World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
19117
World Ranking
6284
National Ranking
224

Research.com Recognitions

  • 2018 - Fellow of the Royal Society of Canada Academy of Science

Overview

Guy Sauvageau is affiliated with the University of Montreal in Canada. Their research primarily focuses on medicine, with significant contributions to biochemistry, genetics, and molecular biology. They have a substantial body of work in subfields such as molecular biology, hematology, oncology, genetics, and immunology.

The scientist's research topics revolve around key areas in hematology and oncology. These topics include:

  • Acute Myeloid Leukemia Research
  • Hematopoietic Stem Cell Transplantation
  • Protein Degradation and Inhibitors
  • Acute Lymphoblastic Leukemia research
  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Mesenchymal stem cell research

Guy Sauvageau has contributed numerous papers to various scientific journals. Notable recent publications include:

  • "Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes" (2021), published in Immunity
  • "High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML" (2020), published in Blood
  • "UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex" (2021), published in Cell stem cell
  • "HLF expression defines the human hematopoietic stem cell state" (2021), published in Blood
  • "Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells" (2022), published in Nature Cell Biology

The publication venues where Guy Sauvageau has frequently published include:

  • Blood
  • Transplantation and Cellular Therapy
  • Experimental Hematology
  • Blood Advances
  • bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators with whom Guy Sauvageau has co-authored multiple publications are:

  • Josée Hébert
  • Jalila Chagraoui
  • Sandra Cohen
  • Nadia M. Bambace
  • Imran Ahmad

In recognition of their contributions to science, Guy Sauvageau was named a Fellow of the Royal Society of Canada in 2018 by the Academy of Science.

Best Publications

  • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

    Julie Lessard;Guy Sauvageau

  • HOXB4-INDUCED EXPANSION OF ADULT HEMATOPOIETIC STEM CELLS EX VIVO

    Jennifer Antonchuk;Guy Sauvageau;R.Keith Humphries;R.Keith Humphries

  • Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer

    Martin Sauvageau;Guy Sauvageau

  • Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

    G Sauvageau;U Thorsteinsdottir;C J Eaves;H J Lawrence

  • Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

    Evert Kroon;Jana Krosl;Unnur Thorsteinsdottir;Soheyl Baban

  • Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

    G Sauvageau;P M Lansdorp;C J Eaves;D E Hogge

  • Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

    Iman Fares;Jalila Chagraoui;Yves Gareau;Stéphane Gingras

  • Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion.

    Unnur Thorsteinsdottir;Aline Mamo;Evert Kroon;Lori Jerome

  • Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.

    U Thorsteinsdottir;G Sauvageau;M R Hough;W Dragowska

  • Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.

    H. Jeffrey Lawrence;H. Jeffrey Lawrence;H. Jeffrey Lawrence;Cheryl D. Helgason;Cheryl D. Helgason;Cheryl D. Helgason;Guy Sauvageau;Guy Sauvageau;Guy Sauvageau;Stephen Fong;Stephen Fong;Stephen Fong

  • In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein.

    Jana Krosl;Pamela Austin;Nathalie Beslu;Evert Kroon

  • HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation

    Jennifer Antonchuk;Guy Sauvageau;R.Keith Humphries;R.Keith Humphries

  • Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia.

    Unnur Thorsteinsdottir;Evert Kroon;Lori Jerome;Francesco Blasi

  • The Role of HOX Homeobox Genes in Normal and Leukemic Hematopoiesis

    H. Jeffrey Lawrence;Guy Sauvageau;R. Keith Humphries;Corey Largman

  • A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia.

    Camille Simon;Jalila Chagraoui;Jana Krosl;Patrick Gendron

  • Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation

    J Lessard;A Schumacher;U Thorsteinsdottir;M van Lohuizen

  • NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice

    Evert Kroon;Unnur Thorsteinsdottir;Nadine Mayotte;Takuro Nakamura

  • Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

    H. Jeffrey Lawrence;Julie Christensen;Stephen Fong;Yu-Long Hu

  • In vitro and in vivo expansion of hematopoietic stem cells

    Guy Sauvageau;Norman N Iscove;R Keith Humphries;R Keith Humphries

  • Enhanced In Vivo Regenerative Potential of HOXB4-Transduced Hematopoietic Stem Cells With Regulation of Their Pool Size

    Unnur Thorsteinsdottir;Unnur Thorsteinsdottir;Guy Sauvageau;Guy Sauvageau;R. Keith Humphries;R. Keith Humphries

Frequent Co-Authors

R. Keith Humphries
R. Keith Humphries University of British Columbia
Claude Perreault
Claude Perreault University of Montreal
Sylvain Meloche
Sylvain Meloche University of Montreal
Pierre Thibault
Pierre Thibault University of Montreal
Peter W. Zandstra
Peter W. Zandstra University of British Columbia
Connie J. Eaves
Connie J. Eaves University of British Columbia
Corey Largman
Corey Largman University of California, San Francisco
Philippe P. Roux
Philippe P. Roux University of Montreal
Norman N. Iscove
Norman N. Iscove University of Toronto
Hans Peter Kiem
Hans Peter Kiem Fred Hutchinson Cancer Research Center

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