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Immunology

D-Index
46
Citations
15232
World Ranking
4567
National Ranking
2058

Overview

Rimas J. Orentas is affiliated with the University of Washington in the United States and has a research portfolio focused primarily on the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work encompasses a range of subfields including Oncology, Molecular Biology, Immunology, Genetics, and Physiology.

The main research topics Orentas has contributed to include:

  • CAR-T cell therapy research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Virus-based gene therapy research
  • Immune Cell Function and Interaction
  • Biomedical Ethics and Regulation
  • Biosimilars and Bioanalytical Methods
  • Nanowire Synthesis and Applications

A selection of recent papers featuring Orentas includes:

  • Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial (2020, Nature Medicine)
  • Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis (2021, Nature Medicine)
  • Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety (2022, Cancer Discovery)
  • Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice (2020, Gastroenterology)
  • Trispecific CD19-CD20-CD22-targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models (2021, Science Translational Medicine)

Orentas frequently collaborates with several researchers, including:

  • Boro Dropulić
  • Michael C. Jensen
  • Dina Schneider
  • Ashley Wilson
  • Rebecca Gardner

Their work is regularly published in a set of scientific venues such as:

  • Cancer Research
  • Blood
  • Regular and Young Investigator Award Abstracts
  • Frontiers in Immunology
  • Neuro-Oncology

Best Publications

  • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

    Daniel W Lee;James N Kochenderfer;Maryalice Stetler-Stevenson;Yongzhi K Cui

  • 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

    Adrienne H Long;Waleed M Haso;Jack F Shern;Kelsey M Wanhainen

  • CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy.

    Terry J Fry;Nirali N Shah;Rimas J Orentas;Maryalice Stetler-Stevenson

  • Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia

    Waleed Haso;Daniel W. Lee;Nirali N. Shah;Maryalice Stetler-Stevenson

  • CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors.

    Robbie G. Majzner;Johanna L. Theruvath;Anandani Nellan;Sabine Heitzeneder

  • Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial

    Nirav N. Shah;Bryon D. Johnson;Dina Schneider;Fenlu Zhu

  • Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase

    Alec J. Walker;Robbie G. Majzner;Ling Zhang;Kelsey Wanhainen

  • Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation.

    James E. K. Hildreth;Rimas J. Orentas

  • CD19 CAR T cell product and disease attributes predict leukemia remission durability

    Olivia C. Finney;Hannah Brakke;Stephanie Rawlings-Rhea;Roxana Hicks

  • Reduction of MDSCs with All-trans Retinoic Acid Improves CAR Therapy Efficacy for Sarcomas.

    Adrienne H. Long;Steven L. Highfill;Yongzhi Cui;Jillian P. Smith

  • Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis

    Nicholas A. Vitanza;Nicholas A. Vitanza;Adam J. Johnson;Adam J. Johnson;Ashley L. Wilson;Ashley L. Wilson;Christopher Brown;Christopher Brown

  • A tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines.

    Dina Schneider;Ying Xiong;Darong Wu;Volker Nӧlle

  • Association of host cell surface adhesion receptors and other membrane proteins with HIV and SIV

    Rimas J. Orentas;James E. K. Hildreth

  • Towards a commercial process for the manufacture of genetically modified T cells for therapy

    A D Kaiser;M Assenmacher;B Schröder;M Meyer

  • Induction of CD4+ human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine

    Rimas J. Orentas;James E K Hildreth;Eugene Obah;Michael J Polydefkis

  • Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer

    Hua Zhang;Irena Maric;Michael J. DiPrima;Javed Khan

  • Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model.

    Kim Anthony-Gonda;Ariola Bardhi;Alex Ray;Nina Flerin

  • The Future Is Now: Chimeric Antigen Receptors as New Targeted Therapies for Childhood Cancer

    Daniel W. Lee;David M. Barrett;Crystal Mackall;Rimas Orentas

  • Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice

    Dan Li;Dan Li;Nan Li;Yi-Fan Zhang;Haiying Fu;Haiying Fu

  • Identification of Cell Surface Proteins as Potential Immunotherapy Targets in 12 Pediatric Cancers

    Rimas J. Orentas;James J. Yang;Xinyu Wen;Jun S. Wei

  • Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein.

    Haiying Qin;Monica Cho;Waleed Haso;Ling Zhang

Frequent Co-Authors

Crystal L. Mackall
Crystal L. Mackall Stanford University
Bryon D. Johnson
Bryon D. Johnson Medical College of Wisconsin
Terry J. Fry
Terry J. Fry University of Colorado Denver
Dimiter S. Dimitrov
Dimiter S. Dimitrov University of Pittsburgh
Javed Khan
Javed Khan National Institutes of Health
Michael C. Jensen
Michael C. Jensen Seattle Children's Hospital
Ira Pastan
Ira Pastan Center for Cancer Research
Poul H. Sorensen
Poul H. Sorensen University of British Columbia
David M. Barrett
David M. Barrett Children's Hospital of Philadelphia
Els Verhoeyen
Els Verhoeyen Inserm : Institut national de la santé et de la recherche médicale

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