Joel C. Barrish

Overview

Best Publications

• Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

  Louis J. Lombardo;Francis Y. Lee;Ping Chen;Derek Norris

  1295
  Citations

• 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.

  Jagabandhu Das;Ping Chen;Derek Norris;Ramesh Padmanabha

  563
  Citations

• Cyclic protein tyrosine kinase inhibitors

  Jagabandhu Das;Ramesh Padmanabha;Ping Chen;Derek J. Norris

  438
  Citations

• A new facile method for the synthesis of 1-arylimidazole-5-carboxylates

  Bang-Chi Chen;Mark S Bednarz;Rulin Zhao;Joseph E Sundeen

  237
  Citations

• A stereoselective synthesis of 1,3-diol derivatives and application to the ansa bridge of rifamycin S

  W. Clark Still;Joel C. Barrish

  212
  Citations

• Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.

  Rajeev S. Bhide;Zhen-Wei Cai;Yong-Zheng Zhang;Ligang Qian

  203
  Citations

• Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215).

  Zhen-wei Cai;Yongzheng Zhang;Robert M. Borzilleri;Ligang Qian

  192
  Citations

• Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation

  Tai An Lin;Kim W. McIntyre;Jagabandhu Das;Chunjian Liu

  188
  Citations

• Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56lck inhibitors

  Jagabandhu Das;Robert V. Moquin;James Lin;Chunjian Liu

  172
  Citations

• Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.

  Scott H. Watterson;George V. De Lucca;Qing Shi;Charles M. Langevine

  162
  Citations

• METHODS OF TREATING p38 KINASE-ASSOCIATED CONDITIONS AND PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS

  Katerina Leftheris;Joel Barrish;John Hynes;Stephen T. Wrobleski

  139
  Citations

• Heterocyclo-substituted imidazopyrazine protein tyrosine kinase inhibitors

  Ping Chen;Derek J. Norris;Joel C. Barrish;Edwin J. Iwanowicz

  134
  Citations

• Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.

  Jagabandhu Das;Joseph A. Furch;Chunjian Liu;Robert V. Moquin

  117
  Citations

• Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.

  John Hynes;Alaric J. Dyckman;Shuqun Lin;Stephen T. Wrobleski

  112
  Citations

• Dual action inhibitors

  Donald S. Karanewsky;Joel C. Barrish;Edward W. Petrillo;Jeffrey A. Robl

  111
  Citations

• Amino Diol HIV Protease Inhibitors. 1. Design, Synthesis, and Preliminary SAR

  Joel C. Barrish;Eric Gordon;Masud Alam;Pin-Fang Lin

  101
  Citations

• 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase.

  Chunjian Liu;Stephen T. Wrobleski;James Lin;Gulzar Ahmed

  96
  Citations

• Cupric bromide mediated oxidation of 4-carboxyoxazolines to the corresponding oxazoles

  Joel C. Barrish;Janak Singh;Steven H. Spergel;Wen Ching Han

  95
  Citations

• Substituted biphenyl sulfonamide endothelin antagonists

  Natesan Murugesan;Joel C. Barrish;Philip D. Stein

  94
  Citations

• Imidazoquinoxaline protein tyrosine kinase inhibitors

  Joel C. Barrish;Ping Chen;Jagabandhu Das;Edwin J. Iwanowicz

  93
  Citations