World's Best Scientists 2026 revealed!

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Chemistry

D-Index
80
Citations
18611
World Ranking
3503
National Ranking
1143

Biology and Biochemistry

D-Index
80
Citations
18533
World Ranking
4168
National Ranking
2041

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Martin Egli is affiliated with Vanderbilt University in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with substantial contributions to molecular biology, materials chemistry, and organic chemistry. The scientist's work also intersects with infectious diseases and cancer research.

The main topics of their research include:

  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • RNA and protein synthesis mechanisms
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • RNA modifications and cancer

Key publications by Martin Egli highlight their involvement in nucleic acid therapeutics and RNA interference. Selected recent papers include:

  • Chemistry, structure and function of approved oligonucleotide therapeutics, 2023, Nucleic Acids Research
  • Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency, 2023, RNA

Other important papers in related fields where they are not the primary author but connected through research context include works on:

  • From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization, 2022, Nucleic Acids Research
  • Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo, 2021, Nucleic Acids Research
  • Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease, 2020, Nucleic Acids Research

Frequent publication venues where Martin Egli has contributed include:

  • Nucleic Acids Research
  • The Cambridge Structural Database
  • Organic Letters
  • Biochemistry
  • Journal of the American Chemical Society

The scientist has collaborated extensively with multiple coauthors, including:

  • Muthiah Manoharan
  • Joel M. Harp
  • Pradeep S. Pallan
  • Mark K. Schlegel
  • Dhrubajyoti Datta

In 2009, Martin Egli was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Chemistry, structure and function of approved oligonucleotide therapeutics

    Unknown

  • Lone pair-aromatic interactions: to stabilize or not to stabilize.

    Martin Egli;Sanjay Sarkhel

  • Recent Structural Insights into Cytochrome P450 Function.

    F. Peter Guengerich;Michael R. Waterman;Martin Egli

  • RNA Hydration: A Detailed Look†,‡

    Martin Egli;Stefan Portmann;Nassim Usman

  • Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot.

    Li Su;Liqing Chen;Liqing Chen;Martin Egli;James M. Berger;James M. Berger

  • Stereoelectronic effects of deoxyribose O4' on DNA conformation.

    Martin Egli;Reinhard V. Gessner

  • Atomic-resolution crystal structures of B-DNA reveal specific influences of divalent metal ions on conformation and packing.

    George Minasov;Valentina Tereshko;Martin Egli

  • DNA-cation interactions: quo vadis?

    Martin Egli

  • A "Hydrat-Ion" Spine in a B-DNA Minor Groove

    Valentina Tereshko;George Minasov;Martin Egli

  • Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.

    M Teplova;G Minasov;V Tereshko;G B Inamati

  • Visualizing a circadian clock protein: crystal structure of KaiC and functional insights.

    Rekha Pattanayek;Jimin Wang;Tetsuya Mori;Yao Xu

  • Crystal structure of a conformation-selective casein kinase-1 inhibitor.

    Neda Mashhoon;Anthony J. DeMaggio;Valentina Tereshko;Stephen C. Bergmeier

  • The Dickerson-Drew B-DNA Dodecamer Revisited-At Atomic Resolution

    Valentina Tereshko;George Minasov;Martin Egli

  • Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA

    Pradeep S. Pallan;Emily M. Greene;Paul Andrei Jicman;Rajendra K. Pandey

  • Unique Gene‐Silencing and Structural Properties of 2′‐Fluoro‐Modified siRNAs

    Muthiah Manoharan;Akin Akinc;Rajendra K. Pandey;June Qin

  • Inter-strand C-H...O hydrogen bonds stabilizing four-stranded intercalated molecules: stereoelectronic effects of O4' in cytosine-rich DNA

    Imre Berger;Martin Egli;Alexander Rich

  • DNA Adduct Bypass Polymerization by Sulfolobus Solfataricus DNA Polymerase Dpo4: Analysis and Crystal Structures of Multiple Base Pair Substitution and Frameshift Products with the Adduct 1,N2-Ethenoguanine.

    Hong Zang;Angela K. Goodenough;Jeong-Yun Choi;Adriana Irimia

  • Identification of key phosphorylation sites in the circadian clock protein KaiC by crystallographic and mutagenetic analyses.

    Yao Xu;Tetsuya Mori;Rekha Pattanayek;Sabuj Pattanayek

  • Conformational influence of the ribose 2'-hydroxyl group: crystal structures of DNA-RNA chimeric duplexes

    Martin Egli;Nassim Usman;Alexander Rich

  • Stabilizing effects of the RNA 2′-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2′-O-methylated adenosines

    Paolo Lubini;Werner Zürcher;Martin Egli

  • Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments

    Valentina Tereshko;Christopher J. Wilds;George Minasov;Thaza P. Prakash

  • Elucidating the Ticking of an In Vitro Circadian Clockwork

    Tetsuya Mori;Dewight R Williams;Mark O Byrne;Ximing Qin

Frequent Co-Authors

F. Peter Guengerich
F. Peter Guengerich Vanderbilt University
Valentina Tereshko
Valentina Tereshko University of Chicago
Muthiah Manoharan
Muthiah Manoharan Alnylam Pharmaceuticals (United States)
Martin Maier
Martin Maier Alnylam Pharmaceuticals (United States)
Carl Hirschie Johnson
Carl Hirschie Johnson Vanderbilt University
Phoebe L. Stewart
Phoebe L. Stewart Case Western Reserve University
Loren Dean Williams
Loren Dean Williams Georgia Institute of Technology
Eric E. Swayze
Eric E. Swayze Ionis Pharmaceuticals (United States)
Imre Berger
Imre Berger University of Bristol

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