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Molecular Biology

D-Index
60
Citations
14331
World Ranking
1948
National Ranking
12

Overview

Heinrich Kovar is affiliated with St Anna Children's Hospital in Austria and focuses on research in the fields of biochemistry, genetics, molecular biology, and medicine. Their work spans multiple subfields, including molecular biology, pulmonary and respiratory medicine, neurology, cancer research, and oncology.

The scientist's research topics cover a range of areas, notably:

  • Sarcoma Diagnosis and Treatment
  • Neuroblastoma Research and Treatments
  • Protein Degradation and Inhibitors
  • Hippo pathway signaling and YAP/TAZ
  • Cancer Genomics and Diagnostics
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer

Among recent papers authored or coauthored by Heinrich Kovar are the following:

  • The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma Pathogenesis, 2020, published in Cells
  • Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives, 2021, Journal of Clinical Medicine
  • Mechanisms, Diagnosis and Treatment of Bone Metastases, 2021, Cells
  • YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells, 2021, Oncogenesis
  • An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma, 2022, npj Precision Oncology

Heinrich Kovar has published most frequently in venues such as:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cells
  • Journal of Clinical Medicine
  • Oncogenesis

The scientist frequently collaborates with other researchers including Florian Halbritter, Didier Surdez, Branka Radic-Sarikas, Martin Distel, and Thomas G. P. Grünewald. These recurrent coauthor relationships show significant teamwork in various related biomedical fields.

Best Publications

  • Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

    Olivier Delattre;Jessica Zucman;Béatrice Plougastel;Chantal Desmaze

  • MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration.

    Inge M. Ambros;Peter F. Ambros;Sabine Strehl;Heinrich Kovar

  • Ewing Sarcoma: Current Management and Future Approaches Through Collaboration

    Nathalie Gaspar;Douglas S. Hawkins;Uta Dirksen;Ian J. Lewis

  • Ewing’s Sarcoma Family of Tumors: Current Management

    Mark Bernstein;Heinrich Kovar;Michael Paulussen;R Randall

  • Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor Patients

    A Zoubek;B Dockhorn-Dworniczak;O Delattre;H Christiansen

  • EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

    Günther H. S. Richter;Stephanie Plehm;Annette Fasan;Sabine Rössler

  • Impact of EWS-ETS Fusion Type on Disease Progression in Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor: Prospective Results From the Cooperative Euro-E.W.I.N.G. 99 Trial

    Marie-Cecile Le Deley;Olivier Delattre;Karl-Ludwig Schaefer;Sue A. Burchill

  • DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma

    Nathan C. Sheffield;Gaelle Pierron;Johanna Klughammer;Paul Datlinger

  • A Molecular Function Map of Ewing's Sarcoma

    Maximilian Kauer;Jozef Ban;Reinhard Kofler;Bob Walker

  • Overexpression of the pseudoautosomal gene MIC2 in Ewing's sarcoma and peripheral primitive neuroectodermal tumor.

    H Kovar;M Dworzak;S Strehl;E Schnell

  • Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

    Eleni M. Tomazou;Nathan C. Sheffield;Christian Schmidl;Michael Schuster

  • EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro.

    H. Kovar;D. N. T. Aryee;G. Jug;C. Henöckl

  • Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine

    Peter Valent;Bernd Groner;Udo Schumacher;Giulio Superti-Furga

  • EWS-FLI1 and EWS-ERG Gene Fusions Are Associated With Similar Clinical Phenotypes in Ewing's Sarcoma

    Jill P. Ginsberg;Enrique de Alava;Marc Ladanyi;Leonard H. Wexler

  • Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma

    Sophie Postel-Vinay;Amélie S Véron;Franck Tirode;Gaelle Pierron

  • Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II

    Robert Petermann;Birgit M Mossier;Dave Nt Aryee;Vladimir Khazak

  • Caveolin-1 (CAV1) Is a Target of EWS/FLI-1 and a Key Determinant of the Oncogenic Phenotype and Tumorigenicity of Ewing's Sarcoma Cells

    Oscar M. Tirado;Silvia Mateo-Lozano;Joaquín Villar;Luis E. Dettin

  • Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors

    Heinrich Kovar;Gunhild Jug;Dave Nt Aryee;Andreas Zoubek

  • Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives.

    Stefan K. Zöllner;Stefan K. Zöllner;James F. Amatruda;Sebastian Bauer;Sebastian Bauer;Stéphane Collaud;Stéphane Collaud

  • Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family

    Heinrich Kovar

Frequent Co-Authors

Helmut Gadner
Helmut Gadner St Anna Children's Hospital
Peter F. Ambros
Peter F. Ambros St Anna Children's Hospital
Olivier Delattre
Olivier Delattre PSL University
Paul S. Meltzer
Paul S. Meltzer National Institutes of Health
Katia Scotlandi
Katia Scotlandi Wayne State University
Piero Picci
Piero Picci University of Bologna
Richard Moriggl
Richard Moriggl University of Veterinary Medicine Vienna
Jeffrey A. Toretsky
Jeffrey A. Toretsky Georgetown University
Thomas Lion
Thomas Lion Medical University of Vienna
Christoph Bock
Christoph Bock Austrian Academy of Sciences

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