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Biology and Biochemistry

D-Index
55
Citations
6565
World Ranking
15316
National Ranking
6385

Overview

Robert L. Matts is affiliated with Oklahoma State University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a strong emphasis on molecular biology as a subfield.

The main topics covered in their work include:

  • Heat shock proteins research
  • ATP Synthase and ATPases Research
  • Thermodynamics and calorimetric analyses
  • Computational Drug Discovery Methods
  • Toxin Mechanisms and Immunotoxins
  • Enzyme Structure and Function
  • CO2 Reduction Techniques and Catalysts

Robert L. Matts has published research in several scientific venues, with multiple papers appearing in Angewandte Chemie and related journals. Frequent publication outlets include:

  • Angewandte Chemie
  • Angewandte Chemie International Edition
  • ACS Medicinal Chemistry Letters
  • European Journal of Medicinal Chemistry
  • Acta Crystallographica Section D Structural Biology

Recent papers by Robert L. Matts include:

  • Selective Inhibition of the Hsp90α Isoform, 2021, Angewandte Chemie International Edition
  • Structure-Activity Relationship Study of Tertiary Alcohol Hsp90α-Selective Inhibitors with Novel Binding Mode, 2022, ACS Medicinal Chemistry Letters
  • Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes, 2023, European Journal of Medicinal Chemistry
  • Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target, 2022, Acta Crystallographica Section D Structural Biology
  • Structural basis of the key residue W320 responsible for Hsp90 conformational change, 2022, Journal of Biomolecular Structure and Dynamics

Their research involves collaboration with several co-authors who have frequently contributed alongside them. Regular collaborators include:

  • Shuxia Peng
  • Junpeng Deng
  • Maurie Balch
  • Taylor Merfeld
  • Brian S. J. Blagg

Best Publications

  • Collagen Coating Promotes Biocompatibility of Semiconductor Nanoparticles in Stratified LBL Films

    Vladimir A. Sinani;Dmitry S. Koktysh;Bo Geon Yun;Robert L. Matts

  • Single-walled carbon nanotube polyelectrolyte multilayers and freestanding films as a biocompatible platform for neuroprosthetic implants

    Muhammed K. Gheith;Vladimir A. Sinani;James P. Wicksted;Robert L. Matts

  • ATP-dependent Chaperoning Activity of Reticulocyte Lysate*

    Robert J. Schumacher;Robin Hurst;William P. Sullivan;Nancy J. McMahon

  • Biomaterials by Design: Layer‐By‐Layer Assembled Ion‐Selective and Biocompatible Films of TiO2 Nanoshells for Neurochemical Monitoring

    D. S. Koktysh;X. Liang;B. G. Yun;I. Pastoriza-Santos

  • Effect of phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 on the function of reversing factor in the initiation of protein synthesis.

    Robert L. Matts;Daniel H. Levin;Irving M. London

  • Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.

    Wanping Xu;Mehdi Mollapour;Chrisostomos Prodromou;Suiquan Wang

  • Gambogic acid, a natural product inhibitor of Hsp90.

    Jason Davenport;Jacob R. Manjarrez;Laura B. Peterson;Brian Krumm

  • Phosphorylation of Serine 13 Is Required for the Proper Function of the Hsp90 Co-chaperone, Cdc37

    Jieya Shao;Thomas Prince;Steven D. Hartson;Robert L. Matts

  • Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions

    Bo Geon Yun;Wenjun Huang;Natalie Leach;Steven D. Hartson

  • Two Heme-binding Domains of Heme-regulated Eukaryotic Initiation Factor-2α Kinase N TERMINUS AND KINASE INSERTION

    Maryam Rafie-Kolpin;Peter J. Chefalo;Zareena Hussain;Joyce Hahn

  • Association of Hsp90 with Cellular Src-Family Kinases in a Cell-Free System Correlates with Altered Kinase Structure and Function

    Steven D. Hartson;Robert L. Matts

  • Hsp90 Is Obligatory for the Heme-regulated eIF-2α Kinase to Acquire and Maintain an Activable Conformation

    Sheri Uma;Steven D. Hartson;Jane Jane Chen;Robert L. Matts

  • Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae

    Janet L. Bushman;Agatha I. Asuru;Robert L. Matts;Alan G. Hinnebusch

  • High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.

    Lakshmi Galam;M. Kyle Hadden;Zeqiang Ma;Qi Zhuang Ye

  • KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells.

    Shary N. Shelton;Mary E. Shawgo;Shawna B. Matthews;Yuanming Lu

  • Elucidation of the Hsp90 C-terminal inhibitor binding site.

    Robert L. Matts;Anshuman Dixit;Laura B. Peterson;Liang Sun

  • p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules.

    Steven D. Hartson;Angela D. Irwin;Angela D. Irwin;Jieya Shao;Bradley T. Scroggins

  • 12 Regulation of Protein Synthesis

    Irving M. London;Daniel H. Levin;Robert L. Matts;N. Shaun B Thomas

  • Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

    Jeffery D Eskew;Takrima Sadikot;Pedro Morales;Alicia Duren

  • Evidence for the Association of the Heme-regulated eIF-2α Kinase with the 90-kDa Heat Shock Protein in Rabbit Reticulocyte Lysate in Situ

    R L Matts;R Hurst

Frequent Co-Authors

Brian S. J. Blagg
Brian S. J. Blagg University of Notre Dame
Nicholas A. Kotov
Nicholas A. Kotov University of Michigan–Ann Arbor
Leonard S. Jefferson
Leonard S. Jefferson Pennsylvania State University
Scot R. Kimball
Scot R. Kimball Pennsylvania State University
Isao Morishima
Isao Morishima Kyoto University
Satoshi Takahashi
Satoshi Takahashi Tohoku University
Koichiro Ishimori
Koichiro Ishimori Hokkaido University
Guolong Zhang
Guolong Zhang Oklahoma State University
Jamie H. D. Cate
Jamie H. D. Cate University of California, Berkeley
Isabel Pastoriza-Santos
Isabel Pastoriza-Santos Universidade de Vigo

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