana González-García;Isabel Mérida;Carlos Martinez-A;Ana C. Carrera

Frequent Co-Authors

Carlos Martínez-A
Carlos Martínez-A Spanish National Research Council
José M. Mato
José M. Mato CIC bioGUNE
Juan Pablo Albar
Juan Pablo Albar Spanish National Research Council
Ana C. Carrera
Ana C. Carrera Spanish National Research Council
Naoaki Saito
Naoaki Saito Kobe University
Brett M. Collins
Brett M. Collins University of Queensland
Mayte Villalba
Mayte Villalba Complutense University of Madrid
Gary A. Koretzky
Gary A. Koretzky Cornell University
Mario Mellado
Mario Mellado Spanish National Research Council
Fumio Sakane
Fumio Sakane Chiba University

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