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Gerald Krystal

Gerald Krystal

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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
17898
World Ranking
5115
National Ranking
185

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Gerald Krystal is affiliated with the BC Cancer Agency in Canada and has conducted extensive research in the fields of Medicine, Biochemistry, Genetics, and Molecular Biology. Their work spans a variety of subfields including Molecular Biology, Physiology, Cancer Research, Immunology, and Oncology. The scientist's research has been disseminated through multiple publications, reflecting significant engagement with topics related to diet, metabolism, immune responses, and cancer biology.

Their recent research outputs encompass various topics such as Diet and Metabolism Studies, Diet, Metabolism, and Disease, Cancer, Hypoxia, and Metabolism, Immune Cell Function and Interaction, Adipokines, Inflammation, and Metabolic Diseases, Metabolism, Diabetes, and Cancer, as well as Sphingolipid Metabolism and Signaling.

  • The effect of smoking on chronic inflammation, immune function and blood cell composition (2020, Scientific Reports)
  • CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development (2021, OncoImmunology)
  • Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer (2020, Cancers)
  • Exploratory examination of inflammation state, immune response and blood cell composition in a human obese cohort to identify potential markers predicting cancer risk (2020, PLoS ONE)
  • Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-inflammatory Effects through SHIP1/STAT3 Complexes (2020, iScience)

Frequent collaborators include Ingrid Elisia, Michelle Yeung, Sara Kowalski, Vivian Lam, and Michael Y. Li. These coauthors reflect a network of interdisciplinary research partnerships supporting investigations in immune function, cancer, and metabolic disease mechanisms.

  • Current Developments in Nutrition
  • Frontiers in Nutrition
  • Scientific Reports
  • PLoS ONE
  • Cancers

Gerald Krystal's publication record shows a focus on nutrition and cancer intersection as evident in the frequent contribution to journals specializing in nutrition and cancer research. The integration of immunology and metabolic signaling pathways also marks their scientific output.

Best Publications

  • The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

    J. E. Damen;Ling Liu;P. Rosten;R. K. Humphries

  • Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

    Cheryl D. Helgason;Jacqueline E. Damen;Patty Rosten;Rewa Grewal

  • Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival.

    Janet Kalesnikoff;Michael Huber;Vivian Lam;Jacqueline E Damen

  • Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.

    Taolin Yi;A. L.-F. Mui;G. Krystal;J. N. Ihle

  • The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation

    Michael Huber;Cheryl D. Helgason;Jacqueline E. Damen;Ling Liu

  • LPS-induced upregulation of SHIP is essential for endotoxin tolerance

    Laura M. Sly;Michael J. Rauh;Janet Kalesnikoff;Christine H. Song

  • Multiple pathways involved in the biosynthesis of anandamide

    Jie Liu;Lei Wang;Judith Harvey-White;Bill X. Huang

  • Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

    J E Damen;H Wakao;A Miyajima;J Krosl

  • SHIP represses the generation of alternatively activated macrophages.

    Michael J. Rauh;Victor Ho;Carla Pereira;Anita Sham

  • Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases

    Eric Le Dréan;Frédéric Vély;Lucia Olcese;Anna Cambiaggi

  • Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

    R. L. Cutler;Ling Liu;J. E. Damen;G. Krystal

  • SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts.

    Sunao Takeshita;Noriyuki Namba;Noriyuki Namba;Jenny J Zhao;Yebin Jiang

  • A simple microassay for erythropoietin based on 3H-thymidine incorporation into spleen cells from phenylhydrazine treated mice.

    Krystal G

  • Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

    Jacqueline E. Damen;Ling Liu;Robert L. Cutler;Gerald Krystal

  • Phosphatidylinositol (3,4,5)P3 Is Essential but Not Sufficient for Protein Kinase B (PKB) Activation; Phosphatidylinositol (3,4)P2 Is Required for PKB Phosphorylation at Ser-473: STUDIES USING CELLS FROM SH2-CONTAINING INOSITOL-5-PHOSPHATASE KNOCKOUT MICE *

    Michael P. Scheid;Michael Huber;Jacqueline E. Damen;Michael Hughes

  • Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells.

    Christopher J. Ong;Andrew Ming-Lum;Matt Nodwell;Ali Ghanipour

  • Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc.

    Ling Liu;J. E. Damen;R. L. Cutler;G. Krystal

  • Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3-Kinase Activity (∗)

    Jacqueline E. Damen;Robert L. Cutler;Huaiyuan Jiao;Taolin Yi

  • Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.

    G W Chacko;S Tridandapani;J E Damen;L Liu

  • A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice.

    Cheryl D. Helgason;Christian P. Kalberer;Jacqueline E. Damen;Suzanne M. Chappel

Frequent Co-Authors

Connie J. Eaves
Connie J. Eaves University of British Columbia
Michael Huber
Michael Huber University of Zurich
R. Keith Humphries
R. Keith Humphries University of British Columbia
Cheryl D. Helgason
Cheryl D. Helgason BC Cancer Research Centre
Allen C. Eaves
Allen C. Eaves Stemcell Technologies
Raymond J. Andersen
Raymond J. Andersen University of British Columbia
Peter M. Lansdorp
Peter M. Lansdorp University of British Columbia
Vincent Duronio
Vincent Duronio University of British Columbia
Philip W. Majerus
Philip W. Majerus Washington University in St. Louis
Poul H. Sorensen
Poul H. Sorensen University of British Columbia

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