Federico Da Settimo

Overview

Best Publications

• Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

  Alma Martelli;Lara Testai;Valentina Citi;Alice Marino

  182
  Citations

• 11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain.

  Masamichi Ikawa;Talakad G. Lohith;Stal Shrestha;Sanjay Telu

  182
  Citations

• Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity.

  Concettina La Motta;Stefania Sartini;Laura Mugnaini;Francesca Simorini

  175
  Citations

• Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications

  Rosaria Ottanà;Rosanna Maccari;Marco Giglio;Antonella Del Corso

  140
  Citations

• Inhibition of Adenosine Deaminase Attenuates Inflammation in Experimental Colitis

  Luca Antonioli;Matteo Fornai;Rocchina Colucci;Narcisa Ghisu

  137
  Citations

• Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.

  Paolo Zanotti-Fregonara;Yi Zhang;Kimberly J. Jenko;Robert L. Gladding

  133
  Citations

• Sampling protein motion and solvent effect during ligand binding

  Vittorio Limongelli;Luciana Marinelli;Sandro Cosconati;Concettina La Motta

  133
  Citations

• Synthesis, in vitro antiproliferative activity and DNA-interaction of benzimidazoquinazoline derivatives as potential anti-tumor agents.

  Lisa Dalla Via;Ornella Gia;Sebastiano Marciani Magno;Antonio Da Settimo

  117
  Citations

• The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities

  Marco Robello;Elisabetta Barresi;Emma Baglini;Silvia Salerno

  111
  Citations

• Novel Pyrazolopyrimidine Derivatives as Tyrosine Kinase Inhibitors with Antitumoral Activity in Vitro and in Vivo in Papillary Dedifferentiated Thyroid Cancer

  Alessandro Antonelli;Guido Bocci;Concettina La Motta;Silvia Martina Ferrari

  105
  Citations

• Anxiolytic-like Effects of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides by Modulation of Translocator Protein Promoting Neurosteroid Biosynthesis

  Federico Da Settimo;Francesca Simorini;Sabrina Taliani;Concettina La Motta

  101
  Citations

• N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides. A New Class of Potent and Selective Ligands at the Peripheral Benzodiazepine Receptor

  Giampaolo Primofiore;Federico Da Settimo;Sabrina Taliani;Francesca Simorini

  97
  Citations

• Indole amide derivatives : synthesis, structure-activity relationships and molecular modelling studies of a new series of histamine H1-receptor antagonists

  Sandra Battaglia;Enrico Boldrini;Federico Da Settimo;Giulio Dondio

  83
  Citations

• Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2).

  Enrico Perspicace;Valérie Jouan-Hureaux;Rino Ragno;Flavio Ballante

  82
  Citations

• TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy.

  Barbara Costa;Eleonora Da Pozzo;Chiara Giacomelli;Elisabetta Barresi

  82
  Citations

• 3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.

  Federico Da Settimo;Giampaolo Primofiore;Sabrina Taliani;Anna Maria Marini

  80
  Citations

• Microglial pro-inflammatory and anti-inflammatory phenotypes are modulated by translocator protein activation

  Eleonora Da Pozzo;Chiara Tremolanti;Barbara Costa;Chiara Giacomelli

  78
  Citations

• Synthesis, DNA binding and in vitro antiproliferative activity of purinoquinazoline, pyridopyrimidopurine and pyridopyrimidobenzimidazole derivatives as potential antitumor agents

  Antonio Da Settimo;Federico Da Settimo;Anna Maria Marini;Giampaolo Primofiore

  75
  Citations

• Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42‐induced neurodegeneration

  Ran Lin;Ran Lin;Alessia Angelin;Federico Da Settimo;Claudia Martini

  74
  Citations

• Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma

  Simona Daniele;Sabrina Taliani;Eleonora Da Pozzo;Chiara Giacomelli

  71
  Citations

• Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A3 Adenosine Receptor Antagonists

  Barbara Cosimelli;Giovanni Greco;Marina Ehlardo;Ettore Novellino

  69
  Citations