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D-Index & Metrics

Molecular Biology

D-Index
121
Citations
47324
World Ranking
251
National Ranking
146

Research.com Recognitions

  • 2015 - Member of the National Academy of Sciences
  • 2009 - Fellow of the American Academy of Arts and Sciences
  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Alan G. Hinnebusch is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a notable concentration in molecular biology. They have contributed extensively to topics related to RNA research and splicing, RNA and protein synthesis mechanisms, and RNA modifications and cancer.

Their recent scholarly output includes papers published in a variety of scientific journals. Some of the prominent recent publications are:

  • "Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes," 2020, Molecular Cell
  • "Translational regulation by uORFs and start codon selection stringency," 2023, Genes & Development
  • "eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide," 2020, RNA
  • "Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo," 2020, eLife
  • "Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs," 2021, eLife

Alan G. Hinnebusch has frequently collaborated with several researchers, including:

  • Swati Gaikwad
  • Hongen Zhang
  • Anil Kumar Vijjamarri
  • Hongfang Qiu
  • Chisom Onu

Their work is often published in the following venues, with several papers appearing in each:

  • eLife
  • Nucleic Acids Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Journal of Biological Chemistry

Within their broader field, their subfields of study also include cell biology, endocrinology, plant science, and genetics, though these have fewer publications compared to molecular biology. The topics they cover extend beyond RNA mechanisms to include fungal and yeast genetics research, genomics and chromatin dynamics, CRISPR and genetic engineering, and viral infectious diseases and gene expression in insects.

Alan G. Hinnebusch has been recognized by several professional bodies. They were made a Member of the National Academy of Sciences in 2015, elected as a Fellow of the American Academy of Arts and Sciences in 2009, and named a Fellow of the American Association for the Advancement of Science (AAAS) in 2008.

Best Publications

  • Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

    Nahum Sonenberg;Alan G. Hinnebusch

  • Translational regulation of GCN4 and the general amino acid control of yeast.

    Alan G Hinnebusch

  • Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast

    Krishnamurthy Natarajan;Michael R. Meyer;Belinda M. Jackson;David Slade

  • The Scanning Mechanism of Eukaryotic Translation Initiation

    Alan G Hinnebusch

  • Translational control by 5′-untranslated regions of eukaryotic mRNAs

    Alan G. Hinnebusch;Ivaylo P. Ivanov;Nahum Sonenberg

  • Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

    Thomas E. Dever;Lan Feng;Ronald C. Wek;A.Mark Cigan

  • Translational Regulation of Yeast GCN4 A WINDOW ON FACTORS THAT CONTROL INITIATOR-tRNA BINDING TO THE RIBOSOME

    Alan G. Hinnebusch

  • Multiple upstream AUG codons mediate translational control of GCN4

    Peter P. Mueller;Alan G. Hinnebusch

  • The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

    Alan G. Hinnebusch;Jon R. Lorsch

  • Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain.

    Jinsheng Dong;Hongfang Qiu;Minerva Garcia-Barrio;James T. Anderson

  • Evidence for translational regulation of the activator of general amino acid control in yeast.

    Alan G. Hinnebusch

  • Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae.

    Sujatha Kadaba;Anna Krueger;Tamyra Trice;Annette M. Krecic

  • Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3.

    Marcel Martin;Marcel Martin;Lars Maßhöfer;Petra Temming;Sven Rahmann

  • eIF3: a versatile scaffold for translation initiation complexes.

    Alan G. Hinnebusch

  • Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes

    Alan G. Hinnebusch

  • Gcn4p, a Master Regulator of Gene Expression, Is Controlled at Multiple Levels by Diverse Signals of Starvation and Stress

    Alan G. Hinnebusch;Krishnamurthy Natarajan

  • Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation

    Thanuja Krishnamoorthy;Graham D. Pavitt;Fan Zhang;Thomas E. Dever

  • Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron.

    Andrew Dancis;Dragos G. Roman;Gregory J. Anderson;Alan G. Hinnebusch

  • A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNAMet is an important translation initiation intermediate in vivo

    Katsura Asano;Jason Clayton;Anath Shalev;Alan G. Hinnebusch

  • Translational Regulation of GCN4 and the General Amino Acid Control

    Alan G. Hinnebusch

Frequent Co-Authors

Jon R. Lorsch
Jon R. Lorsch National Institutes of Health
Leoš Shivaya Valášek
Leoš Shivaya Valášek Czech Academy of Sciences
Thomas E. Dever
Thomas E. Dever National Institutes of Health
Graham D. Pavitt
Graham D. Pavitt University of Manchester
James M. Anderson
James M. Anderson National Institutes of Health
Venki Ramakrishnan
Venki Ramakrishnan MRC Laboratory of Molecular Biology
Thomas Preiss
Thomas Preiss Australian National University
Nicholas T. Ingolia
Nicholas T. Ingolia University of California, Berkeley
John W. B. Hershey
John W. B. Hershey University of California, Davis
Gerhard Wagner
Gerhard Wagner Harvard University

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