Silvia Schenone

Overview

Best Publications

• New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities

  Silvia Schenone;Chiara Brullo;Olga Bruno;Francesco Bondavalli

  296
  Citations

• Vascular Endothelial Growth Factor (VEGF) Receptors: Drugs and New Inhibitors

  Francesca Musumeci;Marco Radi;Chiara Brullo;Silvia Schenone

  190
  Citations

• Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies.

  Silvia Schenone;Marco Radi;Francesca Musumeci;Chiara Brullo

  179
  Citations

• ATP-Competitive Inhibitors of mTOR: An Update

  S. Schenone;C. Brullo;F. Musumeci;M. Radi

  152
  Citations

• Guanylated diamines, triamines, and polyamines: chemistry and biological properties.

  Daniele Castagnolo;Silvia Schenone;Maurizio Botta

  148
  Citations

• Antiangiogenic agents: an update on small molecule VEGFR inhibitors.

  Silvia Schenone;Francesco Bondavalli;M. Botta

  124
  Citations

• Synthesis, antimicrobial activity and molecular modeling studies of halogenated 4-[1H-imidazol-1-yl(phenyl)methyl]-1,5-diphenyl-1H-pyrazoles.

  Giulia Menozzi;Luisa Merello;Paola Fossa;Silvia Schenone

  121
  Citations

• New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation

  Silvia Schenone;Olga Bruno;Angelo Ranise;Francesco Bondavalli

  116
  Citations

• 3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as anti-inflammatory and analgesic agents.

  Silvia Schenone;Olga Bruno;Angelo Ranise;Francesco Bondavalli

  115
  Citations

• Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.

  Fabio Carraro;Antonella Naldini;Annalisa Pucci;Giada A. Locatelli

  112
  Citations

• Progress in 5H[1]benzopyrano[4,3-d]pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity.

  Olga Bruno;Chiara Brullo;Silvia Schenone;Angelo Ranise

  110
  Citations

• Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones.

  Olga Bruno;Chiara Brullo;Silvia Schenone;Francesco Bondavalli

  109
  Citations

• Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice.

  Fabrizio Manetti;Annalisa Santucci;Giada A. Locatelli;Giovanni Maga

  101
  Citations

• Novel dual Src/Abl inhibitors for hematologic and solid malignancies

  Silvia Schenone;Chiara Brullo;Francesca Musumeci;Maurizio Botta

  96
  Citations

• Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors

  Marco Radi;Federico Falchi;Anna Garbelli;Alberta Samuele

  95
  Citations

• Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines.

  Silvia Schenone;Chiara Brullo;Olga Bruno;Francesco Bondavalli

  94
  Citations

• Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines.

  Fabrizio Manetti;Chiara Brullo;Matteo Magnani;Francesca Mosci

  94
  Citations

• Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line.

  Silvia Schenone;Olga Bruno;Francesco Bondavalli;Angelo Ranise

  92
  Citations

• Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study.

  Marco Radi;Elena Dreassi;Chiara Brullo;Emmanuele Crespan

  91
  Citations

• Recent highlights in the synthesis of highly functionalized pyrimidines.

  Marco Radi;Silvia Schenone;Maurizio Botta;Maurizio Botta

  89
  Citations