What is he best known for?
The fields of study he is best known for:
His scientific interests lie mostly in Stereochemistry, Nuclear magnetic resonance spectroscopy, Protein structure, Transcription factor and Crystallography.
His Stereochemistry research incorporates elements of Hydrolase, Base pair, Organic chemistry and Bacillus circulans.
His studies deal with areas such as Amino acid, Proton NMR and Macromolecule as well as Nuclear magnetic resonance spectroscopy.
His research integrates issues of Proteome and Peptide sequence in his study of Protein structure.
His research in Transcription factor intersects with topics in Plasma protein binding and DNA.
Lawrence P. McIntosh combines subjects such as Antiparallel, Dimer and Heteronuclear molecule with his study of Crystallography.
His most cited work include:
- Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance. (412 citations)
- Genomic and biochemical insights into the specificity of ETS transcription factors. (350 citations)
- Structural proteomics of an archaeon. (268 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of study are Stereochemistry, Nuclear magnetic resonance spectroscopy, Crystallography, Biochemistry and Protein structure.
Lawrence P. McIntosh has researched Stereochemistry in several fields, including Active site, Bacillus circulans, Organic chemistry, Xylanase and Glycoside hydrolase.
In general Nuclear magnetic resonance spectroscopy, his work in Heteronuclear molecule and Nuclear Overhauser effect is often linked to Side chain linking many areas of study.
His Crystallography research focuses on Antiparallel and how it relates to Protein tertiary structure.
In his research on the topic of Biochemistry, DNA, Protein folding, Transcription and Type three secretion system is strongly related with Biophysics.
His work deals with themes such as Plasma protein binding, Protein–protein interaction, Cell biology, Heteronuclear single quantum coherence spectroscopy and Peptide sequence, which intersect with Protein structure.
He most often published in these fields:
- Stereochemistry (35.03%)
- Nuclear magnetic resonance spectroscopy (24.86%)
- Crystallography (19.77%)
What were the highlights of his more recent work (between 2016-2021)?
- Biophysics (16.95%)
- DNA (12.43%)
- Cell biology (12.43%)
In recent papers he was focusing on the following fields of study:
Lawrence P. McIntosh spends much of his time researching Biophysics, DNA, Cell biology, Nuclear magnetic resonance spectroscopy and Stereochemistry.
Lawrence P. McIntosh interconnects Cancer research, Small molecule, Eukaryotic transcription and Molecular dynamics in the investigation of issues within DNA.
His work carried out in the field of Cell biology brings together such families of science as Docking, Protein-fragment complementation assay, Transcription factor, Transactivation and Cooperative binding.
His research investigates the link between Transcription factor and topics such as Transcription that cross with problems in Molecular biology.
His study in Nuclear magnetic resonance spectroscopy is interdisciplinary in nature, drawing from both Peptidoglycan, Plasma protein binding and Active site.
His Stereochemistry research is multidisciplinary, incorporating elements of Nucleophile and Glycoside hydrolase.
Between 2016 and 2021, his most popular works were:
- Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis. (25 citations)
- Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer. (22 citations)
- Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. (22 citations)
In his most recent research, the most cited papers focused on:
His main research concerns Transcription factor, DNA, Cell biology, Biophysics and Linker.
His research brings together the fields of Activator and Transcription factor.
His studies in Cell biology integrate themes in fields like Transcription and AP-1 transcription factor.
His Biophysics research also works with subjects such as
- Protein folding that intertwine with fields like Protein structure,
- Peptide together with Phosphorylation.
He has researched Protein structure in several fields, including Genetics, Signal transduction, Binding site and ETV1.
His study in Linker intersects with areas of studies such as Isothermal titration calorimetry, Serine threonine protein kinase, Stereochemistry, Nuclear magnetic resonance spectroscopy and Transporter.
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