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Norman N. Iscove

Norman N. Iscove

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
14072
World Ranking
14258
National Ranking
497

Overview

Norman N. Iscove is affiliated with the University of Toronto in Canada. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with a particular emphasis on molecular biology and biomedical engineering. Their work also intersects with cancer research and immunology, reflecting a multidisciplinary approach to understanding complex biological systems.

The scientist's research topics cover an array of specialized areas including single-cell and spatial transcriptomics, microfluidic and bio-sensing technologies, cancer genomics and diagnostics, epigenetics and DNA methylation, immune cell function and interaction, as well as RNA modifications related to cancer. These topics highlight a focus on advanced molecular techniques and their applications in disease and cellular function.

Norman N. Iscove has contributed to several publications, with recent papers listed as follows:

  • Microdroplet-based one-step RT-PCR for ultrahigh throughput single-cell multiplex gene expression analysis and rare cell detection, 2021, Scientific Reports
  • Realization of the T Lineage Program Involves GATA-3 Induction of Bcl11b and Repression of Cdkn2b Expression, 2022, The Journal of Immunology
  • Remembering James Till, 1931-2025, 2025, Experimental Hematology

These publications indicate engagement with both methodological development in gene expression analysis and immunological cellular programs, as well as contributions to the academic community through commemorative scholarly work.

Norman N. Iscove frequently collaborates with several researchers, reflecting connections across related domains. Frequent coauthors include:

  • Jennifer Ma
  • Gary Tran
  • Alwin M. D. Wan
  • Edmond W. K. Young
  • Eugenia Kumacheva

The majority of their work is published in journals such as Scientific Reports, The Journal of Immunology, and Experimental Hematology. These venues align with their research interests in molecular biology and immunology.

Best Publications

  • Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

    Wen-Chen Yeh;Arda Shahinian;Daniel I Speiser;Janine Kraunus

  • CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

    Junko Irie-Sasaki;Junko Irie-Sasaki;Takehiko Sasaki;Takehiko Sasaki;Wataru Matsumoto;Anne Opavsky

  • Colony Formation by Normal and Leukemic Human Marrow Cells in Culture: Effect of Conditioned Medium From Human Leukocytes

    N. N. Iscove;N. N. Iscove;J. S. Senn;J. S. Senn;J. E. Till;E. A. Mcculloch

  • Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

    Iman Fares;Jalila Chagraoui;Yves Gareau;Stéphane Gingras

  • Self-renewal as a therapeutic target in human colorectal cancer

    Antonija Kreso;Peter van Galen;Nicholas M Pedley;Evelyne Lima-Fernandes

  • Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations

    Cindi M. Morshead;Patricia Benveniste;Norman N. Iscove;Derek van der Kooy

  • Transcriptome analysis of the normal human mammary cell commitment and differentiation process.

    Afshin Raouf;Yun Zhao;Karen To;John Stingl

  • MLK-3 ACTIVATES THE SAPK/JNK AND P38/RK PATHWAYS VIA SEK1 AND MKK3/6

    L. A. Tibbles;Y. L. Ing;F. Kiefer;J. Chan

  • Representation is faithfully preserved in global cDNA amplified exponentially from sub-picogram quantities of mRNA

    Norman N Iscove;Norman N Iscove;Mary Barbara;Mary Barbara;Marie Gu;Marie Gu;Meredith Gibson

  • Bipotential precursors of B cells and macrophages in murine fetal liver.

    Ana Cumano;Christopher J. Paige;Norman N. Iscove;Gerard Brady

  • HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.

    F Kiefer;L A Tibbles;M Anafi;A Janssen

  • CDK6 levels regulate quiescence exit in human hematopoietic stem cells.

    Elisa Laurenti;Catherine Frelin;Stephanie Xie;Robin Ferrari;Robin Ferrari

  • Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion

    Norman N. Iscove;Katsuhiko Nawa

  • Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential

    Patricia Benveniste;Catherine Frelin;Catherine Frelin;Salima Janmohamed;Salima Janmohamed;Mary Barbara;Mary Barbara

  • In vitro and in vivo expansion of hematopoietic stem cells

    Guy Sauvageau;Norman N Iscove;R Keith Humphries;R Keith Humphries

  • Retinoic Acid Signaling Is Essential for Embryonic Hematopoietic Stem Cell Development

    Bhaskar Chanda;Andrea Ditadi;Norman N. Iscove;Norman N. Iscove;Gordon Keller;Gordon Keller

  • Representative in Vitro cDNA Amplification From Individual Hemopoietic Cells and Colonies

    Gerard Brady;Mary Barbara;Norman N. Iscove

  • Decreased UDP‐GlcNAc levels abrogate proliferation control in EMeg32‐deficient cells

    Guido Boehmelt;Andrew Wakeham;Andrew Elia;Takehiko Sasaki

  • Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells

    Gerard Brady;Filio Billia;Jennifer Knox;Trang Hoang

  • Representation is faithfully preserved in global cDNA amplified exponentially from

    Norman N. Iscove;Mary Barbara;Marie Gu;Meredith Gibson

Frequent Co-Authors

Christopher J. Paige
Christopher J. Paige Princess Margaret Cancer Centre
Guy Sauvageau
Guy Sauvageau University of Montreal
Friedemann Kiefer
Friedemann Kiefer University of Münster
Gordon Keller
Gordon Keller University of Toronto
John E. Dick
John E. Dick Princess Margaret Cancer Centre
Tony Pawson
Tony Pawson University of Toronto
Juan Carlos Zúñiga-Pflücker
Juan Carlos Zúñiga-Pflücker University of Toronto
R. Keith Humphries
R. Keith Humphries University of British Columbia
Connie J. Eaves
Connie J. Eaves University of British Columbia
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre

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