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Biology and Biochemistry

D-Index
82
Citations
28988
World Ranking
3647
National Ranking
1819

Overview

Javed Khan is affiliated with the National Institutes of Health in the United States. Their research spans key areas in medicine, biochemistry, genetics, and molecular biology, with a total of 199 publications in medicine and 136 in biochemistry, genetics, and molecular biology. Their work also covers several subfields, including molecular biology, oncology, pulmonary and respiratory medicine, cancer research, and computer networks and communications.

Their contributions address a range of scientific topics, with a focus on sarcoma diagnosis and treatment, CAR-T cell therapy research, protein degradation and inhibitors, genomics and chromatin dynamics, neuroblastoma research and treatments, cancer-related molecular mechanisms, and immunotherapy and immune responses.

Javed Khan's recent papers include:

  • Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium, 2021, Journal of Clinical Oncology
  • Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress, 2021, Cancer Cell
  • Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer, 2020, Cell Reports Medicine
  • Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer, 2021, Nature Communications
  • ZFTA Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors, 2021, Cancer Discovery

The scientist has collaborated frequently with several co-authors including Jun S. Wei, Berkley E. Gryder, Young Song, Hsien-Chao Chou, and David Milewski.

Javed Khan's publications appear predominantly in the following venues:

  • Cancer Research (29 publications)
  • Nature Communications (9 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)
  • arXiv (Cornell University) (7 publications)
  • Journal of Clinical Oncology (5 publications)

In addition to journal articles, Javed Khan has contributed to book literature, including a publication with Springer Science+Business Media titled Intelligent Human Computer Interaction (2022).

Best Publications

  • Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

    Javed Khan;Jun S. Wei;Markus Ringnér;Markus Ringnér;Lao H. Saal

  • The genetic landscape of high-risk neuroblastoma

    Trevor J Pugh;Olena Morozova;Edward F Attiyeh;Edward F Attiyeh;Shahab Asgharzadeh;Shahab Asgharzadeh

  • Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

    Yanlin Yu;Javed Khan;Chand Khanna;Lee Helman

  • Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors

    Jack F. Shern;Li Chen;Juliann Chmielecki;Jun S. Wei

  • Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

    Amy P. Hsu;Elizabeth P. Sampaio;Javed Khan;Katherine R. Calvo

  • Gene Expression Profiling of Alveolar Rhabdomyosarcoma with cDNA Microarrays

    Javed Khan;Richard Simon;Michael Bittner;Yidong Chen

  • Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

    Thomas F Eleveld;Derek A Oldridge;Virginie Bernard;Jan Koster

  • The pediatric preclinical testing program: description of models and early testing results.

    Peter J. Houghton;Christopher L. Morton;Chandra Tucker;Debbie Payne

  • International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee.

    PF Ambros;IM Ambros;GM Brodeur;M Haber

  • CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

    Elad Jacoby;Sang M. Nguyen;Thomas J. Fountaine;Kathryn Welp

  • The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation

    Andrew S. Brohl;David A. Solomon;Wendy Chang;Jianjun Wang

  • cDNA Microarrays Detect Activation of a Myogenic Transcription Program by the PAX3-FKHR Fusion Oncogene

    Javed Khan;Michael L. Bittner;Lao H. Saal;Ulrike Teichmann

  • A Hypermorphic Missense Mutation in PLCG2, Encoding Phospholipase Cγ2, Causes a Dominantly Inherited Autoinflammatory Disease with Immunodeficiency

    Qing Zhou;Geun-Shik Lee;Geun-Shik Lee;Jillian Brady;Shrimati Datta

  • Metastasis-associated differences in gene expression in a murine model of osteosarcoma.

    Chand Khanna;Javed Khan;Phoungmai Nguyen;Jennifer Prehn

  • Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial

    Sajid Soofi;Simon Cousens;Saleem P Iqbal;Tauseef Akhund

  • Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.

    James G. Taylor Vi;Adam T. Cheuk;Patricia S. Tsang;Joon-Yong Chung

  • The MYCN oncogene is a direct target of miR-34a.

    Jun Stephen Wei;Young Kook Song;Steffen Durinck;Qing-Rong Chen;Qing-Rong Chen

  • Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents

    Javed A Khan;Xiao Tao;Xiao Tao;Liang Tong

  • DNA microarray technology: The anticipated impact on the study of human disease

    Javed Khan;Michael L. Bittner;Yidong Chen;Paul S. Meltzer

  • Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism

    Derek A. Oldridge;Andrew C. Wood;Nina Weichert-Leahey;Ian Crimmins

Frequent Co-Authors

John M. Maris
John M. Maris Children's Hospital of Philadelphia
Paul S. Meltzer
Paul S. Meltzer National Institutes of Health
Robert C. Seeger
Robert C. Seeger Children's Hospital of Los Angeles
Stephen M. Hewitt
Stephen M. Hewitt National Institutes of Health
Malcolm A. Smith
Malcolm A. Smith National Institutes of Health
Crystal L. Mackall
Crystal L. Mackall Stanford University
Lee J. Helman
Lee J. Helman Children's Hospital of Los Angeles
Jun Wei
Jun Wei The University of Texas MD Anderson Cancer Center
Rimas J. Orentas
Rimas J. Orentas University of Washington
Jeffrey M. Trent
Jeffrey M. Trent Translational Genomics Research Institute

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