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Biology and Biochemistry
Poland
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
17773
World Ranking
5659
National Ranking
5

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Poland Leader Award
  • 2025 - Research.com Biology and Biochemistry in Poland Leader Award
  • 2023 - Research.com Biology and Biochemistry in Poland Leader Award
  • 2022 - Research.com Biology and Biochemistry in Poland Leader Award

Overview

Tad A. Holak is affiliated with Jagiellonian University in Poland. Their research spans various topics within medicine and biochemistry, genetics, and molecular biology, with a particular focus on oncology and molecular biology.

Their work involves significant contributions to cancer immunotherapy and biomarkers, CAR-T cell therapy research, and peptidase inhibition and analysis. Other notable research topics include monoclonal and polyclonal antibodies research, ubiquitin and proteasome pathways, click chemistry and its applications, and chemical synthesis and analysis.

Frequent co-authors collaborating with Holak include:

  • Katarzyna Magiera-Mularz
  • Bogdan Musielak
  • Łukasz Skalniak
  • Jacek Plewka
  • Ewa Surmiak

Their publications have appeared most frequently in journals such as:

  • Molecules
  • Journal of Medicinal Chemistry
  • ACS Medicinal Chemistry Letters
  • bioRxiv (Cold Spring Harbor Laboratory)
  • iScience

Recent papers authored or co-authored by Tad A. Holak include:

  • Human and mouse PD-L1: similar molecular structure, but different druggability profiles, 2020, iScience
  • Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction, 2021, Journal of Medicinal Chemistry
  • Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint, 2020, Journal of Medicinal Chemistry
  • Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists, 2021, ACS Medicinal Chemistry Letters
  • Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions, 2020, Angewandte Chemie International Edition

Holak's research centers on immune checkpoint regulation with a strong emphasis on PD-1/PD-L1 interactions and small-molecule inhibitors. Their work integrates organic chemistry approaches with biological evaluation to explore new avenues in cancer immunotherapy.

Best Publications

  • Lifeact: a versatile marker to visualize F-actin

    Julia Riedl;Alvaro H. Crevenna;Kai Kessenbrock;Jerry Haochen Yu

  • Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.

    Krzysztof M. Zak;Radoslaw Kitel;Sara Przetocka;Przemyslaw Golik

  • Filamins: promiscuous organizers of the cytoskeleton

    Grzegorz M. Popowicz;Michael Schleicher;Angelika A. Noegel;Tad A. Holak

  • Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)

    Krzysztof M. Zak;Przemyslaw Grudnik;Katarzyna Guzik;Bartosz J. Zieba

  • Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

    Krzysztof M. Zak;Przemyslaw Grudnik;Katarzyna Magiera;Alexander Dömling

  • Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

    Raphael Stoll;Christian Renner;Silke Hansen;Stefan Palme

  • Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1

    Katarzyna Guzik;Krzysztof M. Zak;Przemyslaw Grudnik;Katarzyna Magiera

  • Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

    Lukasz Skalniak;Krzysztof M Zak;Katarzyna Guzik;Katarzyna Magiera

  • Structure in solution of the major cold-shock protein from Bacillus subtilis.

    A Schnuchel;R Wiltscheck;M Czisch;M Herrler

  • Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery

    Grzegorz M Popowicz;Anna Czarna;Siglinde Wolf;Kan Wang

  • Structure of the stapled p53 peptide bound to Mdm2.

    Sohee Baek;Peter S. Kutchukian;Gregory L. Verdine;Robert Huber

  • Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions.

    Wenzel Kalus;Markus Zweckstetter;Christian Renner;Yolanda Sanchez

  • Expansion of the genetic code enables design of a novel "gold'' class of green fluorescent proteins

    Jae Hyun Bae;Marina Rubini;Gregor Jung;Georg Wiegand

  • Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.

    Grzegorz M. Popowicz;Anna Czarna;Tad A. Holak

  • Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases.

    Thomas Weber;Roland Baumgartner;Christian Renner;Mohamed A Marahiel

  • Mutational analysis of the putative nucleic acid-binding surface of the cold-shock domain, CspB, revealed an essential role of aromatic and basic residues in binding of single-stranded DNA containing the Y-box motif.

    Katja Schröder;Peter Graumann;Arndt Schnuchel;Tad A. Holak

  • RELAXATION MATRIX REFINEMENT OF THE SOLUTION STRUCTURE OF SQUASH TRYPSIN INHIBITOR

    M. Nilges;J. Habazettl;A.T. Brünger;T.A. Holak

  • The Structure-Based Design of Mdm2/Mdmx-p53 Inhibitors Gets Serious

    Grzegorz M. Popowicz;Alexander Dömling;Tad A. Holak

  • Reaction Mechanism of Escherichia coli Dihydrodipicolinate Synthase Investigated by X-ray Crystallography and NMR Spectroscopy†,‡

    Stefan Blickling;Christian Renner;Bernd Laber;Hans-Dieter Pohlenz

  • Protein solubility

    Pawel Smialowski;Antonio J. Martin-Galiano;Aleksandra Mikolajka;Tobias Girschick

Frequent Co-Authors

Alexander Dömling
Alexander Dömling Palacký University, Olomouc
Robert Huber
Robert Huber University of Duisburg-Essen
Angelika A. Noegel
Angelika A. Noegel University of Cologne
Michael Schleicher
Michael Schleicher Ludwig-Maximilians-Universität München
Robert Huber
Robert Huber Agricultural & Applied Economics Association
Richard A. Engh
Richard A. Engh University of Tromsø - The Arctic University of Norway
Michael Czisch
Michael Czisch Max Planck Society
Wolfgang Voelter
Wolfgang Voelter University of Tübingen
Markus Zweckstetter
Markus Zweckstetter German Center for Neurodegenerative Diseases
Rupert Timpl
Rupert Timpl Max Planck Society

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