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Biology and Biochemistry

D-Index
89
Citations
22918
World Ranking
2622
National Ranking
1366

Research.com Recognitions

  • 1982 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1972 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1965 - Fellow of Alfred P. Sloan Foundation

Overview

Robert A. Harris is affiliated with Indiana University in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research portfolio consists of 29 publications in Biochemistry, Genetics and Molecular Biology and 15 publications in Medicine.

Their work emphasizes subfields such as molecular biology, cancer research, physiology, surgery, and clinical biochemistry. Key research topics include metabolism, diabetes, cancer, mitochondrial function and pathology, cancer hypoxia and metabolism, pancreatic function related to diabetes, metabolism and genetic disorders, biochemical acid research studies, and alcohol consumption and health effects.

Notable recent papers authored or co-authored by Robert A. Harris include:

  • The Role of Pyruvate Metabolism in Mitochondrial Quality Control and Inflammation (2023, Molecules and Cells)
  • Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion (2023, Kidney International)
  • Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases (2020, Journal of Diabetes Investigation)
  • Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease (2023, Nature Communications)
  • Noncanonical PDK4 action alters mitochondrial dynamics to affect the cellular respiratory status (2022, Proceedings of the National Academy of Sciences)

Frequent co-authors with whom Robert A. Harris has collaborated include Themis Thoudam, In-Kyu Lee, Jae-Han Jeon, Min-Ji Kim, and Dipanjan Chanda. Their research has been repeatedly published in venues such as Experimental & Molecular Medicine, Molecules and Cells, Kidney International, Journal of Diabetes Investigation, and Nature Communications.

Throughout their career, Robert A. Harris has received several recognitions including being named a Fellow of the John Simon Guggenheim Memorial Foundation in 1982, a Fellow of the American Association for the Advancement of Science (AAAS) in 1972, and a Fellow of the Alfred P. Sloan Foundation in 1965.

Best Publications

  • Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise

    Yoshiharu Shimomura;Taro Murakami;Naoya Nakai;Masaru Nagasaki

  • Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

    Julián Aragonés;Martin Schneider;Martin Schneider;Martin Schneider;Katie Van Geyte;Katie Van Geyte;Peter Fraisl;Peter Fraisl

  • Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

    Thomas McFate;Ahmed Mohyeldin;Huasheng Lu;Jay Thakar

  • A molecular model of human branched-chain amino acid metabolism.

    A Suryawan;J W Hawes;R A Harris;Y Shimomura

  • Regulation of the activity of the pyruvate dehydrogenase complex.

    Robert A. Harris;Melissa M. Bowker-Kinley;Boli Huang;Pengfei Wu

  • Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes.

    Pengfei Wu;K. Inskeep;M. M. Bowker-Kinley;K. M. Popov

  • Regulation of Pyruvate Dehydrogenase Kinase Expression by Peroxisome Proliferator–Activated Receptor-α Ligands, Glucocorticoids, and Insulin

    Boli Huang;Pengfei Wu;Melissa M. Bowker-Kinley;Robert A. Harris

  • Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy

    Gaia Novarino;Paul El-Fishawy;Hulya Kayserili;Nagwa A. Meguid

  • Mitochondrial matrix phosphoproteome : Effect of extra mitochondrial calcium

    Rachel K. Hopper;Stefanie Carroll;Angel M. Aponte;D. Thor Johnson

  • Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation.

    Boli Huang;Ramadevi Gudi;Pengfei Wu;Robert A. Harris

  • Cloning and Characterization of PDK4 on 7q21.3 Encoding a Fourth Pyruvate Dehydrogenase Kinase Isoenzyme in Human

    Joie Rowles;Stephen W. Scherer;Tina Xi;Martin Majer

  • Starvation Increases the Amount of Pyruvate Dehydrogenase Kinase in Several Mammalian Tissues

    Pengfei Wu;Paul V. Blair;Juichi Sato;Jerzy Jaskiewicz

  • Adaptive Increase in Pyruvate Dehydrogenase Kinase 4 during Starvation Is Mediated by Peroxisome Proliferator-Activated Receptor α

    Pengfei Wu;Jeffrey M. Peters;Robert A. Harris

  • Branched-chain alpha-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases.

    Kirill M. Popov;Yu Zhao;Yoshiharu Shimomura;Martha J. Kuntz

  • Conformational basis of energy transformations in membrane systems: III. Configurational changes in the mitochondrial inner membrane induced by changes in functional states

    David E. Green;Junpei Asai;Robert A. Harris;John T. Penniston

  • Tissue heterogeneity of the mammalian mitochondrial proteome

    D. Thor Johnson;Robert A. Harris;Stephanie French;Paul V. Blair

  • Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.

    M J Holness;A Kraus;R A Harris;M C Sugden

  • Protein Kinase B-α Inhibits Human Pyruvate Dehydrogenase Kinase-4 Gene Induction by Dexamethasone Through Inactivation of FOXO Transcription Factors

    Hye Sook Kwon;Boli Huang;Terry G. Unterman;Robert A. Harris

  • Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet

    Sandra J. Peters;Robert A. Harris;Pengfei Wu;Tanya L. Pehleman

  • Regulation of branched-chain α-ketoacid dehydrogenase kinase

    Ralph Paxton;Robert A. Harris

Frequent Co-Authors

Yoshiharu Shimomura
Yoshiharu Shimomura Nagoya University
David W. Crabb
David W. Crabb Indiana University
Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
Kyoungho Suk
Kyoungho Suk Kyungpook National University
Daehee Hwang
Daehee Hwang Seoul National University
Rafael A. Fissore
Rafael A. Fissore University of Massachusetts Amherst
Roger J. Colbran
Roger J. Colbran Vanderbilt University
Richard E. Lee
Richard E. Lee St. Jude Children's Research Hospital
Cynthia J. Jameson
Cynthia J. Jameson University of Illinois at Chicago

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