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D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
27724
World Ranking
5816
National Ranking
2751

Overview

Ronald C. Wek is affiliated with Indiana University in the United States and specializes in the field of Biochemistry, Genetics and Molecular Biology. Their research predominantly covers Molecular Biology, Cell Biology, Epidemiology, Parasitology, and Physiology, with a strong focus on topics related to Endoplasmic Reticulum Stress and Disease, RNA regulation and disease, and Toxoplasma gondii research studies.

The scientist has contributed to numerous publication venues, primarily in the Journal of Biological Chemistry, with a total of 26 publications. Other frequent venues include Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), mBio, and The FASEB Journal.

Key areas of research explored by Ronald C. Wek include RNA Research and Splicing, RNA modifications and cancer, RNA and protein synthesis mechanisms, as well as Adipose Tissue and Metabolism. These topics reflect a broad interest in the molecular mechanisms regulating cellular stress responses and protein synthesis.

Frequent co-authors in their work include Tracy G. Anthony, Kirk A. Staschke, Karin Musier-Forsyth, Lila M. Gierasch, and F. Peter Guengerich, indicating collaborative research efforts within these scientific circles.

Among recent published papers are:

  • Activation of Gcn2 by small molecules designed to be inhibitors, 2023, Journal of Biological Chemistry
  • Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response, 2023, Antioxidants and Redox Signaling
  • GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis, 2022, eLife
  • Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy, 2021, Journal of Nutrition
  • Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress, 2021, Nucleic Acids Research

Best Publications

  • Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

    Heather P Harding;Isabel Novoa;Yuhong Zhang;Huiqing Zeng

  • Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

    Krishna M. Vattem;Ronald C. Wek

  • Coping with stress: eIF2 kinases and translational control

    R.C. Wek;H.-Y. Jiang;T.G. Anthony

  • Identification and characterization of pancreatic eukaryotic initiation factor 2 α-subunit kinase, PEK, involved in translational control

    Yuguang Shi;Krishna M. Vattem;Ruchira Sood;Jie An

  • Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

    Thomas E. Dever;Lan Feng;Ronald C. Wek;A.Mark Cigan

  • The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.

    Sheree A. Wek;Shuhao Zhu;Ronald C. Wek

  • Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.

    Hao Yuan Jiang;Sheree A. Wek;Barbara C. McGrath;Dan Lu

  • Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

    Thomas D. Baird;Ronald C. Wek

  • Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation

    Lakshmi Reddy Palam;Thomas D. Baird;Ronald C. Wek

  • The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice

    Peichuan Zhang;Peichuan Zhang;Barbara C. McGrath;Jamie Reinert;De Anne S. Olsen

  • Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses

    Hao Yuan Jiang;Sheree A. Wek;Barbara C. McGrath;Donalyn Scheuner

  • Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress.

    Ronald C. Wek

  • The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

    Brian F. Teske;Sheree A. Wek;Piyawan Bunpo;Judy K. Cundiff

  • Phosphorylation of the α-subunit of the eukaryotic initiation factor-2 (eIF2α) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition

    Hao Yuan Jiang;Ronald C. Wek

  • Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex

    Shuzhen Hao;James W. Sharp;Catherine M. Ross-Inta;Brent J. McDaniel

  • Translational control and the unfolded protein response.

    Ronald C. Wek;Douglas R. Cavener

  • A Mammalian Homologue of GCN2 Protein Kinase Important for Translational Control by Phosphorylation of Eukaryotic Initiation Factor-2α

    Ruchira Sood;Amy C. Porter;De Anne Olsen;Douglas R. Cavener

  • Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress.

    Kun Ma;Krishna M. Vattem;Ronald C. Wek

  • Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response

    Sara K. Young;Ronald C. Wek

  • Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions.

    Donghui Zhou;L. Reddy Palam;Li Jiang;Jana Narasimhan

Frequent Co-Authors

William J. Sullivan
William J. Sullivan Indiana University
Douglas R. Cavener
Douglas R. Cavener Pennsylvania State University
David B. Burr
David B. Burr Indiana University
Robert A. Harris
Robert A. Harris Indiana University
Scot R. Kimball
Scot R. Kimball Pennsylvania State University
Christopher M. Adams
Christopher M. Adams University of Iowa
G. Wesley Hatfield
G. Wesley Hatfield University of California, Irvine
Maria Hatzoglou
Maria Hatzoglou Case Western Reserve University
Tao Pan
Tao Pan Jinan University
Matthew S. Sachs
Matthew S. Sachs Texas A&M University

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