What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Phosphorylation
His main research concerns Cell biology, MAPK/ERK pathway, Receptor tyrosine kinase, Molecular biology and Biochemistry.
His research ties Transcription factor and Cell biology together.
His MAPK/ERK pathway research incorporates themes from Mitogen-activated protein kinase, Endocrinology, Embryonic stem cell and Internal medicine.
His Mitogen-activated protein kinase research is multidisciplinary, incorporating elements of MAPK7, MAPK14 and Sudden death.
His work deals with themes such as Paracrine signalling, Angiogenesis, Growth factor and Autocrine signalling, which intersect with Receptor tyrosine kinase.
Sylvain Meloche combines subjects such as PI3K/AKT/mTOR pathway, PTEN, MEK inhibitor and MAP2K7 with his study of Molecular biology.
His most cited work include:
- Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation (872 citations)
- The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition (827 citations)
- FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment (659 citations)
What are the main themes of his work throughout his whole career to date?
Sylvain Meloche mostly deals with Cell biology, Molecular biology, Internal medicine, Endocrinology and Kinase.
His Cell biology study frequently draws connections to adjacent fields such as Biochemistry.
In his study, which falls under the umbrella issue of Molecular biology, Carcinogenesis is strongly linked to Cell growth.
His Endocrinology study combines topics in areas such as Angiotensin II, Neonatal lethality and Pulmonary surfactant.
Sylvain Meloche has researched MAPK/ERK pathway in several fields, including Embryonic stem cell and Protein kinase A.
His Cyclin-dependent kinase 2 research is multidisciplinary, incorporating elements of MAP kinase kinase kinase and Mitogen-activated protein kinase kinase.
He most often published in these fields:
- Cell biology (46.67%)
- Molecular biology (21.48%)
- Internal medicine (21.48%)
What were the highlights of his more recent work (between 2012-2021)?
- Cell biology (46.67%)
- MAPK/ERK pathway (14.07%)
- Cancer research (12.59%)
In recent papers he was focusing on the following fields of study:
His primary areas of investigation include Cell biology, MAPK/ERK pathway, Cancer research, Kinase and Protein kinase A.
His is doing research in Signal transduction and Phosphorylation, both of which are found in Cell biology.
His biological study spans a wide range of topics, including Cell cycle checkpoint, Cell signaling, Protein degradation, Senescence and Effector.
The concepts of his Cancer research study are interwoven with issues in Proto-Oncogene Proteins B-raf, mTORC1, Leukemia and Kinase activity.
His Kinase research is multidisciplinary, relying on both Cell culture, Chromone, Stereochemistry and Allosteric regulation.
His research integrates issues of Lead compound, MyoD, Molecular model and Myocyte in his study of Protein kinase A.
Between 2012 and 2021, his most popular works were:
- Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation (111 citations)
- The transcriptomic landscape and directed chemical interrogation of MLL -rearranged acute myeloid leukemias (94 citations)
- Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions (94 citations)
In his most recent research, the most cited papers focused on:
His primary scientific interests are in Cell biology, MAPK/ERK pathway, Cancer research, Cell signaling and Signal transduction.
His Cell biology study frequently involves adjacent topics like Telomere.
He interconnects mTORC1, Eukaryotic initiation factor 4F, Translation initiation complex and Protein kinase A in the investigation of issues within MAPK/ERK pathway.
His Cancer research research is multidisciplinary, incorporating perspectives in Mutation, Gene, Leukemia and PI3K/AKT/mTOR pathway.
The study incorporates disciplines such as Cell cycle checkpoint, Transcriptional regulation, Phosphorylation, Chromatin remodeling and Phosphoproteomics in addition to Cell signaling.
His Signal transduction research includes elements of Embryonic stem cell, Regulation of gene expression, Transgene and Effector.
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