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Molecular Biology

D-Index
89
Citations
26071
World Ranking
761
National Ranking
24

Overview

Poul H. Sorensen is affiliated with the University of British Columbia in Canada. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a secondary focus on medicine. Within these broader disciplines, Sorensen's work covers subfields including molecular biology, oncology, immunology, cancer research, and genetics.

The scientist has contributed to a range of main research topics, notably:

  • CAR-T cell therapy research
  • Neuroblastoma research and treatments
  • Glioma diagnosis and treatment
  • Epigenetics and DNA methylation
  • Cancer, hypoxia, and metabolism
  • Immune cell function and interaction
  • RNA modifications and cancer

Among their frequent collaborators are:

  • Alberto Delaidelli
  • Gian Luca Negri
  • Mads Daugaard
  • John M. Maris
  • Michael M. Lizardo

Sorensen has published extensively in several scientific journals. The venues with the highest number of publications include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Clinical Cancer Research
  • Nature Medicine

Among recent published papers are:

  • "Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors," 2020, Nature Medicine
  • "Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma," 2020, Nature Medicine
  • "Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication," 2022, Nature Medicine
  • "GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity," 2021, Cancer Cell
  • "Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma," 2020, Cell

This body of work reflects integration of molecular and cellular approaches to cancer research with a focus on immunotherapy strategies such as CAR-T cell design and delivery, as well as exploration of metabolic and epigenetic mechanisms underlying tumors.

Best Publications

  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes

    Paul A. Northcott;Paul A. Northcott;David J.H. Shih;John Peacock;Livia Garzia

  • Lin28 promotes transformation and is associated with advanced human malignancies

    Srinivas R Viswanathan;John T Powers;William Einhorn;Yujin Hoshida

  • CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors.

    Robbie G. Majzner;Johanna L. Theruvath;Anandani Nellan;Sabine Heitzeneder

  • The der(17)t(x;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25

    Marc Ladanyi;Man Yee Lui;Cristina R Antonescu;Amber Krause-Boehm

  • Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers

    Alireza Heravi-Moussavi;Michael S Anglesio;S-W Grace Cheng;Janine Senz

  • The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA

    Philipp Kapranov;Georges St Laurent;Georges St Laurent;Tal Raz;Fatih Ozsolak

  • Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein.

    Ki-Baik Hahm;Keuna Cho;Cecile Lee;Young-Hyuck Im

  • Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

    Amal M. El-Naggar;Chansey J. Veinotte;Hongwei Cheng;Thomas G.P. Grunewald

  • YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1.

    Syam Prakash Somasekharan;Syam Prakash Somasekharan;Amal El-Naggar;Amal El-Naggar;Gabriel Leprivier;Hongwei Cheng

  • E-Cadherin Cell-Cell Adhesion in Ewing Tumor Cells Mediates Suppression of Anoikis through Activation of the ErbB4 Tyrosine Kinase

    Hyung-Gyoo Kang;Jasmine M. Jenabi;Jingsong Zhang;Nino Keshelava

  • Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

    Jonathan K. M. Lim;Alberto Delaidelli;Sean W. Minaker;Hai-Feng Zhang

  • Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

    Johanna Theruvath;Elena Sotillo;Christopher W. Mount;Claus Moritz Graef

  • Reverse transcriptase PCR amplification of EWS/FLI-1 fusion transcripts as a diagnostic test for peripheral primitive neuroectodermal tumors of childhood

    Poul H.B. Sorensen;Xian Fang Liu;Olivier Delattre;Jon M. Rowland

  • ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages.

    Chris L. Lannon;Poul H.B. Sorensen

  • LEDGF (p75) promotes DNA-end resection and homologous recombination

    Mads Daugaard;Annika Baude;Kasper Fugger;Lou Klitgaard Povlsen

  • EWS-FLI1 and EWS-ERG Gene Fusions Are Associated With Similar Clinical Phenotypes in Ewing's Sarcoma

    Jill P. Ginsberg;Enrique de Alava;Marc Ladanyi;Leonard H. Wexler

  • Proteasome-mediated cleavage of the Y-box-binding protein 1 is linked to DNA-damage stress response

    Alexey V Sorokin;Anastasia A Selyutina;Maxim A Skabkin;Sergey G Guryanov

  • Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.

    Tony L. Ng;Maureen J. O'Sullivan;Catherine J. Pallen;Malcolm Hayes

  • The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers

    Liyong Zhang;Liyong Zhang;Michael S Anglesio;Maureen O'Sullivan;Fan Zhang

  • Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas.

    Jane Bayani;Maria Zielenska;Ajay Pandita;Khaldoun Al-Romaih

Frequent Co-Authors

Timothy J. Triche
Timothy J. Triche Van Andel Institute
Gregg B. Morin
Gregg B. Morin University of British Columbia
Michael D. Taylor
Michael D. Taylor University of Toronto
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Olivier Delattre
Olivier Delattre PSL University
Martin E. Gleave
Martin E. Gleave University of British Columbia
John M. Maris
John M. Maris Children's Hospital of Philadelphia
Josef M. Penninger
Josef M. Penninger University of British Columbia
C. Patrick Reynolds
C. Patrick Reynolds Texas Tech University Health Sciences Center
Jonathan D. Buckley
Jonathan D. Buckley University of South Australia

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