World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
46
Citations
7809
World Ranking
16037
National Ranking
2474

Overview

Meiyu Geng is affiliated with the Chinese Academy of Sciences in China and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research encompasses a range of subfields including molecular biology, oncology, immunology, materials chemistry, and pulmonary and respiratory medicine.

The scientist's main areas of study cover several critical topics such as interferon and immune responses, crystallization and solubility studies, X-ray diffraction in crystallography, lung cancer treatments and mutations, viral infections and vectors, epigenetics and DNA methylation, and cytokine signaling pathways and interactions.

Frequent coauthors in their publications include:

  • Zuoquan Xie
  • Jian Ding
  • Jing Ai
  • Xiyuan Wang
  • Wenhu Duan

Meiyu Geng has published regularly in a variety of scientific journals, with key venues including:

  • The Cambridge Structural Database
  • European Journal of Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • Acta Pharmacologica Sinica
  • PubMed

Some recent papers authored or coauthored by Meiyu Geng are:

  • A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer's dementia, 2021, Alzheimer's Research & Therapy
  • Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance, 2020, Molecular Cancer
  • A phase II randomized trial of sodium oligomannate in Alzheimer's dementia, 2020, Alzheimer's Research & Therapy
  • Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis, 2022, Kidney Diseases
  • Discovery of Novel Pyrrolo[2,3-d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors, 2021, Journal of Medicinal Chemistry

Their scientific output reflects a balance of clinical trials, drug discovery, and molecular mechanism studies, often focusing on neurodegenerative diseases, cancer therapies, and immune-related pathways.

Best Publications

  • Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease

    Qin Nie;Xiao-guang Du;Mei-yu Geng;Mei-yu Geng

  • Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms.

    Ying Fan;Jinfeng Hu;Jing Li;Zhao Yang

  • Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats

    Unknown

  • Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation.

    Qiaoshi Lian;Jun Xu;Shanshan Yan;Shanshan Yan;Min Huang

  • Synthesis and c-Met Kinase Inhibition of 3,5-Disubstituted and 3,5,7-Trisubstituted Quinolines: Identification of 3-(4-Acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a Novel Anticancer Agent

    Yuanxiang Wang;Jing Ai;Ying Wang;Yi Chen

  • Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling

    Shuai Wang;Xun Huang;Danni Sun;Xianliang Xin

  • Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine790 → Methionine790 Mutant

    Shaohua Chang;Lianwen Zhang;Lianwen Zhang;Shilin Xu;Jinfeng Luo

  • Oligomannurarate sulfate, a novel heparanase inhibitor simultaneously targeting basic fibroblast growth factor, combats tumor angiogenesis and metastasis

    Huajun Zhao;Haiying Liu;Yi Chen;Xianliang Xin

  • One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody–drug conjugates

    Feng Tang;Yang Yang;Yang Yang;Yubo Tang;Yubo Tang;Shuai Tang

  • Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

    Nan Jin;Aiwei Bi;Xiaojing Lan;Jun Xu

  • Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin

    Yun-Guang Tong;Xiong-Wen Zhang;Mei-Yu Geng;Jian-Ming Yue

  • Acidic oligosaccharide sugar chain, a marine-derived acidic oligosaccharide, inhibits the cytotoxicity and aggregation of amyloid beta protein.

    Jinfeng Hu;Meiyu Geng;Jing Li;Xianliang Xin

  • Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.

    Li-Gen Lin;Hua Xie;Hong-Lin Li;Lin-Jiang Tong

  • Penibruguieramine A, a novel pyrrolizidine alkaloid from the endophytic fungus Penicillium sp. GD6 associated with Chinese mangrove Bruguiera gymnorrhiza.

    Zhen Fang Zhou;Tibor Kurtán;Xiao Hong Yang;Attila Mándi

  • CTC clusters induced by heparanase enhance breast cancer metastasis

    Rong-rui Wei;Dan-ni Sun;Hong Yang;Juan Yan

  • Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors

    Yifu Liu;Zuoquan Xie;Dan Zhao;Jin Zhu

  • R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II.

    Hong Zhu;Min Huang;Fan Yang;Yi Chen

  • Sesquiterpenes and dimeric sesquiterpenoids from Sarcandra glabra.

    Xiu-Feng He;Sheng Yin;Yin-Chun Ji;Zu-Shang Su

  • O-GlcNAcylation of Cofilin Promotes Breast Cancer Cell Invasion

    Xun Huang;Qiuming Pan;Danni Sun;Wei Chen

  • Discovery of Substituted 1H-Pyrazolo[3,4-b]pyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors

    Bin Zhao;Yixuan Li;Pan Xu;Yang Dai

  • Multiple and multivalent interactions of novel anti-AIDS drug candidates, sulfated polymannuronate (SPMG)-derived oligosaccharides, with gp120 and their anti-HIV activities

    Haiying Liu;Meiyu Geng;Xianliang Xin;Fuchuan Li

  • Discovery of 3-(5'-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation.

    Wei Yan;Xinyi Wang;Yang Dai;Bin Zhao

  • Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

    Jie Zhang;Pengxing He;Yong Xi;Meiyu Geng

  • JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification

    Wenyi Sun;Zuoquan Xie;Yifu Liu;Dan Zhao

  • Cytotoxic sesquiterpenoids from Sarcandra glabra

    Gang Ni;Hua Zhang;Hong-Chun Liu;Sheng-Ping Yang

Frequent Co-Authors

Hualiang Jiang
Hualiang Jiang Chinese Academy of Sciences
Hong Liu
Hong Liu Shandong University
Cheng Luo
Cheng Luo Chinese Academy of Sciences
Lei Jiang
Lei Jiang Chinese Academy of Sciences
Mingyue Zheng
Mingyue Zheng Chinese Academy of Sciences
Jian-Min Yue
Jian-Min Yue Chinese Academy of Sciences
Ke Ding
Ke Ding Jinan University
Tao Zhang
Tao Zhang Chinese Academy of Sciences
Jian Li
Jian Li ShanghaiTech University
Lei Wang
Lei Wang University of California, San Francisco

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