George L. Trainor

Overview

Best Publications

• MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.

  John V. Duncia;Joseph B. Santella;C.Anne Higley;William J. Pitts

  538
  Citations

• Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation

  Thais M. Sielecki;John F. Boylan;Pamela A. Benfield;George L. Trainor

  463
  Citations

• The importance of plasma protein binding in drug discovery

  George L Trainor

  435
  Citations

• Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

  Gretchen M. Schroeder;Yongmi An;Zhen-Wei Cai;Xiao-Tao Chen

  429
  Citations

• Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.

  Jeffrey W. Corbett;Soo S. Ko;James D. Rodgers;Lisa A. Gearhart

  395
  Citations

• Optimization of metallocene substrates for .beta.-cyclodextrin reactions

  Ronald Breslow;George Trainor;Akihiko Ueno

  203
  Citations

• Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.

  Jay A. Markwalder;Marc R. Arnone;Pamela A. Benfield;Michael Boisclair

  166
  Citations

• High acylation rates and enantioselectivity with cyclodextrin complexes of rigid substrates

  George L. Trainor;Ronald Breslow

  165
  Citations

• Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1

  Jeffrey W. Corbett;Soo S. Ko;James D. Rodgers;Susan Jeffrey

  162
  Citations

• Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity

  Charles F. Albright;Nilsa Graciani;Wei Han;Eddy Yue

  156
  Citations

• 4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist.

  Liqi He;Paul J. Gilligan;Robert Zaczek;Lawrence W. Fitzgerald

  149
  Citations

• Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.

  Kyoung Soon Kim;Liping Zhang;Robert Schmidt;Zhen-Wei Cai

  141
  Citations

• Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.

  Mark D. Wittman;Joan M. Carboni;Zheng Yang;Francis Y. Lee

  140
  Citations

• Quinazolines as cyclin dependent kinase inhibitors.

  Thais M. Sielecki;Tricia L. Johnson;Jie Liu;Jodi K. Muckelbauer

  135
  Citations

• The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonist.

  Paul J. Gilligan;Caryn Baldauf;Anthony Cocuzza;Dennis Chidester

  130
  Citations

• Organo-Transition-Metal-Based Approach to the Synthesis of C-Glycosides.

  P. Deshong;G. A. Slough;V. Elango;G. L. Trainor

  114
  Citations

• Organo-transition-metal-based approach to the synthesis of C-glycosides

  Philip DeShong;Greg A. Slough;Varadaraj Elango;George L. Trainor

  114
  Citations

• Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.

  Mona Patel;Robert J McHugh;Beverly C Cordova;Ronald M Klabe

  113
  Citations

• Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).

  Tram Huynh;Zhong Chen;Suhong Pang;Jieping Geng

  113
  Citations

• Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

  Ashvinikumar V. Gavai;Claude Quesnelle;Derek Norris;Wen-Ching Han

  113
  Citations

• Trends in kinase selectivity: insights for target class-focused library screening.

  Shana L. Posy;Mark A. Hermsmeier;Wayne Vaccaro;Karl-Heinz Ott

  111
  Citations