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Sylvain Meloche

Sylvain Meloche

D-Index & Metrics

Molecular Biology

D-Index
66
Citations
16127
World Ranking
1616
National Ranking
47

Overview

Sylvain Meloche is affiliated with the University of Montreal in Canada and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their research spans a range of subfields including Molecular Biology, Oncology, Cell Biology, Pathology and Forensic Medicine, and Immunology.

The primary focus areas in Meloche's work include multiple specific topics such as:

  • Melanoma and MAPK Pathways
  • Genetics, Aging, and Longevity in Model Organisms
  • Ubiquitin and proteasome pathways
  • Hippo pathway signaling and YAP/TAZ
  • Protein Kinase Regulation and GTPase Signaling
  • Cell Adhesion Molecules Research
  • Cancer-related Molecular Pathways

Meloche's notable recent publications reflect diverse research interests and appear in several recognized scientific venues. Selected papers include:

  • Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer, 2020, Nature Communications
  • Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential, 2021, Pharmacological Reviews
  • CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma, 2022, Nature Communications
  • Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis, 2020, Oncogene
  • Interleukin-17 Receptor D in Physiology, Inflammation and Cancer, 2021, Frontiers in Oncology

Frequently publishing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Journal of Cellular Physiology, Oncogene, and Frontiers in Oncology, Meloche has established a consistent presence across several prominent platforms.

Their collaborative research includes frequent partnerships with the following coauthors:

  • Marc K. Saba-El-Leil
  • Mathilde Soulez
  • Laure Voisin
  • Pierre-Luc Tanguay
  • Alexey Kotlyarov

This collaborative network supports a body of work integrating molecular mechanisms underlying cancer, cell signaling pathways, and protein regulation. Meloche's research contributions are characterized by a strong emphasis on the molecular basis of disease, particularly cancer biology and signaling networks influencing cellular behavior.

Best Publications

  • The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

    S Meloche;J Pouysségur

  • Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

    Gille Pages;Philippe Lenormand;Gilles L'Allemain;Jean-Claude Chambard

  • FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment

    Tilo Kunath;Marc K. Saba-El-Leil;Marwa Almousailleakh;Jason Wray

  • An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.

    Marc K Saba‐El‐Leil;Francis D J Vella;Bertrand Vernay;Laure Voisin

  • Roles of the Candida albicans Mitogen-Activated Protein Kinase Homolog, Cek1p, in Hyphal Development and Systemic Candidiasis

    Csilla Csank;Csilla Csank;Klaus Schröppel;Ekkehard Leberer;Doreen Harcus

  • Atypical mitogen-activated protein kinases: Structure, regulation and functions

    Phillipe Coulombe;Sylvain Meloche

  • Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.

    S Meloche;K Seuwen;G Pagès;J Pouysségur

  • p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

    Geneviève Rodier;Alessia Montagnoli;Lucia Di Marcotullio;Philippe Coulombe

  • Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis.

    Lily Yen;Xiao-Li You;Ala-Eddin Al Moustafa;Gerald Batist

  • Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA.

    Frédéric Charron;George Tsimiklis;Mathieu Arcand;Lynda Robitaille

  • MEK1-ERK2 Signaling Pathway Protects Myocardium From Ischemic Injury In Vivo

    Daniel J. Lips;Orlando F. Bueno;Benjamin J. Wilkins;Nicole H. Purcell

  • From basic research to clinical development of MEK1/2 inhibitors for cancer therapy

    Christophe Frémin;Sylvain Meloche

  • Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo

    Nicole H. Purcell;Benjamin J. Wilkins;Allen York;Marc K. Saba-El-Leil

  • Extracellular Signal-Regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth

    Izhak Kehat;Jennifer Davis;Malte Tiburcy;Federica Accornero

  • Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.

    Rongtuan Lin;P. Beauparlant;C. Makris;S. Meloche

  • Inhibition of Growth Factor-induced Protein Synthesis by a Selective MEK Inhibitor in Aortic Smooth Muscle Cells

    Marc J. Servant;Edith Giasson;Sylvain Meloche

  • An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

    Derek F. Ceccarelli;Xiaojing Tang;Benoit Pelletier;Stephen Orlicky

  • ERKs in Cancer: Friends or Foes?

    Xavier Deschênes-Simard;Filippos Kottakis;Sylvain Meloche;Gerardo Ferbeyre

  • The IKK-related kinases: from innate immunity to oncogenesis.

    Jean-François Clément;Sylvain Meloche;Marc J Servant

  • Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.

    Léo Aubert;Neethi Nandagopal;Zachary Steinhart;Geneviève Lavoie

Frequent Co-Authors

Guy Sauvageau
Guy Sauvageau University of Montreal
Pierre Thibault
Pierre Thibault University of Montreal
Malcolm Whiteway
Malcolm Whiteway Concordia University
David Y. Thomas
David Y. Thomas McGill University
Jeffery D. Molkentin
Jeffery D. Molkentin Cincinnati Children's Hospital Medical Center
Matthias Trost
Matthias Trost Newcastle University
Mike Tyers
Mike Tyers University of Montreal
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Katherine L. B. Borden
Katherine L. B. Borden Northwestern University
Rui Chen
Rui Chen Capital Medical University

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