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Lawrence P. McIntosh

Lawrence P. McIntosh

D-Index & Metrics

Chemistry

D-Index
57
Citations
11435
World Ranking
11098
National Ranking
302

Overview

Lawrence P. McIntosh is affiliated with the University of British Columbia in Canada. Their research primarily focuses on biochemistry, genetics, and molecular biology, with additional work in medicine. The scientist has contributed extensively to molecular biology and related subfields.

Their research specializes in several main topics including:

  • Genomics and Chromatin Dynamics
  • Monoclonal and Polyclonal Antibodies Research
  • Bacterial Genetics and Biotechnology
  • RNA and Protein Synthesis Mechanisms
  • Salmonella and Campylobacter Epidemiology
  • Escherichia coli Research Studies
  • Cancer-Related Gene Regulation

Frequent publication venues for their work include:

  • Biochemistry
  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Structure
  • SLAS DISCOVERY

The scientist has collaborated frequently with several coauthors, notably:

  • Mark Okon
  • Chloe A. N. Gerak
  • Richard B. Sessions
  • Michel Roberge
  • M.E.P. Murphy

Some recent publications by Lawrence P. McIntosh include:

  • Ligand- and pH-Induced Structural Transition of Gypsy Moth Lymantria dispar Pheromone-Binding Protein 1 (LdisPBP1), 2020, Biochemistry
  • Characterization of the Pilotin-Secretin Complex from the Salmonella enterica Type III Secretion System Using Hybrid Structural Methods, 2020, Structure
  • Peptidoglycan Binding by a Pocket on the Accessory NTF2-domain of Pgp2 Directs Helical Cell Shape of Campylobacter jejuni, 2021, Journal of Biological Chemistry
  • Conformational Plasticity and DNA-Binding Specificity of the Eukaryotic Transcription Factor Pax5, 2021, Biochemistry
  • Biophysical Characterization of the ETV6 PNT Domain Polymerization Interfaces, 2021, Journal of Biological Chemistry

Best Publications

  • Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance.

    D C Muchmore;L P McIntosh;C B Russell;D E Anderson

  • Genomic and biochemical insights into the specificity of ETS transcription factors.

    Peter C. Hollenhorst;Lawrence P. McIntosh;Barbara J. Graves;Barbara J. Graves

  • Arginine: Its pKa value revisited.

    Carolyn A. Fitch;Gerald Platzer;Mark Okon;E Bertrand Garcia-Moreno

  • Structural proteomics of an archaeon.

    Dinesh Christendat;Adelinda Yee;Akil Dharamsi;Yuval Kluger

  • The pKa of the general acid/base carboxyl group of a glycosidase cycles during catalysis: a 13C-NMR study of bacillus circulans xylanase.

    Lawrence P. McIntosh;Greg Hand;Philip E. Johnson;Manish D. Joshi

  • Biosynthetic incorporation of 15N and 13C for assignment and interpretation of nuclear magnetic resonance spectra of proteins

    Lawrence P. McIntosh;Frederick W. Dahlquist

  • Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase

    Manish D. Joshi;Gary Sidhu;Isabelle Pot;Gary D. Brayer

  • Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region

    Miles A. Pufall;Gregory M. Lee;Mary L. Nelson;Hyun Seo Kang

  • The Transition Between B-DNA and Z-DNA

    Thomas M. Jovin;Dikeos M. Soumpasis;Lawrence P. McIntosh

  • An NMR approach to structural proteomics.

    Adelinda Yee;Xiaoqing Chang;Antonio Pineda-Lucena;Bin Wu

  • pH-dependent random coil 1H, 13C, and 15N chemical shifts of the ionizable amino acids: a guide for protein pKa measurements

    Gerald Platzer;Mark Okon;Lawrence P. McIntosh

  • 2D and 3D NMR spectroscopy employing carbon-13/carbon-13 magnetization transfer by isotropic mixing. Spin system identification in large proteins

    Stephen W. Fesik;Hugh L. Eaton;Edward T. Olejniczak;Erik R. P. Zuiderweg

  • Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helix

    Jeannine M. Petersen;Jack J. Skalicky;Logan W. Donaldson;Lawrence P. McIntosh

  • Sugar ring distortion in the glycosyl-enzyme intermediate of a family G/11 xylanase.

    Gary Sidhu;Stephen G. Withers;Nham T. Nguyen;Lawrence P. McIntosh

  • Left-handed DNA: From synthetic polymers to chromosomes.

    Jovin Tm;McIntosh Lp;Arndt-Jovin Dj;Zarling Da

  • Structural features of the epsilon subunit of the Escherichia coli ATP synthase determined by NMR spectroscopy.

    Stephan Wilkens;Frederick W. Dahlquist;Lawrence P. McIntosh;Logan W. Donaldson

  • Solution structure of the ETS domain from murine Ets-1: a winged helix-turn-helix DNA binding motif.

    L. W. Donaldson;J. M. Petersen;B. J. Graves;L. P. McIntosh

  • Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy.

    Terrence G. Oas;Lawrence P. McIntosh;Erin K. O'Shea;Frederick W. Dahlquist

  • Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase.

    Manish D. Joshi;Gary Sidhu;Jens E. Nielsen;Gary D. Brayer

  • Structure of the N-terminal cellulose-binding domain of Cellulomonas fimi CenC determined by nuclear magnetic resonance spectroscopy.

    Philip E. Johnson;Manish D. Joshi;Peter Tomme;Douglas G. Kilburn

  • Three-dimensional 13C-resolved proton NOE spectroscopy of uniformly 13C-labeled proteins for the NMR assignment and structure determination of larger molecules

    Erik R.P Zuiderweg;Lawrence P McIntosh;Frederick W Dahlquist;Stephen W Fesik

  • Arginine: Its pK a value revisited

    Carolyn A. Fitch;Gerald Platzer;Mark Okon;E Bertrand Garcia-Moreno

Frequent Co-Authors

Barbara J. Graves
Barbara J. Graves University of Utah
Stephen G. Withers
Stephen G. Withers University of British Columbia
Natalie C. J. Strynadka
Natalie C. J. Strynadka University of British Columbia
Frederick W. Dahlquist
Frederick W. Dahlquist University of California, Santa Barbara
Aled M. Edwards
Aled M. Edwards Structural Genomics Consortium
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
David S. Wishart
David S. Wishart University of Alberta
Kalle Gehring
Kalle Gehring McGill University
Douglas G. Kilburn
Douglas G. Kilburn University of British Columbia
Michael E. P. Murphy
Michael E. P. Murphy University of British Columbia

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