Martin Maier

Overview

Best Publications

• Rational design of cationic lipids for siRNA delivery

  Sean C Semple;Akin Akinc;Jianxin Chen;Ammen P Sandhu

  2044
  Citations

• The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

  Akin Akinc;Martin A. Maier;Muthiah Manoharan;Kevin Fitzgerald

  1468
  Citations

• Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

  Jerome Gilleron;William Querbes;Anja Zeigerer;Anna Borodovsky

  1351
  Citations

• Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

  Muthusamy Jayaraman;Steven M. Ansell;Barbara L. Mui;Ying K. Tam

  1261
  Citations

• Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.

  Akin Akinc;William Querbes;Soma De;June Qin

  1248
  Citations

• Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

  Jayaprakash K. Nair;Jennifer L. S. Willoughby;Amy Chan;Klaus Charisse

  1141
  Citations

• Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

  Maria Frank-Kamenetsky;Aldo Grefhorst;Norma N. Anderson;Timothy S. Racie

  805
  Citations

• Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

  Martin A Maier;Muthusamy Jayaraman;Shigeo Matsuda;Ju Liu

  505
  Citations

• Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

  Akin Akinc;Michael Goldberg;June Qin;J Robert Dorkin

  432
  Citations

• Systemically delivered antisense oligomers upregulate gene expression in mouse tissues

  Peter Sazani;Federica Gemignani;Shin-Hong Kang;Martin A. Maier

  380
  Citations

• Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

  Barbara L Mui;Ying K Tam;Muthusamy Jayaraman;Steven M Ansell

  339
  Citations

• Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs

  Peter Sazani;Shin-Hong Kang;Martin A. Maier;Changfu Wei

  299
  Citations

• An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

  Alfica Sehgal;Scott Barros;Lacramioara Ivanciu;Brian Cooley

  290
  Citations

• siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

  Shigeo Matsuda;Kristofer Keiser;Jayaprakash K. Nair;Klaus Charisse

  264
  Citations

• Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

  Donald J. Foster;Christopher R. Brown;Sarfraz Shaikh;Casey Trapp

  242
  Citations

• Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.

  Jayaprakash K. Nair;Husain Attarwala;Alfica Sehgal;Qianfan Wang

  234
  Citations

• Unique Gene‐Silencing and Structural Properties of 2′‐Fluoro‐Modified siRNAs

  Muthiah Manoharan;Akin Akinc;Rajendra K. Pandey;June Qin

  209
  Citations

• Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.

  Maja M. Janas;Mark K. Schlegel;Carole E. Harbison;Vedat O. Yilmaz

  209
  Citations

• Lipid containing formulations

  Muthiah Manoharan;Kallanthottahil G. Rajeev;Akin Akinc;K. Narayanannair Jayaprakash

  209
  Citations

• Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.

  Christopher R Brown;Swati Gupta;June Qin;Timothy Racie

  191
  Citations