His main research concerns Cell biology, MAPK/ERK pathway, Receptor tyrosine kinase, Molecular biology and Biochemistry. His research ties Transcription factor and Cell biology together. His MAPK/ERK pathway research incorporates themes from Mitogen-activated protein kinase, Endocrinology, Embryonic stem cell and Internal medicine.
His Mitogen-activated protein kinase research is multidisciplinary, incorporating elements of MAPK7, MAPK14 and Sudden death. His work deals with themes such as Paracrine signalling, Angiogenesis, Growth factor and Autocrine signalling, which intersect with Receptor tyrosine kinase. Sylvain Meloche combines subjects such as PI3K/AKT/mTOR pathway, PTEN, MEK inhibitor and MAP2K7 with his study of Molecular biology.
Sylvain Meloche mostly deals with Cell biology, Molecular biology, Internal medicine, Endocrinology and Kinase. His Cell biology study frequently draws connections to adjacent fields such as Biochemistry. In his study, which falls under the umbrella issue of Molecular biology, Carcinogenesis is strongly linked to Cell growth.
His Endocrinology study combines topics in areas such as Angiotensin II, Neonatal lethality and Pulmonary surfactant. Sylvain Meloche has researched MAPK/ERK pathway in several fields, including Embryonic stem cell and Protein kinase A. His Cyclin-dependent kinase 2 research is multidisciplinary, incorporating elements of MAP kinase kinase kinase and Mitogen-activated protein kinase kinase.
His primary areas of investigation include Cell biology, MAPK/ERK pathway, Cancer research, Kinase and Protein kinase A. His is doing research in Signal transduction and Phosphorylation, both of which are found in Cell biology. His biological study spans a wide range of topics, including Cell cycle checkpoint, Cell signaling, Protein degradation, Senescence and Effector.
The concepts of his Cancer research study are interwoven with issues in Proto-Oncogene Proteins B-raf, mTORC1, Leukemia and Kinase activity. His Kinase research is multidisciplinary, relying on both Cell culture, Chromone, Stereochemistry and Allosteric regulation. His research integrates issues of Lead compound, MyoD, Molecular model and Myocyte in his study of Protein kinase A.
His primary scientific interests are in Cell biology, MAPK/ERK pathway, Cancer research, Cell signaling and Signal transduction. His Cell biology study frequently involves adjacent topics like Telomere. He interconnects mTORC1, Eukaryotic initiation factor 4F, Translation initiation complex and Protein kinase A in the investigation of issues within MAPK/ERK pathway.
His Cancer research research is multidisciplinary, incorporating perspectives in Mutation, Gene, Leukemia and PI3K/AKT/mTOR pathway. The study incorporates disciplines such as Cell cycle checkpoint, Transcriptional regulation, Phosphorylation, Chromatin remodeling and Phosphoproteomics in addition to Cell signaling. His Signal transduction research includes elements of Embryonic stem cell, Regulation of gene expression, Transgene and Effector.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
Gille Pages;Philippe Lenormand;Gilles L'Allemain;Jean-Claude Chambard.
Proceedings of the National Academy of Sciences of the United States of America (1993)
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition
S Meloche;J Pouysségur.
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
Tilo Kunath;Marc K. Saba-El-Leil;Marwa Almousailleakh;Jason Wray.
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.
Marc K Saba‐El‐Leil;Francis D J Vella;Bertrand Vernay;Laure Voisin.
EMBO Reports (2003)
Roles of the Candida albicans Mitogen-Activated Protein Kinase Homolog, Cek1p, in Hyphal Development and Systemic Candidiasis
Csilla Csank;Csilla Csank;Klaus Schröppel;Ekkehard Leberer;Doreen Harcus.
Infection and Immunity (1998)
Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.
S Meloche;K Seuwen;G Pagès;J Pouysségur.
Molecular Endocrinology (1992)
Atypical mitogen-activated protein kinases: Structure, regulation and functions
Phillipe Coulombe;Sylvain Meloche.
Biochimica et Biophysica Acta (2007)
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
Geneviève Rodier;Alessia Montagnoli;Lucia Di Marcotullio;Philippe Coulombe.
The EMBO Journal (2001)
Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA.
Frédéric Charron;George Tsimiklis;Mathieu Arcand;Lynda Robitaille.
Genes & Development (2001)
Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis.
Lily Yen;Xiao-Li You;Ala-Eddin Al Moustafa;Gerald Batist.
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: