World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
51
Citations
8142
World Ranking
14104
National Ranking
3648

Biology and Biochemistry

D-Index
51
Citations
8134
World Ranking
17296
National Ranking
7112

Overview

Thomas E. Roche is affiliated with Kansas State University in the United States. Their research spans multiple areas within engineering, with a focus on ocean engineering, mechanical engineering, computer networks and communications, urban studies, and geography, planning, and development.

The scientist's research work covers several main topics, including oil and gas production techniques, reservoir engineering and simulation methods, hydraulic fracturing and reservoir analysis, cultural insights and digital impacts, social sciences and governance, as well as historical geography and geographical thought.

Recent publications include:

  • Identification of Downhole Emulsion in a Light Oil Development and Demulsifier Injection for Increasing Production, 2023, International Petroleum Technology Conference
  • Open Scholarly Publishing and Knowledge Mobilization: Combining Two Initiatives to Achieve Social Impact, 2021, Scholarly and Research Communication
  • The geography of higher education of Newfoundland and Labrador, Canada, 2023, OECD SME and entrepreneurship papers
  • How Emerald Publishing Has Embedded the Sustainable Development Goals Publisher Compact Into Its Business Strategy, 2021, Science Editor

Frequent coauthors who have collaborated with Roche include Huu Huy Vu, Manisa Rangponsumrit, Ngoc Dong Hoang, Duy Hung Nguyen, and Hai Nam Tran.

Their work has appeared in a variety of publication venues, notably:

  • International Petroleum Technology Conference
  • Scholarly and Research Communication
  • OECD SME and entrepreneurship papers
  • Science Editor

This body of research makes significant contributions across several intersecting disciplines, highlighting multiple engineering and social science dimensions. The diverse focus areas suggest a cross-disciplinary approach involving both technical and digital-cultural considerations in contemporary research contexts.

Best Publications

  • Molecular biology and biochemistry of pyruvate dehydrogenase complexes.

    Mulchand S. Patel;Thomas E. Roche

  • Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart

    Stephen J. Yeaman;Eldridge T. Hutcheson;Thomas E. Roche;Flora H. Pettit

  • Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms.

    Thomas E. Roche;Jason C. Baker;Xiaohua Yan;Yasuaki Hiromasa

  • Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

    T. E. Roche;Yasuaki Hiromasa

  • Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis.

    Shinji Shimoda;Shinji Shimoda;Judith A Van de Water;Aftab Ansari;Minoru Nakamura

  • Keto acid dehydrogenase complexes. XVII. Kinetic and regulatory properties of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase from bovine kidney and heart

    Ferdinand Hucho;Douglas D. Randall;Thomas E. Roche;Michael W. Burgett

  • Function of calcium ions in pyruvate dehydrogenase phosphatase activity.

    Flora H. Pettit;Thomas E. Roche;Lester J. Reed

  • Spectrophotometric assay of the flavin-containing monooxygenase and changes in its activity in female mouse liver with nutritional and diurnal conditions.

    Aparna Dixit;Thomas E. Roche

  • Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis.

    J Van de Water;A A Ansari;C D Surh;R Coppel

  • Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis.

    J. Van De Water;A. Ansari;T. Prindiville;R. L. Coppel

  • Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex.

    J M Jilka;M Rahmatullah;M Kazemi;T E Roche

  • Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross-reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex.

    Charles D. Surh;Thomas E. Roche;Dean J. Danner;Aftab Ansari

  • Marked Differences between Two Isoforms of Human Pyruvate Dehydrogenase Kinase

    Jason C. Baker;Xiaohua Yan;Tao Peng;Shane Kasten

  • Alpha-Keto Acid Dehydrogenase Complexes

    Mulchand S. Patel;Thomas E. Roche;Robert A. Harris

  • Purification of porcine liver pyruvate dehydrogenase complex and characterization of its catalytic and regulatory properties

    Thomas E. Roche;Richard L. Cate

  • Regulatory Roles of the N-Terminal Domain Based on Crystal Structures of Human Pyruvate Dehydrogenase Kinase 2 Containing Physiological and Synthetic Ligands†,‡

    Thorsten R. Knoechel;Alec D. Tucker;Colin M. Robinson;Chris Phillips

  • Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.

    Yasuaki Hiromasa;Tetsuro Fujisawa;Yoichi Aso;Thomas E. Roche

  • Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme.

    D R Fregeau;T E Roche;P A Davis;R Coppel

  • Mechanism of action of isocitrate lyase from Pseudomonas indigofera.

    Bruce A. McFadden;Judith O. Williams;Thomas E. Roche

  • Lipoyl Domain-based Mechanism for the Integrated Feedback Control of the Pyruvate Dehydrogenase Complex by Enhancement of Pyruvate Dehydrogenase Kinase Activity (∗)

    Sundari Ravindran;Gary A. Radke;John R. Guest;Thomas E. Roche

  • Function of the nonidentical subunits of mammalian pyruvate dehydrogenase.

    Thomas E. Roche;Lester J. Reed

  • Mechanism of pyruvate inhibition of kidney pyruvate dehydrogenasea kinase and synergistic inhibition by pyruvate and ADP.

    Unknown

Frequent Co-Authors

Lester J. Reed
Lester J. Reed The University of Texas at Austin
Mulchand S. Patel
Mulchand S. Patel University at Buffalo, State University of New York
Ross L. Coppel
Ross L. Coppel Monash University
Aftab A. Ansari
Aftab A. Ansari University of California, Davis
M. Eric Gershwin
M. Eric Gershwin University of California, Davis
Z. Hong Zhou
Z. Hong Zhou University of California, Los Angeles
Ferdinand Hucho
Ferdinand Hucho Freie Universität Berlin
Patrick S.C. Leung
Patrick S.C. Leung University of California, Davis
Karl J. Kramer
Karl J. Kramer Kansas State University
Robert A. Grassucci
Robert A. Grassucci Columbia University

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