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Medicine
Sweden
2023

D-Index & Metrics

Medicine

D-Index
107
Citations
34717
World Ranking
6338
National Ranking
132

Research.com Recognitions

  • 2023 - Research.com Medicine in Sweden Leader Award

Overview

Leif Bertilsson is affiliated with Karolinska University Hospital in Sweden and conducts research primarily in the fields of Pharmacology, Toxicology, Pharmaceutics, and Medicine. Their work spans subfields such as Pharmacology and Oncology, focusing on topics related to Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Drug-Induced Hepatotoxicity and Protection, as well as Cancer Treatment and Pharmacology.

Their recent publications include the following papers:

  • Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug-Drug Interaction in Healthy Volunteers, 2021, Journal of Personalized Medicine
  • Tribute to Folke Sjöqvist, a Pioneer in Clinical Pharmacology, 2020, Clinical Pharmacology & Therapeutics

Frequent co-authors collaborating with Leif Bertilsson are:

  • Xueqing Li
  • Roslyn Thelingwani
  • Ulf Diczfalusy
  • Tommy B. Andersson
  • Collen Masimirembwa

Leif Bertilsson's publications have appeared in the following venues:

  • Journal of Personalized Medicine
  • Clinical Pharmacology & Therapeutics

The research carried out by Bertilsson covers multiple aspects of drug metabolism and pharmacology at molecular and clinical levels, including biomarkers for enzyme activity related to drug interactions, and contributions to the understanding of clinical pharmacology history.

Best Publications

  • A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.

    Sarah C. Sim;Sarah C. Sim;Carl Risinger;Carl Risinger;Marja‐Liisa Dahl;Marja‐Liisa Dahl;Eleni Aklillu;Eleni Aklillu

  • "Serotonin depression"--a biochemical subgroup within the affective disorders?

    Marie Åsberg;Peter Thorén;Lil Traskman;Leif Bertilsson

  • Monoamine metabolites in CSF and suicidal behavior.

    Lil Träskman;Marie Åsberg;Leif Bertilsson;Lars Sjüstrand

  • Clomipramine Treatment of Obsessive-Compulsive Disorder: II. Biochemical Aspects

    Peter Thorén;Marie Åsberg;Leif Bertilsson;Britt Mellström

  • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

    Inger Johansson;Eva Lundqvist;Leif Bertilsson;Marja-Liisa Dahl

  • Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs

    Leif Bertilsson;Marja-Liisa Dahl;Per Dalén;Ayman Al-Shurbaji

  • Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19.

    Leif Bertilsson

  • Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

    I. Johansson;M. Oscarson;Qun-Ying Yue;L. Bertilsson

  • Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin.

    Leif Bertilsson;Ya‐Qing Lou;Yun‐Long Du;Yin Liu

  • Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.

    E Aklillu;I Persson;L Bertilsson;I Johansson

  • Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

    M L Dahl;I Johansson;L Bertilsson;M Ingelman-Sundberg

  • Homicide, suicide and CSF 5‐HIAA

    L. Lidberg;J. R. Tuck;Marie Åsberg;G. P. Scalia-Tomba

  • 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes.

    Per Dalén;Marja-Liisa Dahl;Maria Luisa Bernal Ruiz;Jan Nordin

  • Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.

    L Bertilsson;JA Carrillo;ML Dahl;A Llerena

  • CSF monoamine metabolites in melancholia.

    Marie Åsberg;L. Bertilsson;B. Mårtensson;G. P. Scalia-Tomba

  • Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide. An update

    Leif Bertilsson;Torbjörn Tomson

  • Platelet MAO activity and monoamine metabolites in cerebrospinal fluid in depressed and suicidal patients and in healthy controls

    Lars Oreland;Åsa Wiberg;Marie Åsberg;Lil Träskman

  • CSF 5-HIAA Predicts Suicide Risk after Attempted Suicide.

    Peter Nordström;Mats Samuelsson;Marie Åsberg;Lil Träskman‐Bendz

  • Pharmacokinetics of indomethacin

    Gunnar Alván;Michael Orme;Leif Bertilsson;Roger Ekstrand

  • Indoleamine metabolites in the cerebrospinal fluid of depressed patients before and during treatment with nortriptyline

    Marie Åsberg;Leif Bertilsson;Dick Tuck;Börje Cronholm

Frequent Co-Authors

Marja-Liisa Dahl
Marja-Liisa Dahl Karolinska University Hospital
Folke Sjöqvist
Folke Sjöqvist Karolinska Institute
Magnus Ingelman-Sundberg
Magnus Ingelman-Sundberg Karolinska Institute
Inger Johansson
Inger Johansson Karolinska Institute
Ulf Diczfalusy
Ulf Diczfalusy Karolinska University Hospital
Torbjörn Tomson
Torbjörn Tomson Karolinska Institute
Tommy B. Andersson
Tommy B. Andersson AstraZeneca (United Kingdom)
Ernst Brodin
Ernst Brodin Karolinska Institute
Michel Eichelbaum
Michel Eichelbaum University of Tübingen
Anders Rane
Anders Rane Karolinska University Hospital

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