R. Keith Humphries

Overview

Best Publications

• Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

  Morin Rd;Johnson Na;Severson Tm;Mungall Aj

  1905
  Citations

• HOXB4-INDUCED EXPANSION OF ADULT HEMATOPOIETIC STEM CELLS EX VIVO

  Jennifer Antonchuk;Guy Sauvageau;R.Keith Humphries;R.Keith Humphries

  893
  Citations

• Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

  Daniel T Starczynowski;Florian Kuchenbauer;Bob Argiropoulos;Sandy Sung

  800
  Citations

• Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

  G Sauvageau;U Thorsteinsdottir;C J Eaves;H J Lawrence

  757
  Citations

• Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

  Cheryl D. Helgason;Jacqueline E. Damen;Patty Rosten;Rewa Grewal

  706
  Citations

• Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy

  Robert Pawliuk;Karen A. Westerman;Mary E. Fabry;Emmanuel Payen

  704
  Citations

• Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

  Damian B. Yap;Damian B. Yap;Justin Chu;Tobias Berg;Matthieu Schapira

  682
  Citations

• Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

  Iman Fares;Jalila Chagraoui;Yves Gareau;Stéphane Gingras

  586
  Citations

• Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.

  H. Jeffrey Lawrence;H. Jeffrey Lawrence;H. Jeffrey Lawrence;Cheryl D. Helgason;Cheryl D. Helgason;Cheryl D. Helgason;Guy Sauvageau;Guy Sauvageau;Guy Sauvageau;Stephen Fong;Stephen Fong;Stephen Fong

  405
  Citations

• High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays

  Véronique Lecault;Michael VanInsberghe;Sanja Sekulovic;David J H F Knapp

  387
  Citations

• The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation

  Michael Huber;Cheryl D. Helgason;Jacqueline E. Damen;Ling Liu

  378
  Citations

• The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells

  Michael R. Copley;Sonja Babovic;Claudia Benz;David J. H. F. Knapp

  354
  Citations

• Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny.

  Nicolas Pineault;Cheryl D Helgason;H.Jeffrey Lawrence;R.Keith Humphries;R.Keith Humphries

  348
  Citations

• HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation

  Jennifer Antonchuk;Guy Sauvageau;R.Keith Humphries;R.Keith Humphries

  330
  Citations

• The Role of HOX Homeobox Genes in Normal and Leukemic Hematopoiesis

  H. Jeffrey Lawrence;Guy Sauvageau;R. Keith Humphries;Corey Largman

  314
  Citations

• The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

  Christina Schessl;Vijay P.S. Rawat;Monica Cusan;Aniruddha Deshpande

  307
  Citations

• Transfer of the human telomerase reverse transcriptase(TERT) gene into T lymphocytes results in extension of replicative potential

  Nathalie Rufer;Marco Migliaccio;Jennifer Antonchuk;R. Keith Humphries

  264
  Citations

• Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells.

  Hideaki Ohta;Akihisa Sawada;Ji Yoo Kim;Sadao Tokimasa

  262
  Citations

• Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

  H. Jeffrey Lawrence;Julie Christensen;Stephen Fong;Yu-Long Hu

  250
  Citations

• In vitro and in vivo expansion of hematopoietic stem cells

  Guy Sauvageau;Norman N Iscove;R Keith Humphries;R Keith Humphries

  244
  Citations