Kazuyoshi Yonezawa

Overview

Best Publications

• Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

  Kenta Hara;Yoshiko Maruki;Xiaomeng Long;Ken ichi Yoshino

  2224
  Citations

• Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

  Kenta Hara;Kazuyoshi Yonezawa;Qing-Ping Weng;Mark T. Kozlowski

  1670
  Citations

• Rheb Binds and Regulates the mTOR Kinase

  Xiaomeng Long;Yenshou Lin;Sara Ortiz-Vega;Kazuyoshi Yonezawa

  1207
  Citations

• The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif

  Hiroki Nojima;Hiroki Nojima;Chiharu Tokunaga;Satoshi Eguchi;Noriko Oshiro

  852
  Citations

• mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells.

  Mirei Murakami;Tomoko Ichisaka;Tomoko Ichisaka;Mitsuyo Maeda;Noriko Oshiro;Noriko Oshiro

  750
  Citations

• Regulation of eIF-4E BP1 Phosphorylation by mTOR

  Kenta Hara;Kazuyoshi Yonezawa;Mark T. Kozlowski;Tadanori Sugimoto

  721
  Citations

• PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

  R Dhand;I Hiles;G Panayotou;S Roche

  607
  Citations

• Tor directly controls the Atg1 kinase complex to regulate autophagy.

  Yoshiaki Kamada;Ken-ichi Yoshino;Chika Kondo;Tomoko Kawamata

  562
  Citations

• Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

  Stefan Wennström;Phillip Hawkins;Frank Cooke;Kenta Hara

  560
  Citations

• 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

  K Hara;K Yonezawa;H Sakaue;A Ando

  546
  Citations

• Brain-Derived Neurotrophic Factor Induces Mammalian Target of Rapamycin-Dependent Local Activation of Translation Machinery and Protein Synthesis in Neuronal Dendrites

  Nobuyuki Takei;Naoko Inamura;Mihoko Kawamura;Hisaaki Namba

  539
  Citations

• Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin.

  J F Clarke;P W Young;K Yonezawa;M Kasuga

  492
  Citations

• Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro

  Shuji Isotani;Kenta Hara;Chiharu Tokunaga;Hitomi Inoue

  474
  Citations

• A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

  Naoki Kimura;Chiharu Tokunaga;Sushila Dalal;Christine Richardson

  459
  Citations

• PI 3-kinase: structural and functional analysis of intersubunit interactions.

  Ritu Dhand;K. Hara;I. Hiles;B. Bax

  441
  Citations

• Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling

  K Kotani;K Yonezawa;K Hara;H Ueda

  441
  Citations

• Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.

  Noriko Oshiro;Ken-ichi Yoshino;Sujuti Hidayat;Chiharu Tokunaga

  415
  Citations

• The Proline-rich Akt Substrate of 40 kDa (PRAS40) Is a Physiological Substrate of Mammalian Target of Rapamycin Complex 1

  Noriko Oshiro;Rinako Takahashi;Ken-ichi Yoshino;Keiko Tanimura

  343
  Citations

• Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

  J. Avruch;K. Hara;Yen-Shou Lin;M. Liu

  309
  Citations

• The Proline-rich Akt Substrate of 40 kDa (PRAS40) Is a Physiological Substrate of Mammalian Target of

  Noriko Oshiro;Rinako Takahashi;Ken-ichi Yoshino;Keiko Tanimura

  0
  Citations