Ke Ding

Overview

Best Publications

• Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

  Ke Ding;Yipin Lu;Zaneta Nikolovska-Coleska;Guoping Wang

  844
  Citations

• Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

  Ke Ding;Yipin Lu;Zaneta Nikolovska-Coleska;Su Qiu

  777
  Citations

• Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation of the NF-κB Pathway and Generation of Reactive Oxygen Species

  Yanli Jin;Zhongzheng Lu;Ke Ding;Juan Li

  354
  Citations

• Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

  James D. Vasta;Cesear R. Corona;Jennifer Wilkinson;Chad A. Zimprich

  275
  Citations

• Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway

  Xiaomei Ren;Lei Duan;Qiang He;Zhang Zhang

  253
  Citations

• Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.

  Xiaomei Ren;Xiaofen Pan;Zhang Zhang;Deping Wang;Deping Wang

  232
  Citations

• Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction

  Shanghai Yu;Dongguang Qin;Sanjeev Shangary;Jianyong Chen

  222
  Citations

• Adipocyte Fatty Acid-binding Protein Modulates Inflammatory Responses in Macrophages through a Positive Feedback Loop Involving c-Jun NH2-terminal Kinases and Activator Protein-1

  Xiaoyan Hui;Huiying Li;Zhiguang Zhou;Karen S.L. Lam

  213
  Citations

• Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia.

  Christopher P. Guise;Alexandra M. Mowday;Amir Ashoorzadeh;Ran Yuan

  210
  Citations

• Small molecule inhibitors of mdm2 and uses thereof

  Shaomeng Wang;Ke Ding;Yipin Lu;Zaneta Nikolovska-Coleska

  193
  Citations

• Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein

  Huimin Cheng;Junting Wan;Meng-I Lin;Yingxue Liu

  175
  Citations

• Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells.

  Jing-Xuan Pan;Ke Ding;Cheng-Yan Wang

  161
  Citations

• Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors.

  Mingshan Gao;Lei Duan;Jinfeng Luo;Lianwen Zhang

  158
  Citations

• Targeting EGFRL858R/T790M and EGFRL858R/T790M/C797S resistance mutations in NSCLC: Current developments in medicinal chemistry.

  Xiaoyun Lu;Lei Yu;Zhang Zhang;Xiaomei Ren

  154
  Citations

• New Promise and Opportunities for Allosteric Kinase Inhibitors

  Xiaoyun Lu;Jeff B. Smaill;Ke Ding

  151
  Citations

• (2-Pyridyl)acetone-promoted Cu-catalyzed O-arylation of phenols with aryl iodides, bromides, and chlorides.

  Qi Zhang;Deping Wang;Deping Wang;Xianyang Wang;Ke Ding

  151
  Citations

• 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells

  Nan Ma;Jun Hu;Zhi-Min Zhang;Wenyan Liu

  151
  Citations

• A CuAAC/Ullmann C-C coupling tandem reaction: copper-catalyzed reactions of organic azides with N-(2-iodoaryl)propiolamides or 2-iodo-N-(prop-2-ynyl)benzenamines.

  Qian Cai;Jiajie Yan;Ke Ding

  144
  Citations

• Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine790 → Methionine790 Mutant

  Shaohua Chang;Lianwen Zhang;Lianwen Zhang;Shilin Xu;Jinfeng Luo

  142
  Citations

• An Efficient Copper-Catalyzed Amination of Aryl Halides by Aqueous Ammonia

  Deping Wang;Deping Wang;Qian Cai;Ke Ding

  133
  Citations

• Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents

  Jian Tang;Bangxing Wang;Tian Wu;Junting Wan

  114
  Citations