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Jeffrey A. Toretsky

Jeffrey A. Toretsky

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
11150
World Ranking
15574
National Ranking
6494

Research.com Recognitions

  • 2017 - Fellow, National Academy of Inventors

Overview

Jeffrey A. Toretsky is affiliated with Georgetown University in the United States and has a research focus primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans multiple disciplines with a strong emphasis on molecular biology, pulmonary and respiratory medicine, genetics, immunology, and cancer research.

The scientist's research topics include:

  • Sarcoma Diagnosis and Treatment
  • RNA modifications and cancer
  • Protein Degradation and Inhibitors
  • RNA Research and Splicing
  • Extracellular vesicles in disease
  • Interferon and immune responses
  • RNA regulation and disease

Jeffrey A. Toretsky has contributed to various scientific journals with publications in venues such as:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Advanced Science
  • Journal of Clinical Oncology
  • Advanced Functional Materials

Selected recent papers include:

  • "Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives," 2021, Journal of Clinical Medicine
  • O-Linked-N-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics, 2021, Journal of the American Chemical Society
  • "Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response," 2021, Cancer Research
  • "Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations," 2022, Advanced Science
  • "An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma," 2022, npj Precision Oncology

Frequent coauthors collaborating with Jeffrey A. Toretsky include:

  • Aykut Üren
  • Noah Federman
  • Saravana P. Selvanathan
  • Anna Molotkova
  • Emre Deniz

They have been recognized as a Fellow of the National Academy of Inventors since 2017.

Best Publications

  • Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

    David A. Solomon;Taeyeon Kim;Laura A. Diaz-Martinez;Joshlean Fair

  • BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.

    C.A. French;C.L. Ramirez;J. Kolmakova;T.T. Hickman

  • A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.

    Hayriye V Erkizan;Yali Kong;Melinda Merchant;Silke Schlottmann

  • Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90

    Mikhail V. Blagosklonny;Jeffrey Toretsky;Sean Bohen;Len Neckers

  • Midline Carcinoma of Children and Young Adults With NUT Rearrangement

    Christopher A. French;Jeffery L. Kutok;William C. Faquin;Jeffrey A. Toretsky

  • Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

    Elspeth M. Beauchamp;Lymor Ringer;Gülay Bulut;Kamal P. Sajwan

  • Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

    Weiying Zhang;Nivedita Nandakumar;Yuhao Shi;Mark Manzano

  • EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

    Aparna Gorthi;July Carolina Romero;Eva Loranc;Lin Cao

  • The genomic landscape of juvenile myelomonocytic leukemia.

    Elliot Stieglitz;Amaro N. Taylor-Weiner;Tiffany Y. Chang;Laura C. Gelston

  • The Insulin-like Growth Factor-I Receptor Is Required for EWS/FLI-1 Transformation of Fibroblasts

    Jeffrey A. Toretsky;Thea Kalebic;Vicki Blakesley;Derek LeRoith

  • Assemblages: Functional units formed by cellular phase separation

    Jeffrey A. Toretsky;Peter E. Wright

  • Geldanamycin selectively destabilizes and conformationally alters mutated p53.

    M V Blagosklonny;J Toretsky;L Neckers

  • Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression.

    Aykut Üren;Shannon Fallen;Hang Yuan;Alp Usubütün

  • Biology of childhood osteogenic sarcoma and potential targets for therapeutic development : Meeting summary

    Richard Gorlick;Peter Anderson;Irene Andrulis;Carola Arndt

  • Involvement of IGF-II in human cancer.

    J A Toretsky;L J Helman

  • GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein

    Elspeth Beauchamp;Gulay Bulut;Ogan D. Abaan;Kevin Chen

  • High ALDH Activity Identifies Chemotherapy-Resistant Ewing's Sarcoma Stem Cells That Retain Sensitivity to EWS-FLI1 Inhibition

    Ola Awad;Jason T. Yustein;Jason T. Yustein;Preeti Shah;Naheed Gul

  • Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives.

    Stefan K. Zöllner;Stefan K. Zöllner;James F. Amatruda;Sebastian Bauer;Sebastian Bauer;Stéphane Collaud;Stéphane Collaud

  • Oncoprotein EWS-FLI1 Activity Is Enhanced by RNA Helicase A

    Jeffrey A. Toretsky;Verda Erkizan;Amy Levenson;Ogan D. Abaan

  • Author Correction: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

    Aparna Gorthi;Aparna Gorthi;July Carolina Romero;July Carolina Romero;Eva Loranc;Lin Cao

Frequent Co-Authors

Lee J. Helman
Lee J. Helman Children's Hospital of Los Angeles
Heinrich Kovar
Heinrich Kovar St Anna Children's Hospital
Richard Moriggl
Richard Moriggl University of Veterinary Medicine Vienna
Francesco Bertoni
Francesco Bertoni Institute of Oncology Research
Marc Ladanyi
Marc Ladanyi Memorial Sloan Kettering Cancer Center
Emanuele Zucca
Emanuele Zucca Universita della Svizzera Italiana
Katia Scotlandi
Katia Scotlandi Wayne State University
Jeffrey S. Rubin
Jeffrey S. Rubin National Institutes of Health
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Olivier Delattre
Olivier Delattre PSL University

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