Silencing of microRNAs in vivo with ‘antagomirs’
Jan Krützfeldt;Nikolaus Rajewsky;Ravi Braich;Kallanthottathil G. Rajeev.
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Jürgen Soutschek;Akin Akinc;Birgit Bramlage;Klaus Charisse.
Rational design of cationic lipids for siRNA delivery
Sean C Semple;Akin Akinc;Jianxin Chen;Ammen P Sandhu.
Nature Biotechnology (2010)
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akin Akinc;Andreas Zumbuehl;Andreas Zumbuehl;Michael Goldberg;Elizaveta S Leshchiner.
Nature Biotechnology (2008)
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
Christian Wolfrum;Shuanping Shi;K Narayanannair Jayaprakash;Muthusamy Jayaraman.
Nature Biotechnology (2007)
Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
Jayaprakash K. Nair;Jennifer L. S. Willoughby;Amy Chan;Klaus Charisse.
Journal of the American Chemical Society (2014)
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.
Akin Akinc;William Querbes;Soma De;June Qin.
Molecular Therapy (2010)
Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo
Muthusamy Jayaraman;Steven M. Ansell;Barbara L. Mui;Ying K. Tam.
Angewandte Chemie (2012)
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
Maria Frank-Kamenetsky;Aldo Grefhorst;Norma N. Anderson;Timothy S. Racie.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver
Akin Akinc;Michael Goldberg;June Qin;J Robert Dorkin.
Molecular Therapy (2009)
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