World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
106
Citations
33832
World Ranking
1166
National Ranking
692

Medicine

D-Index
106
Citations
33796
World Ranking
6614
National Ranking
3508

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Leonard S. Jefferson is affiliated with Pennsylvania State University in the United States and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work has a particular focus on Molecular Biology and Cell Biology, with additional involvement in Pulmonary and Respiratory Medicine, Cellular and Molecular Neuroscience, and Biomedical Engineering.

The scientist's research interests revolve around several specialized topics, including:

  • PI3K/AKT/mTOR signaling in cancer
  • Muscle Physiology and Disorders
  • Protein Kinase Regulation and GTPase Signaling
  • Muscle metabolism and nutrition
  • Genetic Neurodegenerative Diseases
  • Muscle activation and electromyography studies
  • Fibroblast Growth Factor Research

Leonard S. Jefferson has contributed to multiple research publications, with recent notable papers that provide insights into protein synthesis regulation, signaling pathways, and metabolic processes. Significant papers include:

  • "A time course for markers of protein synthesis and degradation with hindlimb unloading and the accompanying anabolic resistance to refeeding," 2020, Journal of Applied Physiology
  • "Loss of 4E-BPs prevents the hindlimb immobilization-induced decrease in protein synthesis in skeletal muscle," 2022, Journal of Applied Physiology
  • "Glucagon-dependent suppression of mTORC1 is associated with upregulation of hepatic FGF21 mRNA translation," 2020, American Journal of Physiology-Endocrinology and Metabolism
  • "Convergence of signaling pathways in mediating actions of leucine and IGF-1 on mTORC1 in L6 myoblasts," 2022, American Journal of Physiology-Cell Physiology
  • "Glucose-Induced Activation of mTORC1 is Associated with Hexokinase2 Binding to Sestrins in HEK293T Cells," 2022, Journal of Nutrition

The primary venues for Leonard S. Jefferson's work include:

  • Journal of Applied Physiology
  • American Journal of Physiology-Endocrinology and Metabolism
  • American Journal of Physiology-Cell Physiology
  • Journal of Nutrition
  • Frontiers in Endocrinology

Collaborative research is a notable aspect of this scientist's career. Frequent co-authors include:

  • Scot R. Kimball
  • Paul A. Roberson
  • Jaclyn E. Welles
  • Gregory N. Kincheloe
  • Michael D. Dennis

Leonard S. Jefferson was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2015.

Best Publications

  • AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.

    Douglas R. Bolster;Stephen J. Crozier;Scot R. Kimball;Leonard S. Jefferson

  • Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway

    Joshua C. Anthony;Fumiaki Yoshizawa;Tracy Gautsch Anthony;Thomas C. Vary

  • Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.

    David A. Antonetti;Alistair J. Barber;Sarah K. Bronson;Willard M. Freeman

  • Signaling Pathways and Molecular Mechanisms through which Branched-Chain Amino Acids Mediate Translational Control of Protein Synthesis

    Scot R. Kimball;Leonard S. Jefferson

  • Signaling Pathways Involved in Translational Control of Protein Synthesis in Skeletal Muscle by Leucine

    Joshua C. Anthony;Tracy G. Anthony;Scot R. Kimball;Leonard S. Jefferson

  • Orally Administered Leucine Stimulates Protein Synthesis in Skeletal Muscle of Postabsorptive Rats in Association with Increased eIF4F Formation

    Joshua C. Anthony;Tracy Gautsch Anthony;Scot R. Kimball;Thomas C. Vary

  • The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice

    Peichuan Zhang;Peichuan Zhang;Barbara C. McGrath;Jamie Reinert;De Anne S. Olsen

  • Oral Leucine Administration Stimulates Protein Synthesis in Rat Skeletal Muscle

    Stephen J. Crozier;Scot R. Kimball;Sans W. Emmert;Joshua C. Anthony

  • Regulation of protein synthesis in heart muscle. I. Effect of amino acid levels on protein synthesis.

    H.E. Morgan;D.C.N. Earl;A. Broadus;E.B. Wolpert

  • Role of Adenosine 3',5'-Monophosphate in the Effects of Insulin and Anti-insulin Serum on Liver Metabolism

    L. S. Jefferson;J. H. Exton;R. W. Butcher;Earl W. Sutherland

  • Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.

    Scot R. Kimball;Lisa M. Shantz;Rick L. Horetsky;Leonard S. Jefferson

  • Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1

    Hongmei Wang;Neil Kubica;Leif W. Ellisen;Leonard S. Jefferson

  • Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise

    Scot R. Kimball;Peter A. Farrell;Leonard S. Jefferson

  • Influence of amino acid availability on protein turnover in perfused skeletal muscle.

    Jeanne B. Li;Leonard S. Jefferson

  • Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.

    Scot R. Kimball;Rick L. Horetsky;David Ron;Leonard S. Jefferson

  • 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle.

    O. Jameel Shah;Joshua C. Anthony;Scot R. Kimball;Leonard S. Jefferson

  • Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle

    Douglas R. Bolster;Neil Kubica;Stephen J. Crozier;David L. Williamson

  • New functions for amino acids: effects on gene transcription and translation

    Scot R Kimball;Leonard S Jefferson

  • Role of Insulin in the Regulation of Protein Synthesis

    Leonard S. Jefferson

  • Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction during development and in response to glucocorticoids and insulin.

    Nabil A. Elshourbagy;Mark S. Boguski;Warren S. L. Liao;Leonard S. Jefferson

Frequent Co-Authors

Scot R. Kimball
Scot R. Kimball Pennsylvania State University
Charles H. Lang
Charles H. Lang Pennsylvania State University
Anthony E. Pegg
Anthony E. Pegg Pennsylvania State University
Allan Lipton
Allan Lipton Penn State Milton S. Hershey Medical Center
Douglas R. Cavener
Douglas R. Cavener Pennsylvania State University
Patrice Fort
Patrice Fort University of Michigan–Ann Arbor
Robert L. Matts
Robert L. Matts Oklahoma State University
Susan M. Hutson
Susan M. Hutson Virginia Tech
John C. Lawrence
John C. Lawrence University of Virginia
Yuguang Shi
Yuguang Shi The University of Texas Health Science Center at San Antonio

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