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Genetics

D-Index
80
Citations
24964
World Ranking
1578
National Ranking
37

Overview

Rui Chen is affiliated with Capital Medical University in China and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with a particular focus on medicine. Their research portfolio includes 223 publications in the main field of biochemistry, genetics and molecular biology, and 97 in medicine. Subfields of study include molecular biology, ophthalmology, genetics, immunology, and radiology, nuclear medicine and imaging.

The researcher's work covers several main topics:

  • Retinal Development and Disorders
  • Single-cell and spatial transcriptomics
  • Retinal Diseases and Treatments
  • CRISPR and Genetic Engineering
  • Genomics and Rare Diseases
  • Cell Image Analysis Techniques
  • Glaucoma and retinal disorders

Rui Chen has published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory) with 30 publications, followed by Nature Communications (7), Investigative Ophthalmology & Visual Science (6), Human Molecular Genetics (5), and Genetics in Medicine (4).

Recent significant papers include:

  • Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue (2020) in Circulation
  • DeepST: identifying spatial domains in spatial transcriptomics by deep learning (2022) in Nucleic Acids Research
  • Enhanced genome assembly and a new official gene set for Tribolium castaneum (2020) in BMC Genomics
  • Mapping the cis-regulatory architecture of the human retina reveals noncoding genetic variation in disease (2020) in Proceedings of the National Academy of Sciences
  • Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea (2020) in The Ocular Surface

Frequent co-authors in Rui Chen's research include:

  • Yumei Li
  • Qingnan Liang
  • Xuesen Cheng
  • Ala Moshiri
  • Jongsu Choi

Best Publications

  • Genome sequence of the Brown Norway rat yields insights into mammalian evolution

    Richard A. Gibbs;George M. Weinstock;Michael L. Metzker;Donna M. Muzny

  • Evolutionary and biomedical insights from the rhesus macaque genome

    Richard A. Gibbs;Jeffrey Rogers

  • The DNA sequence of the human X chromosome

    Mark T Ross;Darren V Grafham;Alison J Coffey;Steven Scherer

  • Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

    Deqiang Sun;Min Luo;Mira Jeong;Benjamin Rodriguez

  • TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.

    Rafael Bejar;Allegra Lord;Kristen Stevenson;Michal Bar-Natan

  • Comparative genome sequencing of Drosophila pseudoobscura: Chromosomal, gene, and cis-element evolution

    Stephen Richards;Yue Liu;Brian R. Bettencourt;Pavel Hradecky

  • Analysis of the Human Endogenous Coregulator Complexome

    Anna Malovannaya;Rainer B. Lanz;Sung Yun Jung;Yaroslava Bulynko

  • optix Drives the Repeated Convergent Evolution of Butterfly Wing Pattern Mimicry

    Robert D. Reed;Riccardo Papa;Riccardo Papa;Arnaud Martin;Heather M. Hines

  • Dachshund and Eyes Absent Proteins Form a Complex and Function Synergistically to Induce Ectopic Eye Development in Drosophila

    Rui Chen;Mehran Amoui;Zhihuan Zhang;Graeme Mardon

  • Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

    Moumita Chaki;Rannar Airik;Amiya K. Ghosh;Rachel H. Giles

  • A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases

    Shinya Yamamoto;Manish Jaiswal;Wu Lin Charng;Tomasz Gambin

  • Performance comparison of whole-genome sequencing platforms

    Hugo Y K Lam;Michael J Clark;Rui Chen;Rong Chen

  • Large conserved domains of low DNA methylation maintained by Dnmt3a.

    Mira Jeong;Deqiang Sun;Min Luo;Yun Huang

  • Direct Regulation of GTP Homeostasis by (p)ppGpp: A Critical Component of Viability and Stress Resistance

    Allison Kriel;Alycia N. Bittner;Sok Ho Kim;Kuanqing Liu

  • High-Precision, Whole-Genome Sequencing of Laboratory Strains Facilitates Genetic Studies

    Anjana Srivatsan;Yi Han;Jianlan Peng;Ashley K. Tehranchi

  • Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements

    Feng Wang;Hui Wang;Han Fang Tuan;Duy H. Nguyen

  • Hemichordate genomes and deuterostome origins

    Oleg Simakov;Takeshi Kawashima;Ferdinand Marlétaz;Jerry Jenkins

  • Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.

    Shengping Hou;Zhenglin Yang;Liping Du;Zhengxuan Jiang

  • An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

    Charles E. Ogburn;Junko Oshima;Martin Poot;Ru Chen

  • A proteomic landscape of diffuse-type gastric cancer

    Sai Ge;Xia Xia;Chen Ding;Chen Ding;Bei Zhen

Frequent Co-Authors

Hui Wang
Hui Wang Salk Institute for Biological Studies
Graeme Mardon
Graeme Mardon Baylor College of Medicine
Michael Snyder
Michael Snyder Stanford University
Robert K. Koenekoop
Robert K. Koenekoop McGill University Health Centre
Richard A. Gibbs
Richard A. Gibbs Baylor College of Medicine
Charles Wang Wai Ng
Charles Wang Wai Ng Hong Kong University of Science and Technology
Haiqiao Wei
Haiqiao Wei Tianjin University
Stephen P. Daiger
Stephen P. Daiger The University of Texas Health Science Center at Houston
David G. Birch
David G. Birch The University of Texas Southwestern Medical Center
Hao Sun
Hao Sun Chinese University of Hong Kong

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