2026 Philippe Leboulch: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	56	2183	1965	1083	960	166	18057

Overview

Philippe Leboulch is affiliated with Brigham and Women's Hospital in the United States. Their research focuses primarily on Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to the fields of Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health, Infectious Diseases, and Hematology.

The scientist's main research topics include:

Hemoglobinopathies and Related Disorders
Prenatal Screening and Diagnostics
Parvovirus B19 Infection Studies
Virus-based gene therapy research
Iron Metabolism and Disorders
Pluripotent Stem Cells Research
Liver physiology and pathology

Leboulch has published in various journals and scientific venues, notably including:

Nature Medicine
American Journal of Hematology
Molecular Therapy
International Journal of Molecular Sciences
Cytotherapy

Recent publications demonstrate a focus on gene therapy and hematologic diseases. Selected recent papers include:

"Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: the HGB-205 trial" (2022, Nature Medicine)
"Lovo-cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB-206 study" (2022, American Journal of Hematology)
"Coordinated β-globin expression and α2-globin reduction in a multiplex lentiviral gene therapy vector for β-thalassemia" (2021, Molecular Therapy)
"Successful Derivation of Hepatoblasts, Cholangiocytes and Hepatocytes from Simian Induced Pluripotent Stem Cells" (2022, International Journal of Molecular Sciences)
"Droplet digital polymerase chain reaction-based quantitation of therapeutic lentiviral vector copies in transduced hematopoietic stem cells" (2024, Cytotherapy)

The scientist frequently collaborates with the following researchers:

Emmanuel Payen (3 joint publications)
Mohammed Asmal (2 joint publications)
Manfred Schmidt (2 joint publications)
Jean-Antoine Ribeil (2 joint publications)
Suradej Hongeng (2 joint publications)

Best Publications

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

S. Hacein-Bey-Abina;C. Von Kalle;C. Von Kalle;M. Schmidt;M. P. McCormack

4518
Citations
Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

Nathalie Cartier;Salima Hacein-Bey-Abina;Cynthia C. Bartholomae;Gabor Veres

1787
Citations
Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

Marina Cavazzana-Calvo;Emmanuel Payen;Olivier Negre;Gary Wang

1620
Citations
Gene Therapy in a Patient with Sickle Cell Disease.

Jean-Antoine Ribeil;Salima Hacein-Bey-Abina;Emmanuel Payen;Alessandra Magnani

744
Citations
Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia

Alexis A. Thompson;Mark C. Walters;Janet Kwiatkowski;John E.J. Rasko;John E.J. Rasko;John E.J. Rasko

709
Citations
Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy

Robert Pawliuk;Karen A. Westerman;Mary E. Fabry;Emmanuel Payen

704
Citations
Heme-regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

An-Ping Han;Channing Yu;Linrong Lu;Yuko Fujiwara

467
Citations
Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

Igor B. Rosenwald;Roger Kaspar;Dennis Rousseau;Lee Gehrke

338
Citations
Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists.

Stéphane Prost;Francis Relouzat;Marc Spentchian;Yasmine Ouzegdouh

323
Citations
Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange.

Yong Qing Feng;Jost Seibler;Raouf Alami;Andrew Eisen

286
Citations
Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination

Karen A. Westerman;Philippe Leboulch

270
Citations
Placenta Growth Factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers

Anna Eriksson;Renhai Cao;Robert Pawliuk;Sanna Maria Berg

248
Citations
Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure

P. Leboulch;G. M. S. Huang;R. K. Humphries;Y. H. Oh

231
Citations
A phase I/II clinical trial of β-globin gene therapy for β-thalassemia

Arthur Bank;Ronald Dorazio;Philippe Leboulch

230
Citations
Permanent and panerythroid correction of murine β thalassemia by multiple lentiviral integration in hematopoietic stem cells

Suzan Imren;Emmanuel Payen;Karen A. Westerman;Robert Pawliuk

225
Citations
A human β-cell line for transplantation therapy to control type 1 diabetes

Michiki Narushima;Naoya Kobayashi;Teru Okitsu;Yoshihito Tanaka

205
Citations
Transcriptional Behavior of LCR Enhancer Elements Integrated at the Same Chromosomal Locus by Recombinase-Mediated Cassette Exchange

Eric E. Bouhassira;Karen Westerman;Karen Westerman;Karen Westerman;Philippe Leboulch;Philippe Leboulch;Philippe Leboulch

203
Citations
Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the βA(T87Q)-Globin Gene

Olivier Negre;Anne-Virginie Eggimann;Yves Beuzard;Jean-Antoine Ribeil

182
Citations
High-level β-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells

Suzan Imren;Mary E. Fabry;Karen A. Westerman;Robert Pawliuk

173
Citations
Erosion Of The Chronic Myeloid Leukemia Stem Cell Pool By PPARγ Agonists

Francis Relouzat;Marc Spenchian;Gérald Massonnet;Jean-Paul Beressi

0
Citations

Frequent Co-Authors

Noriaki Tanaka Okayama University

Yves Beuzard University of Paris-Saclay

Toshiyoshi Fujiwara Okayama University

John E.J. Rasko Centenary Institute of Cancer Medicine and Cell Biology

Marina Cavazzana-Calvo Necker-Enfants Malades Hospital

Connie J. Eaves University of British Columbia

Christof von Kalle Charité - University Medicine Berlin

Masakiyo Sakaguchi Okayama University

Alain Fischer Collège de France

Suthat Fucharoen Mahidol University

External Links

Personal website of Philippe Leboulch

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