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Chemistry

D-Index
43
Citations
8897
World Ranking
17088
National Ranking
1235

Overview

John T. Hunt is affiliated with Bristol-Myers Squibb in Germany. Their research activity spans several fields, primarily within Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. The scientist has contributed notably to subfields such as Biological Psychiatry, Molecular Biology, Pharmacology, Oncology, and Behavioral Neuroscience.

Their work addresses topics that include Tryptophan and brain disorders, Stress Responses and Cortisol, Treatment of Major Depression, Bipolar Disorder and Treatment, Pharmacological Receptor Mechanisms and Effects, Pharmacogenetics and Drug Metabolism, as well as Immunotherapy and Immune Responses.

Frequent publication venues for their research include:

  • ACS Medicinal Chemistry Letters
  • Journal for ImmunoTherapy of Cancer
  • Molecular Cancer Therapeutics
  • Journal of Medicinal Chemistry
  • Bioorganic & Medicinal Chemistry Letters

Recent publications reflect an emphasis on cancer immunotherapy and pharmacological inhibitor development. Selected papers include:

  • Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor, 2021, Journal for ImmunoTherapy of Cancer
  • Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor, 2020, Molecular Cancer Therapeutics
  • Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design, 2021, Journal of Medicinal Chemistry
  • Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1, 2021, ACS Medicinal Chemistry Letters
  • Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy, 2021, ACS Medicinal Chemistry Letters

The scientist collaborates frequently with other researchers, including Aaron Balog, Sarah C. Traeger, Johnni Gullo-Brown, Tai-an Lin, and Derrick Maley.

Best Publications

  • Inhibitors of farnesyl protein transferase

    Rajeev S. Bhide;Charles Z. Ding;John T. Hunt;Soong-Hoon Kim

  • Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

    Louis J. Lombardo;Francis Y. Lee;Ping Chen;Derek Norris

  • Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

    Gretchen M. Schroeder;Yongmi An;Zhen-Wei Cai;Xiao-Tao Chen

  • N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.

    Raj N Misra;Hai-yun Xiao;Kyoung S Kim;Songfeng Lu

  • Venous smooth muscle contains vasoconstrictor ETB-like receptors

    Suzanne Moreland;Diane M. McMullen;Carol L. Delaney;Ving G. Lee

  • Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.

    Micah T. Nelp;Patrick A. Kates;John T. Hunt;John A. Newitt

  • The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.

    Stein Pd;Hunt Jt;Floyd Dm;Moreland S

  • Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-Ray Crystallographic Analysis, and Biological Activities

    Kyoung Soon Kim;S. David Kimball;Raj N. Misra;David B. Rawlins

  • Pyrrolotriazine inhibitors of kinases

    John T. Hunt;Rajeev S. Bhide;Robert Michael Borzilleri;Ligang Qian

  • Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.

    Rajeev S. Bhide;Zhen-Wei Cai;Yong-Zheng Zhang;Ligang Qian

  • Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215).

    Zhen-wei Cai;Yongzheng Zhang;Robert M. Borzilleri;Ligang Qian

  • Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.

    John T. Hunt;Charles Z. Ding;Roberta Batorsky;Mark Bednarz

  • Aminothiazole inhibitors of cyclin dependent kinases

    Kyoung S. Kim;S. David Kimball;Zhen-wei Cai;David B. Rawlins

  • Discovery of the Pyrrolo[2,1-f][1,2,4]triazine Nucleus as a New Kinase Inhibitor Template

    John T Hunt;Toomas Mitt;Robert Borzilleri;Johnni Gullo-Brown

  • Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.

    Kyoung Soon Kim;Liping Zhang;Robert Schmidt;Zhen-Wei Cai

  • Discovery of ixabepilone.

    John T. Hunt

  • Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.

    K S Kim;J S Sack;J S Tokarski;L Qian

  • Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models.

    Maria Jure-Kunkel;Gregg Masters;Emel Girit;Gennaro Dito

  • Sulfonamide endothelin antagonists

    Philip D. Stein;John T. Hunt;Natesan Murugesan

  • Potent, Cell Active, Non-Thiol Tetrapeptide Inhibitors of Farnesyltransferase

    John T. Hunt;Ving G. Lee;Katerina Leftheris;Bernd Seizinger

  • Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

    Ashvinikumar V. Gavai;Claude Quesnelle;Derek Norris;Wen-Ching Han

Frequent Co-Authors

Joel C. Barrish
Joel C. Barrish Bristol-Myers Squibb (Germany)
George L. Trainor
George L. Trainor Bristol-Myers Squibb (Germany)
Yufen Zhao
Yufen Zhao Xiamen University
Marco M. Gottardis
Marco M. Gottardis NKGen Biotech Inc
Andrew V. Kossenkov
Andrew V. Kossenkov The Wistar Institute
Bernd R. Seizinger
Bernd R. Seizinger Oxford Biotherapeutics (United Kingdom)
Dmitry I. Gabrilovich
Dmitry I. Gabrilovich AstraZeneca (United Kingdom)
Scott I. Abrams
Scott I. Abrams Roswell Park Cancer Institute
Niels H. Andersen
Niels H. Andersen University of Washington

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