His scientific interests lie mostly in Stereochemistry, Nuclear magnetic resonance spectroscopy, Protein structure, Transcription factor and Crystallography. His Stereochemistry research incorporates elements of Hydrolase, Base pair, Organic chemistry and Bacillus circulans. His studies deal with areas such as Amino acid, Proton NMR and Macromolecule as well as Nuclear magnetic resonance spectroscopy.
His research integrates issues of Proteome and Peptide sequence in his study of Protein structure. His research in Transcription factor intersects with topics in Plasma protein binding and DNA. Lawrence P. McIntosh combines subjects such as Antiparallel, Dimer and Heteronuclear molecule with his study of Crystallography.
His primary areas of study are Stereochemistry, Nuclear magnetic resonance spectroscopy, Crystallography, Biochemistry and Protein structure. Lawrence P. McIntosh has researched Stereochemistry in several fields, including Active site, Bacillus circulans, Organic chemistry, Xylanase and Glycoside hydrolase. In general Nuclear magnetic resonance spectroscopy, his work in Heteronuclear molecule and Nuclear Overhauser effect is often linked to Side chain linking many areas of study.
His Crystallography research focuses on Antiparallel and how it relates to Protein tertiary structure. In his research on the topic of Biochemistry, DNA, Protein folding, Transcription and Type three secretion system is strongly related with Biophysics. His work deals with themes such as Plasma protein binding, Protein–protein interaction, Cell biology, Heteronuclear single quantum coherence spectroscopy and Peptide sequence, which intersect with Protein structure.
Lawrence P. McIntosh spends much of his time researching Biophysics, DNA, Cell biology, Nuclear magnetic resonance spectroscopy and Stereochemistry. Lawrence P. McIntosh interconnects Cancer research, Small molecule, Eukaryotic transcription and Molecular dynamics in the investigation of issues within DNA. His work carried out in the field of Cell biology brings together such families of science as Docking, Protein-fragment complementation assay, Transcription factor, Transactivation and Cooperative binding.
His research investigates the link between Transcription factor and topics such as Transcription that cross with problems in Molecular biology. His study in Nuclear magnetic resonance spectroscopy is interdisciplinary in nature, drawing from both Peptidoglycan, Plasma protein binding and Active site. His Stereochemistry research is multidisciplinary, incorporating elements of Nucleophile and Glycoside hydrolase.
His main research concerns Transcription factor, DNA, Cell biology, Biophysics and Linker. His research brings together the fields of Activator and Transcription factor. His studies in Cell biology integrate themes in fields like Transcription and AP-1 transcription factor.
His Biophysics research also works with subjects such as
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Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance.
D C Muchmore;L P McIntosh;C B Russell;D E Anderson.
Methods in Enzymology (1989)
Genomic and biochemical insights into the specificity of ETS transcription factors.
Peter C. Hollenhorst;Lawrence P. McIntosh;Barbara J. Graves;Barbara J. Graves.
Annual Review of Biochemistry (2011)
Structural proteomics of an archaeon.
Dinesh Christendat;Adelinda Yee;Akil Dharamsi;Yuval Kluger.
Nature Structural & Molecular Biology (2000)
The pKa of the general acid/base carboxyl group of a glycosidase cycles during catalysis: a 13C-NMR study of bacillus circulans xylanase.
Lawrence P. McIntosh;Greg Hand;Philip E. Johnson;Manish D. Joshi.
Biosynthetic incorporation of 15N and 13C for assignment and interpretation of nuclear magnetic resonance spectra of proteins
Lawrence P. McIntosh;Frederick W. Dahlquist.
Quarterly Reviews of Biophysics (1990)
Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase
Manish D. Joshi;Gary Sidhu;Isabelle Pot;Gary D. Brayer.
Journal of Molecular Biology (2000)
Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region
Miles A. Pufall;Gregory M. Lee;Mary L. Nelson;Hyun Seo Kang.
The Transition Between B-DNA and Z-DNA
Thomas M. Jovin;Dikeos M. Soumpasis;Lawrence P. McIntosh.
Annual Review of Physical Chemistry (1987)
An NMR approach to structural proteomics.
Adelinda Yee;Xiaoqing Chang;Antonio Pineda-Lucena;Bin Wu.
Proceedings of the National Academy of Sciences of the United States of America (2002)
Sugar ring distortion in the glycosyl-enzyme intermediate of a family G/11 xylanase.
Gary Sidhu;Stephen G. Withers;Nham T. Nguyen;Lawrence P. McIntosh.
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