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Biology and Biochemistry

D-Index
58
Citations
11591
World Ranking
13221
National Ranking
919

Overview

Ikuo Wada is affiliated with Fukushima Medical University in Japan and has a research profile focused primarily on medicine and biochemistry, genetics, and molecular biology. Their scholarly contributions span several subfields, including molecular biology, cell biology, pulmonary and respiratory medicine, genetics, and public health, environmental, and occupational health.

The scientist's work addresses multiple main topics, such as gastrointestinal tumor research and treatment, sperm and testicular function, cancer immunotherapy and biomarkers, gastric cancer management and outcomes, reproductive biology and fertility, cellular transport and secretion, and endoplasmic reticulum stress and disease.

Wada's recent papers reflect an interdisciplinary approach combining molecular and cellular biology with medical research. Notable publications include:

  • Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion (2021, eLife)
  • Unveiling a novel function of CD9 in surface compartmentalization of oocytes (2020, Development)
  • Visualization of Procollagen IV Reveals ER-to-Golgi Transport by ERGIC-independent Carriers (2020, Cell Structure and Function)
  • Integrative immunogenomic analysis of gastric cancer dictates novel immunological classification and the functional status of tumor-infiltrating cells (2020, Clinical & Translational Immunology)
  • Evaluation of the Cytotoxicity of Various Hand Disinfectants and Ozonated Water to Human Keratinocytes in a Cultured Epidermal Model (2020, Advances in Skin & Wound Care)

Frequent coauthors collaborating with Wada include Naokazu Inoue, Yasuyoshi Sato, Yukari Kobayashi, Koji Nagaoka, and Yasuyuki Seto. This collaboration network suggests active engagement in multidisciplinary research efforts.

Scientific publications by Wada are often found in journals such as Cell Structure and Function, Molecular Reproduction and Development, Proceedings for Annual Meeting of The Japanese Pharmacological Society, eLife, and Development. These venues suggest an emphasis on molecular and cellular techniques relevant to reproduction, development, and pharmacology.

The breadth of Wada's work across 41 publications in medicine and 25 in biochemistry, genetics, and molecular biology highlights a sustained focus on understanding biological processes at the molecular level and their implications in disease and reproductive health. Their research contributes to fields essential for cancer therapy development, fertility studies, and cellular transport mechanisms.

Best Publications

  • Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

    Seiichi Oyadomari;Kiyoshi Takeda;Masaki Takiguchi;Tomomi Gotoh

  • A novel ER α-mannosidase-like protein accelerates ER-associated degradation

    Nobuko Hosokawa;Ikuo Wada;Kiyotaka Hasegawa;Tetuya Yorihuzi

  • SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane.

    I. Wada;D. Rindress;P.H. Cameron;W.J. Ou

  • EDEM As an Acceptor of Terminally Misfolded Glycoproteins Released from Calnexin

    Yukako Oda;Nobuko Hosokawa;Ikuo Wada;Kazuhiro Nagata

  • EDEM3, a Soluble EDEM Homolog, Enhances Glycoprotein Endoplasmic Reticulum-associated Degradation and Mannose Trimming

    Kazuyoshi Hirao;Yuko Natsuka;Taku Tamura;Ikuo Wada

  • Human M-Ficolin Is a Secretory Protein That Activates the Lectin Complement Pathway

    Yu Liu;Yuichi Endo;Daisuke Iwaki;Munehiro Nakata

  • The Putative Chaperone Calmegin is Required for Sperm Fertility

    M. Ikawa;I. Wada;K. Kominami;D. Watanabe

  • Enhancement of Endoplasmic Reticulum (ER) Degradation of Misfolded Null Hong Kong α1-Antitrypsin by Human ER Mannosidase I

    Nobuko Hosokawa;Linda O. Tremblay;Zhipeng You;Annette Herscovics

  • Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood–brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways

    Tsutomu Ishizaki;Hideki Chiba;Takashi Kojima;Masato Fujibe

  • Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.

    Nobuko Hosokawa;Ikuo Wada;Koji Nagasawa;Tatsuya Moriyama

  • Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva

    Toru Fukuda;Masakazu Kohda;Kazuhiro Kanomata;Junya Nojima

  • Oculocutaneous albinism types 1 and 3 are ER retention diseases: mutation of tyrosinase or Tyrp1 can affect the processing of both mutant and wild-type proteins

    Kazutomo Toyofuku;Ikuo Wada;Julio C. Valencia;Tsuneto Kushimoto

  • Chaperone function of calreticulin when expressed in the endoplasmic reticulum as the membrane-anchored and soluble forms

    Ikuo Wada;Shin-ichi Imai;Masahiro Kai;Fumio Sakane

  • Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase

    Masahiro Kai;Ikuo Wada;Shin-ichi Imai;Fumio Sakane

  • Calmegin Is Required for Fertilin α/β Heterodimerization and Sperm Fertility

    Masahito Ikawa;Tomoko Nakanishi;Shuichi Yamada;Ikuo Wada

  • Calsperin is a testis specific chaperone required for sperm fertility

    Masahito Ikawa;Keizo Tokuhiro;Ryo Yamaguchi;Adam M. Benham;Adam M. Benham

  • Molecular Cloning of a Novel Diacylglycerol Kinase Isozyme with a Pleckstrin Homology Domain and a C-terminal Tail Similar to Those of the EPH Family of Protein-tyrosine Kinases

    Fumio Sakane;Shin-ichi Imai;Masahiro Kai;Ikuo Wada

  • EDEM1 accelerates the trimming of α1,2-linked mannose on the C branch of N-glycans

    Nobuko Hosokawa;Linda O Tremblay;Barry Sleno;Yukiko Kamiya;Yukiko Kamiya

  • Identification and cDNA Cloning of 35-kDa Phosphatidic Acid Phosphatase (Type 2) Bound to Plasma Membranes: POLYMERASE CHAIN REACTION AMPLIFICATION OF MOUSE H2O2-INDUCIBLE hic53 CLONE YIELDED THE cDNA ENCODING PHOSPHATIDIC ACID PHOSPHATASE *

    Masahiro Kai;Ikuo Wada;Shin-ichi Imai;Fumio Sakane

  • A tissue-engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose-derived stem cells.

    Ken Kobayashi;Teruhisa Suzuki;Yukio Nomoto;Yasuhiro Tada

Frequent Co-Authors

Hideo Kanoh
Hideo Kanoh Sapporo Medical University
Fumio Sakane
Fumio Sakane Chiba University
Kazuhiro Nagata
Kazuhiro Nagata Kyoto Sangyo University
Masahito Ikawa
Masahito Ikawa Osaka University
John J. M. Bergeron
John J. M. Bergeron McGill University
Masaru Okabe
Masaru Okabe Osaka University
Annette Herscovics
Annette Herscovics McGill University
Katsuya Okawa
Katsuya Okawa Kyowa Kirin (Japan)
Koichi Kato
Koichi Kato National Institutes of Natural Sciences
Yoshio Kuroki
Yoshio Kuroki Sapporo Medical University

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