2026 Marcelo G. Kazanietz: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	73	5911	5452	2795	2506	228	19946

Overview

Marcelo G. Kazanietz is affiliated with the University of Pennsylvania in the United States and has contributed extensively to research in biochemistry, genetics, and molecular biology, with a focus also encompassing medicine. Their work spans key subfields including molecular biology, cell biology, oncology, genetics, and pulmonary and respiratory medicine.

The scientist's research addresses several main topics, notably:

Protein kinase regulation and GTPase signaling
Cellular mechanics and interactions
Hippo pathway signaling and YAP/TAZ
PI3K/AKT/mTOR signaling in cancer
Microtubule and mitosis dynamics
Melanoma and MAPK pathways
Cancer-related molecular pathways

Marcelo G. Kazanietz has coauthored research frequently with the following colleagues:

Mariana Cooke
Martin J. Baker
Suli Zhang
Martín C. Abba
Rafael García-Mata

Their work has appeared in multiple publication venues, with recurring contributions to:

Journal of Biological Chemistry
bioRxiv (Cold Spring Harbor Laboratory)
The FASEB Journal
Frontiers in Cell and Developmental Biology
Cancer Research Communications

Recent notable papers reflect a diverse set of research interests, including:

"Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition," 2021, Proceedings of the National Academy of Sciences
"Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity," 2022, Science Signaling
"FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma," 2021, Cell Reports
"Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology," 2022, Brain
"Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease," 2020, American Journal of Physiology-Cell Physiology

Best Publications

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

G Martiny-Baron;M G Kazanietz;H Mischak;P M Blumberg

1877
Citations
Protein kinase C and other diacylglycerol effectors in cancer

Erin M. Griner;Marcelo G. Kazanietz

1173
Citations
Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

Gongyi Zhang;Marcelo G Kazanietz;Peter M Blumberg;James H Hurley

857
Citations
New insights into the regulation of protein kinase C and novel phorbol ester receptors

Dorit Ron;Marcelo G. Kazanietz

787
Citations
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

H Mischak;J A Goodnight;W Kolch;G Martiny-Baron

708
Citations
Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

K Ozawa;Z Szallasi;M G Kazanietz;P M Blumberg

535
Citations
Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes.

M. G. Kazanietz;L. B. Areces;Afshin Bahador;H. Mischak

398
Citations
C1 domains exposed: from diacylglycerol binding to protein-protein interactions.

Francheska Colón-González;Marcelo G Kazanietz

362
Citations
Arachidonic Acid in Platelet Microparticles Up-regulates Cyclooxygenase-2-dependent Prostaglandin Formation via a Protein Kinase C/Mitogen-activated Protein Kinase-dependent Pathway

Orla P. Barry;Marcelo G. Kazanietz;Domenico Praticò;Garret A. FitzGerald

339
Citations
Protein Kinase C Promotes Apoptosis in LNCaP Prostate Cancer Cells through Activation of p38 MAPK and Inhibition of the Akt Survival Pathway

Yuichi Tanaka;M.Veronica Gavrielides;Yasuhiro Mitsuuchi;Teruhiko Fujii

332
Citations
Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.

H Mischak;J H Pierce;J Goodnight;M G Kazanietz

312
Citations
Protein kinase C and cancer: what we know and what we do not

Rachana Garg;Lorena G. Benedetti;Mahlet B. Abera;HongBin Wang

309
Citations
Divergence and complexities in DAG signaling: looking beyond PKC

ChengFeng Yang;Marcelo G Kazanietz

300
Citations
Novel “Nonkinase” Phorbol Ester Receptors: The C1 Domain Connection

Marcelo G. Kazanietz

277
Citations
CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond

Marcelo G. Kazanietz;Michael Durando;Mariana Cooke

263
Citations
Involvement of Protein Kinase C δ (PKCδ) in Phorbol Ester-induced Apoptosis in LNCaP Prostate Cancer Cells LACK OF PROTEOLYTIC CLEAVAGE OF PKCδ

Teruhiko Fujii;Marı́a Laura Garcı́a-Bermejo;Juan Lucas Bernabó;Jorge Caamaño

260
Citations
Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways.

Pilar Chinchilla;Liqing Xiao;Marcelo G. Kazanietz;Natalia A. Riobo

256
Citations
Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters.

Marcelo G. Kazanietz

248
Citations
Rac signaling in breast cancer: a tale of GEFs and GAPs.

Eva Wertheimer;Alvaro Gutierrez-Uzquiza;Cinthia Rosemblit;Cynthia Lopez-Haber

236
Citations
Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer

Maria Soledad Sosa;Cynthia Lopez-Haber;Chengfeng Yang;Hong Bin Wang

228
Citations