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Ushio Kikkawa

Ushio Kikkawa

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
35914
World Ranking
3621
National Ranking
227

Overview

Ushio Kikkawa is affiliated with Kobe University in Japan and has contributed extensively to the field of biochemistry, genetics, and molecular biology, with a particular focus on molecular biology and cancer research.

The scientist's research encompasses several main topics including:

  • Cancer, Hypoxia, and Metabolism
  • Glioma Diagnosis and Treatment
  • Cancer, Lipids, and Metabolism
  • Fungal and yeast genetics research
  • Cancer-related molecular mechanisms research
  • MicroRNA in disease regulation
  • Circular RNAs in diseases

Key subfields of study for Kikkawa include:

  • Molecular Biology
  • Cancer Research
  • Genetics
  • Neurology
  • Physiology

Ushio Kikkawa's recent papers illustrate a focus on glioblastoma and related metabolic and molecular pathways:

  • "Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation," 2022, Journal of Biomedical Science
  • "HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells," 2022, Journal of Experimental & Clinical Cancer Research
  • "Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells," 2021, Cell Death and Disease
  • "LY6D-induced macropinocytosis as a survival mechanism of senescent cells," 2020, Journal of Biological Chemistry
  • "The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy," 2020, Journal of Cell Science

Frequent coauthors in Kikkawa's work include:

  • Wen-Bin Yang
  • Kwang-Yu Chang
  • Tsung-I Hsu
  • Akio Nakashima
  • Pin-Yuan Chen

Publications have appeared regularly in venues such as:

  • Biomolecules
  • Journal of Biomedical Science
  • Journal of Experimental & Clinical Cancer Research
  • Cell Death and Disease
  • Journal of Biological Chemistry

Best Publications

  • Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters

    M Castagna;Y Takai;K Kaibuchi;K Sano

  • Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

    A. Kishimoto;Y. Takai;T. Mori;U. Kikkawa

  • Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

    U Kikkawa;Y Takai;R Minakuchi;S Inohara

  • Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

    U Kikkawa;Y Takai;Y Tanaka;R Miyake

  • The Protein Kinase C Family: Heterogeneity and its Implications

    Ushio Kikkawa;Akira Kishimoto;Yasutomi Nishizuka

  • Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

    Yoshimi Takai;Akira Kishimoto;Ushio Kikkawa;Terutoshi Mori

  • Activation of protein kinase C by tyrosine phosphorylation in response to H2O2

    Hiroaki Konishi;Motonari Tanaka;Yukitoshi Takemura;Hidenori Matsuzaki

  • The Role of Protein Kinase C in Transmembrane Signalling

    Ushio Kikkawa;Yasutomi Nishizuka

  • Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

    Yoshitaka Ono;Tomoko Fujii;Kouji Ogita;Ushio Kikkawa

  • Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence

    Yoshitaka Ono;Tomoko Fujii;Koichi Igarashi;Takayoshi Kuno

  • Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.

    Tadahiro Kitamura;Yukari Kitamura;Shoji Kuroda;Yasuhisa Hino

  • Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.

    Anning Lin;Jeffrey A Frost;Tiliang Deng;Tod Smeal

  • Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport

    Tadahiro Kitamura;Wataru Ogawa;Hiroshi Sakaue;Yasuhisa Hino

  • Expression and properties of two types of protein kinase C: alternative splicing from a single gene.

    Yoshitaka Ono;Ushio Kikkawa;Kouji Ogita;Tomoko Fujii

  • Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies

    Tatsuya Watanabe;Yoshitaka Ono;Yoshio Taniyama;Kumiko Hazama

  • Distribution of protein kinase C-like immunoreactive neurons in rat brain.

    N Saito;U Kikkawa;Y Nishizuka;C Tanaka

  • Calcium-activated, phospholipid-dependent protein kinase (protein kinase C) from rat brain.

    Ushio Kikkawa;Ryoji Minakuchi;Yoshimi Takai;Yasutomi Nishizuka

  • Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27.

    Hiroaki Konishi;Hidenori Matsuzaki;Motonari Tanaka;Yukitoshi Takemura

  • Phosphorylation sites of protein kinase C δ in H2O2-treated cells and its activation by tyrosine kinase in vitro

    Hiroaki Konishi;Emiko Yamauchi;Hisaaki Taniguchi;Toshiyoshi Yamamoto

  • The Proline-rich Akt Substrate of 40 kDa (PRAS40) Is a Physiological Substrate of Mammalian Target of Rapamycin Complex 1

    Noriko Oshiro;Rinako Takahashi;Ken-ichi Yoshino;Keiko Tanimura

Frequent Co-Authors

Yasutomi Nishizuka
Yasutomi Nishizuka Kobe University
Naoaki Saito
Naoaki Saito Kobe University
Chikako Tanaka
Chikako Tanaka Kobe University
Kazuyoshi Yonezawa
Kazuyoshi Yonezawa Kobe University
Yoshimi Takai
Yoshimi Takai Kobe University
Kozo Kaibuchi
Kozo Kaibuchi Nagoya University
Shun'ichi Kuroda
Shun'ichi Kuroda Osaka University
Joseph Avruch
Joseph Avruch Harvard University
Robert V. Farese
Robert V. Farese Harvard University
Hiroyuki Nakanishi
Hiroyuki Nakanishi Kumamoto University

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