The scientist’s investigation covers issues in Debrisoquine, Internal medicine, Pharmacology, Genetics and Biochemistry. His studies in Debrisoquine integrate themes in fields like Debrisoquin, Polymorphism and Hydroxylation. The concepts of his Internal medicine study are interwoven with issues in Gastroenterology, Endocrinology and Pathology.
His work on Acetaminophen as part of general Pharmacology research is frequently linked to In patient, bridging the gap between disciplines. His Genetics research focuses on Molecular biology and how it connects with Humanized mouse, Peptide sequence and COS cells. His research investigates the link between Biochemistry and topics such as Metabolomics that cross with problems in Transcriptome, Lipid metabolism, Toxicity and Physiology.
His primary scientific interests are in Pharmacology, Internal medicine, Endocrinology, Biochemistry and Metabolite. Jeffrey R. Idle has included themes like Metabolism, Toxicity, Debrisoquine and Hydroxylation in his Pharmacology study. Jeffrey R. Idle usually deals with Debrisoquine and limits it to topics linked to Allele and Genotype, Restriction fragment length polymorphism and Genotyping.
His Internal medicine research is multidisciplinary, incorporating perspectives in Pharmacogenetics and Oncology. He interconnects Peroxisome proliferator-activated receptor, Trimethylamine and Nicotine in the investigation of issues within Endocrinology. His Metabolite study incorporates themes from Urine, Chromatography and Nifedipine.
The scientist’s investigation covers issues in Metabolomics, Biochemistry, Pharmacology, Internal medicine and Endocrinology. His Metabolomics research incorporates themes from Metabolite, Urine, Tandem mass spectrometry and Xenobiotic. His study looks at the relationship between Metabolite and fields such as Metabolism, as well as how they intersect with chemical problems.
His Pharmacology research integrates issues from Pregnane X receptor and Toxicity. Internal medicine is frequently linked to Gastroenterology in his study. His Endocrinology research incorporates elements of Biomarker, Peroxisome proliferator-activated receptor, Fatty acid, Liver disease and Peroxisome.
Metabolomics, Biochemistry, Pharmacology, Internal medicine and Metabolite are his primary areas of study. Jeffrey R. Idle combines subjects such as Pimelic acid, Urine, Xanthine and Metabolism with his study of Metabolomics. His biological study spans a wide range of topics, including Tandem mass spectrometry and Mass spectrometry.
His studies deal with areas such as Pregnane X receptor and Toxicity as well as Pharmacology. His Internal medicine research includes themes of Gastroenterology and Endocrinology. Jeffrey R. Idle has researched Drug metabolism in several fields, including Phenacetin, Polymorphism, Debrisoquine, Hydroxylation and Xenobiotic.
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Polymorphic hydroxylation of debrisoquine in man
A Mahgoub;L.G Dring;J.R Idle;R Lancaster.
The Lancet (1977)
A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.
D A Evans;A Mahgoub;T P Sloan;J R Idle.
Journal of Medical Genetics (1980)
Nomenclature for human CYP2D6 alleles.
A K Daly;J Brockmoller;F Broly;M Eichelbaum.
Metabolic oxidation phenotypes as markers for susceptibility to lung cancer
Riad Ayesh;Jeffrey R. Idle;James C. Ritchie;Michael J. Crothers.
The role of individual human cytochromes P450 in drug metabolism and clinical response.
Suzanne Cholerton;Ann K. Daly;Jeffrey R. Idle.
Trends in Pharmacological Sciences (1992)
Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy.
Hirokazu Furuya;Pedro Fernandez-salguero;Wendy Gregory;Heather Taber.
Metabolism of melatonin by human cytochromes p450.
Xiaochao Ma;Jeffrey R Idle;Kristopher W Krausz;Frank J Gonzalez.
Drug Metabolism and Disposition (2005)
Mutant debrisoquine hydroxylation genes in Parkinson's disease
M. Armstrong;A.K. Daly;S. Cholerton;J.R. Idle.
The Lancet (1992)
Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology
Vidar M. Steen;Ole A. Andreassen;Ann K. Daly;Toril Tefre.
Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.
R R Shah;N S Oates;J R Idle;R L Smith.
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