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Biology and Biochemistry

D-Index
57
Citations
26722
World Ranking
13512
National Ranking
5730

Overview

Kallanthottathil G. Rajeev is a researcher affiliated with Alnylam Pharmaceuticals in the United States. Their work spans several areas within biochemistry, genetics, and molecular biology, with a focus on molecular biology and related subfields including rheumatology, public health, cardiovascular medicine, and immunology.

Their research topics comprise RNA interference and gene delivery, CRISPR and genetic engineering, DNA and nucleic acid chemistry, advanced biosensing and bioanalysis techniques, systemic lupus erythematosus research, RNA and protein synthesis mechanisms, and mosquito-borne diseases and control.

Rajeev has contributed to multiple research publications across notable scientific journals. Frequent publication venues include:

  • Journal of Medicinal Chemistry
  • Nature
  • Nature Communications
  • Nucleic Acids Research
  • Journal of the American Chemical Society

Recent papers authored or co-authored by Rajeev include:

  • In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates, 2021, Nature
  • GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy, 2023, Nature Communications
  • Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo, 2021, Nucleic Acids Research
  • Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs, 2023, Journal of the American Chemical Society
  • Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways, 2023, Journal of Medicinal Chemistry

Their frequent co-authors include:

  • Muthiah Manoharan
  • Klaus Charissé
  • Martin Egli
  • Kiran Musunuru
  • Alexandra C. Chadwick

Rajeev's research interest is deeply rooted in the study of RNA interference and gene delivery mechanisms, contributing to advancements in CRISPR-based genetic engineering. Their work also explores nucleic acid chemistry modifications that improve the pharmacological profiles and stability of therapeutic molecules.

They have engaged in investigation related to systemic lupus erythematosus and have contributed knowledge pertinent to RNA and protein synthesis mechanisms. Additionally, their research touches on public health topics such as mosquito-borne diseases and control, illustrating a broad interdisciplinary approach to molecular biology and medicine.

Best Publications

  • Silencing of microRNAs in vivo with ‘antagomirs’

    Jan Krützfeldt;Nikolaus Rajewsky;Ravi Braich;Kallanthottathil G. Rajeev

  • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

    Jürgen Soutschek;Akin Akinc;Birgit Bramlage;Klaus Charisse

  • Rational design of cationic lipids for siRNA delivery

    Sean C Semple;Akin Akinc;Jianxin Chen;Ammen P Sandhu

  • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

    Akin Akinc;Andreas Zumbuehl;Andreas Zumbuehl;Michael Goldberg;Elizaveta S Leshchiner

  • Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

    Muthusamy Jayaraman;Steven M. Ansell;Barbara L. Mui;Ying K. Tam

  • Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.

    Akin Akinc;William Querbes;Soma De;June Qin

  • Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

    Christian Wolfrum;Shuanping Shi;K Narayanannair Jayaprakash;Muthusamy Jayaraman

  • Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

    Jayaprakash K. Nair;Jennifer L. S. Willoughby;Amy Chan;Klaus Charisse

  • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

    Maria Frank-Kamenetsky;Aldo Grefhorst;Norma N. Anderson;Timothy S. Racie

  • Specificity, duplex degradation and subcellular localization of antagomirs

    Jan Krützfeldt;Satoru Kuwajima;Ravi Braich;Kallanthottathil G. Rajeev

  • In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.

    Kiran Musunuru;Alexandra C. Chadwick;Taiji Mizoguchi;Sara P. Garcia

  • Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

    Martin A Maier;Muthusamy Jayaraman;Shigeo Matsuda;Ju Liu

  • Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

    Marian DiFiglia;Miguel Sena-Esteves;Kathryn O. Chase;Ellen Sapp

  • Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

    Akin Akinc;Michael Goldberg;June Qin;J Robert Dorkin

  • Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

    Barbara L Mui;Ying K Tam;Muthusamy Jayaraman;Steven M Ansell

  • An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

    Alfica Sehgal;Scott Barros;Lacramioara Ivanciu;Brian Cooley

  • siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

    Shigeo Matsuda;Kristofer Keiser;Jayaprakash K. Nair;Klaus Charisse

  • Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

    Donald J. Foster;Christopher R. Brown;Sarfraz Shaikh;Casey Trapp

  • Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.

    Jayaprakash K. Nair;Husain Attarwala;Alfica Sehgal;Qianfan Wang

  • Chemically modified oligonucleotides

    Muthiah Manoharan;Venkitasamy Kesavan;Kallanthottathil G. Rajeev

Frequent Co-Authors

Muthiah Manoharan
Muthiah Manoharan Alnylam Pharmaceuticals (United States)
Martin Maier
Martin Maier Alnylam Pharmaceuticals (United States)
Martin Egli
Martin Egli Vanderbilt University
Michael J. Hope
Michael J. Hope University of British Columbia
Pieter R. Cullis
Pieter R. Cullis University of British Columbia
Victor Koteliansky
Victor Koteliansky Skolkovo Institute of Science and Technology
Antonin de Fougerolles
Antonin de Fougerolles Alnylam Pharmaceuticals (United States)
Markus Stoffel
Markus Stoffel University of Geneva
Marco A. Ciufolini
Marco A. Ciufolini University of British Columbia

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