David T. Chuang

Overview

Best Publications

• Catabolic defect of branched-chain amino acids promotes heart failure

  Haipeng Sun;Haipeng Sun;Kristine C. Olson;Chen Gao;Domenick A. Prosdocimo

  445
  Citations

• Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol

  Masato Kato;Jun Li;Jacinta L. Chuang;David T. Chuang

  293
  Citations

• The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

  Phillip J. White;Phillip J. White;Robert W. McGarrah;Robert W. McGarrah;Paul A. Grimsrud;Shih Chia Tso

  275
  Citations

• Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.

  Meiyi Zhou;Jing Shao;Cheng Yang Wu;Le Shu

  240
  Citations

• Seeing GroEL at 6 Å Resolution by Single Particle Electron Cryomicroscopy

  Steven J. Ludtke;Dong Hua Chen;Jiu Li Song;David T. Chuang

  240
  Citations

• De Novo Backbone Trace of GroEL from Single Particle Electron Cryomicroscopy.

  Steven J. Ludtke;Matthew L. Baker;Dong Hua Chen;Jiu Li Song

  210
  Citations

• Crystal structure of human branched-chain α-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease

  Arnthor Ævarsson;Jacinta L. Chuang;R. Max Wynn;Stewart Turley

  198
  Citations

• Chaperonins groEL and groES promote assembly of heterotetramers (alpha 2 beta 2) of mammalian mitochondrial branched-chain alpha-keto acid decarboxylase in Escherichia coli.

  Richard M Wynn;James R. Davie;Rody P Cox;David T Chuang

  162
  Citations

• Lessons from Genetic Disorders of Branched-Chain Amino Acid Metabolism

  David T. Chuang;Jacinta L. Chuang;R. Max Wynn

  158
  Citations

• Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope

  Patrick S. C. Leung;David T. Chuang;R. Max Wynn;Sanghoon Cha

  158
  Citations

• Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.

  Masato Kato;R. Max Wynn;Jacinta L. Chuang;Shih Chia Tso

  158
  Citations

• A 11.5 Å single particle reconstruction of GroEL using EMAN

  Steven J. Ludtke;Joanita Jakana;Jiu Li Song;David T. Chuang

  153
  Citations

• Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations.

  Chad A. Brautigam;Jacinta L. Chuang;Diana R. Tomchick;Mischa Machius

  149
  Citations

• Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex

  Masato Kato;Jacinta L. Chuang;Shih Chia Tso;R. Max Wynn

  146
  Citations

• Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex.

  Chad A. Brautigam;R. Max Wynn;Jacinta L. Chuang;Mischa Machius

  130
  Citations

• PHENYLBUTYRATE THERAPY FOR MAPLE SYRUP URINE DISEASE

  Nicola Brunetti-Pierri;Brendan Lanpher;Ayelet Erez;Elitsa A. Ananieva

  119
  Citations

• A Novel Branched-chain Amino Acid Metabolon PROTEIN-PROTEIN INTERACTIONS IN A SUPRAMOLECULAR COMPLEX

  Mohammad Mainul Islam;Reidar Wallin;R. Max Wynn;Myra Conway

  117
  Citations

• Branched-chain Amino Acid Metabolon INTERACTION OF GLUTAMATE DEHYDROGENASE WITH THE MITOCHONDRIAL BRANCHED-CHAIN AMINOTRANSFERASE (BCATm)

  Mohammad Mainul Islam;Manisha Nautiyal;R. Max Wynn;James A. Mobley

  115
  Citations

• Structure of rat BCKD kinase: Nucleotide-induced domain communication in a mitochondrial protein kinase

  Mischa Machius;Jacinta L. Chuang;Richard M Wynn;Diana R Tomchick

  111
  Citations

• Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity

  R. Max Wynn;Masato Kato;Jacinta L. Chuang;Shih Chia Tso

  104
  Citations