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Immunology

D-Index
67
Citations
20818
World Ranking
2649
National Ranking
1266

Overview

Willem W. Overwijk is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research is primarily situated within the fields of Medicine and Immunology and Microbiology, with significant contributions across several subfields including Immunology, Oncology, Neurology, Molecular Biology, and Genetics.

Their work focuses on multiple key topics such as CAR-T cell therapy research, Cancer Immunotherapy and Biomarkers, Immunotherapy and Immune Responses, Immune Cell Function and Interaction, Neuroblastoma Research and Treatments, Immune cells in cancer, and Microtubule and mitosis dynamics.

Willem W. Overwijk has published extensively, with notable recent papers including:

  • Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy, 2020, Nature Communications
  • Engineering IL-2 to Give New Life to T Cell Immunotherapy, 2020, Annual Review of Medicine
  • Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti-PD-1 Refractory Melanoma, 2021, Cancer Discovery
  • LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade, 2022, Journal of Clinical Investigation
  • Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity, 2020, Cancer Immunology Immunotherapy

The frequent co-authors collaborating with Overwijk include Manisha Singh, Cara Haymaker, Adi Diab, Jason Roszik, and Patrick Hwu.

Publications by Overwijk have appeared regularly in venues such as The Journal of Immunology, Blood Advances, Frontiers in Immunology, Transplantation and Cellular Therapy, and Cancer Research.

Best Publications

  • Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

    Weiyi Peng;Jie Qing Chen;Chengwen Liu;Shruti Malu

  • Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells

    Willem W. Overwijk;Marc R. Theoret;Steven E. Finkelstein;Deborah R. Surman

  • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma

    Dennie Tompers Frederick;Adriano Piris;Alexandria P. Cogdill;Zachary A. Cooper

  • Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade.

    Pei Ling Chen;Whijae Roh;Alexandre Reuben;Zachary A. Cooper

  • T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

    Natalia Martin-Orozco;Pawel Muranski;Yeonseok Chung;Xuexian O. Yang

  • CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4 T helper cells and hindered by naturally occurring T regulatory cells.

    Paul A. Antony;Ciriaco A. Piccirillo;Akgül Akpinarli;Steven E. Finkelstein

  • GP100/PMEL 17 IS A MURINE TUMOR REJECTION ANTIGEN : INDUCTION OF SELF -REACTIVE, TUMORICIDAL T CELLS USING HIGH-AFFINITY, ALTERED PEPTIDE LIGAND

    Willem W. Overwijk;Allan Tsung;Kari R. Irvine;Maria R. Parkhurst

  • B16 as a mouse model for human melanoma.

    Willem W. Overwijk;Nicholas P. Restifo

  • Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4+ T lymphocytes

    Willem W. Overwijk;David S. Lee;Deborah R. Surman;Kari R. Irvine

  • PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines

    Weiyi Peng;Chengwen Liu;Chunyu Xu;Yanyan Lou

  • Persistent antigen at vaccination sites induces tumor-specific CD8 + T cell sequestration, dysfunction and deletion

    Yared Hailemichael;Zhimin Dai;Nina Jaffarzad;Yang Ye

  • Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine Comparison of Prophylaxis and Therapy

    A. Van Elsas;R. P M Sutmuller;A. A. Hurwitz;J. Ziskin

  • Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells.

    Vincenzo Bronte;Michael Wang;Willem W. Overwijk;Deborah R. Surman

  • BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.

    Chengwen Liu;Weiyi Peng;Chunyu Xu;Yanyan Lou

  • Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy

    Tiffany R. Hodges;Martina Ott;Joanne Xiu;Zoran Gatalica

  • Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice

    Chengwen Liu;Yanyan Lou;Gregory Lizée;Hong Qin

  • Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function

    Young Hee Lee;Natalia Martin-Orozco;Natalia Martin-Orozco;Peilin Zheng;Jing Li

  • The immune system in cancer metastasis: friend or foe?

    Louise M.E. Janssen;Emma E. Ramsay;Craig D. Logsdon;Willem W. Overwijk

  • Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy.

    Xiaohong Wang;Jonathan E. Schoenhals;Ailin Li;David R. Valdecanas

  • Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice

    Hong Qin;Beatrisa Lerman;Ippei Sakamaki;Guowei Wei

  • Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer

    Brian A. Rabinovich;Yang Ye;Tamara Etto;Jie Qing Chen

Frequent Co-Authors

Patrick Hwu
Patrick Hwu The University of Texas MD Anderson Cancer Center
Nicholas P. Restifo
Nicholas P. Restifo National Institutes of Health
Laszlo Radvanyi
Laszlo Radvanyi Ontario Institute for Cancer Research
Adi Diab
Adi Diab The University of Texas MD Anderson Cancer Center
Steven A. Rosenberg
Steven A. Rosenberg National Institutes of Health
Jennifer A. Wargo
Jennifer A. Wargo The University of Texas MD Anderson Cancer Center
Chantale Bernatchez
Chantale Bernatchez The University of Texas MD Anderson Cancer Center
Michael A. Davies
Michael A. Davies The University of Texas MD Anderson Cancer Center
Padmanee Sharma
Padmanee Sharma The University of Texas MD Anderson Cancer Center
Cara Haymaker
Cara Haymaker The University of Texas MD Anderson Cancer Center

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