World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
12356
World Ranking
14347
National Ranking
6044

Overview

Chi Chen is affiliated with the University of Minnesota in the United States. Their research spans primarily the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology and Genetics as notable subfields. Their work also encompasses Animal Science and Zoology, Physiology, and Plant Science.

The scientist's main topics of research include:

  • Gut microbiota and health
  • Diet and metabolism studies
  • Metabolism and genetic disorders
  • Animal nutrition and physiology
  • Reproductive physiology in livestock
  • Myeloproliferative neoplasms: diagnosis and treatment
  • Meat and animal product quality

Chi Chen has published in several journals, with frequent contributions to:

  • Current Developments in Nutrition
  • Journal of Animal Science
  • Blood
  • Metabolites
  • Acta Oto-Laryngologica

Some of their recent papers include:

  • Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis, 2020, Clinical Gastroenterology and Hepatology
  • Alcohol Production from Carbon Dioxide: Methanol as a Fuel and Chemical Feedstock, 2020, Joule
  • Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis, 2020, Autophagy
  • Feasibility of incorporating recycled fine aggregate in high performance green lightweight engineered cementitious composites, 2020, Journal of Cleaner Production
  • Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity, 2020, International Journal of Obesity

Frequent collaborators in Chi Chen's research include:

  • G. C. Shurson
  • Yiwei Ma
  • Pedro E Urriola
  • Qingqing Mao
  • Baicheng Xu

The breadth of Chi Chen's work crosses multiple disciplines, integrating molecular biology techniques with nutritional and physiological studies primarily related to health, metabolism, and animal science. Their publications reflect a combination of basic and applied research aimed at understanding complex biological systems and their implications for health and agriculture.

Best Publications

  • Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection

    Alexa R. Weingarden;Chi Chen;Aleh Bobr;Dana Yao

  • Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death.

    Chi Chen;Rong Yu;Edward D. Owuor;A. N. Tony Kong

  • Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

    Ah-Ng Kong;Edward Owuor;Rong Yu;Vidya Hebbar

  • Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

    Changjiang Xu;Guoxiang Shen;Chi Chen;Céline Gélinas;Céline Gélinas

  • Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism.

    Rong Yu;Chi Chen;Yin Yuan Mo;Vidya Hebbar

  • Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects.

    Chi Chen;Ah-Ng Tony Kong

  • Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.

    Chi Chen;Daniel Pung;Vasco Leong;Vidya Hebbar

  • Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis

    Ah Ng Tony Kong;Rong Yu;Chi Chen;Sandhya Mandlekar

  • Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells.

    Chi Chen;Guoxiang Shen;Vidya Hebbar;Rong Hu

  • LC-MS-based metabolomics in drug metabolism.

    Chi Chen;Frank J. Gonzalez;Jeffrey R. Idle

  • Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis.

    Limin Shu;Ka Lung Cheung;Tin Oo Khor;Chi Chen

  • Dietary chemopreventive compounds and ARE/EpRE signaling.

    Chi Chen;A.-N.Tony Kong

  • In Vivo Pharmacokinetics and Regulation of Gene Expression Profiles by Isothiocyanate Sulforaphane in the Rat

    Rong Hu;Vidya Hebbar;Bok Ryang Kim;Chi Chen

  • Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation

    Santanu Banerjee;Gregory Sindberg;Fuyuan Wang;Jingjing Meng

  • Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model

    Fuyuan Wang;Jingjing Meng;Li Zhang;Timothy Johnson

  • Serum metabolomics reveals irreversible inhibition of fatty acid β-oxidation through the suppression of PPARα activation as a contributing mechanism of acetaminophen-induced hepatotoxicity

    Chi Chen;Kristopher W. Krausz;Yatrik M. Shah;Jeffrey R. Idle

  • Signal transduction events elicited by cancer prevention compounds

    Ah Ng Tony Kong;Rong Yu;Vidya Hebbar;Chi Chen

  • Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable

    Rong Hu;Tin Oo Khor;Guoxiang Shen;Woo Sik Jeong

  • Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis

    Julia Fritsch;Luis Garces;Maria A. Quintero;Judith Pignac-Kobinger

  • A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse.

    Sarbani Giri;Sarbani Giri;Jeffrey R. Idle;Chi Chen;T. Mark Zabriskie

Frequent Co-Authors

Gerald C Shurson
Gerald C Shurson University of Minnesota
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Roger Ruan
Roger Ruan University of Minnesota
Jeffrey R. Idle
Jeffrey R. Idle University of Bern
Kristopher W. Krausz
Kristopher W. Krausz National Institutes of Health
Paul Chen
Paul Chen University of Minnesota
Brian J. Kerr
Brian J. Kerr Agricultural Research Service
Ah-Ng Tony Kong
Ah-Ng Tony Kong Rutgers, The State University of New Jersey
Lee J Johnston
Lee J Johnston University of Minnesota
Yatrik M. Shah
Yatrik M. Shah University of Michigan–Ann Arbor

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