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Overview

Jose de Leon is affiliated with the University of Kentucky in the United States and is active in the field of medicine, with a primary focus on psychiatry and mental health. Their research encompasses several subfields, including pharmacology, pediatrics, perinatology and child health, toxicology, and clinical psychology.

The scientist's work addresses a range of topics, prominently featuring schizophrenia research and treatment, bipolar disorder and treatment, pharmacogenetics and drug metabolism, pharmacovigilance and adverse drug reactions, pharmacological effects and toxicity studies, treatment of major depression, and electroconvulsive therapy studies.

Among Jose de Leon's recent scholarly papers are:

  • An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels (2021) published in Pharmacopsychiatry
  • Clinimetric Criteria for Patient-Reported Outcome Measures (2021) published in Psychotherapy and Psychosomatics
  • A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology (2020) published in Psychotherapy and Psychosomatics
  • Clozapine is strongly associated with the risk of pneumonia and inflammation (2020) published in General Psychiatry
  • Pneumonia may be more frequent and have more fatal outcomes with clozapine than with other second-generation antipsychotics (2020) published in World Psychiatry

The scientist frequently publishes in several key venues, including:

  • Schizophrenia Research
  • Expert Opinion on Drug Metabolism & Toxicology
  • Journal of Clinical Psychopharmacology
  • Revista de Psiquiatría y Salud Mental
  • Revista de Psiquiatría y Salud Mental (English Edition)

Jose de Leon collaborates regularly with a number of coauthors, most notably:

  • Carlos De las Cuevas
  • Georgios Schoretsanitis
  • Can-Jun Ruan
  • Emílio J. Sanz
  • Hélène Verdoux

Best Publications

  • A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors

    Jose de Leon;Francisco J. Diaz

  • Pharmacogenetics and Pharmacogenomics of Schizophrenia: A Review of Last Decade of Research

    Maria Arranz;J de Leon

  • Are there more than two syndromes in schizophrenia? A critique of the positive-negative dichotomy.

    V Peralta;J de Leon;M J Cuesta

  • The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation.

    Jose de Leon;Margaret T. Susce;Run-Mei Pan;Maureen Fairchild

  • Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19.

    Jose de Leon;Scott C. Armstrong;Scott C. Armstrong;Kelly L. Cozza;Kelly L. Cozza

  • Polydipsia and water intoxication in psychiatric patients: A review of the epidemiological literature

    Jose de Leon;Cherian Verghese;Joseph I. Tracy;Richard C. Josiassen

  • Metabolic drug interactions with newer antipsychotics: a comparative review.

    Edoardo Spina;Jose de Leon

  • Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness.

    Wen Hwei Chou;F.-X. Yan;J. De Leon;J. Barnhill

  • Suicide attempts and impulsivity

    Enrique Baca-Garcia;Carmen Diaz-Sastre;Eloy García Resa;Hilario Blasco

  • The AmpliChip CYP450 genotyping test: Integrating a new clinical tool.

    Jose de Leon;Margaret T. Susce;Elaina Murray-Carmichael

  • Tobacco smoking behaviors in bipolar disorder: a comparison of the general population, schizophrenia, and major depression.

    Francisco J Diaz;Danielle James;Sheila Botts;Lorraine Maw

  • Initiation of daily smoking and nicotine dependence in schizophrenia and mood disorders.

    Jose de Leon;Francisco J Diaz;Thea Rogers;Debra Browne

  • The association between high nicotine dependence and severe mental illness may be consistent across countries.

    Jose De Leon;Elisardo Becona;Manuel Gurpegui;Ana Gonzalez-Pinto

  • Smoking and Vulnerability for Schizophrenia

    J de Leon

  • A pilot study on risperidone metabolism : The role of cytochromes P450 2D6 and 3A

    J A Bork;T Rogers;P J Wedlund;J de Leon

  • Nicotine dependence and symptoms in schizophrenia: naturalistic study of complex interactions.

    M. Carmen Aguilar;Manuel Gurpegui;Francisco J. Diaz;Jose De Leon

  • Gene-Specific Involvement of β-Oxidation in Wound-Activated Responses in Arabidopsis

    M. Cruz Castillo;Cristina Martínez;Antony Buchala;Jean-Pierre Métraux

  • Suicide attempts in bipolar patients.

    P. López;Fernando Mosquera;J. de León;M. Gutiérrez

  • Tobacco Smoking and Bipolar Disorder

    Ana Gonzalez-Pinto;Miguel Gutierrez;Jesus Ezcurra;Felipe Aizpuru

  • Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy

    Jacob T. Brown;Jeffrey R. Bishop;Katrin Sangkuhl;Erika L. Nurmi

Frequent Co-Authors

Enrique Baca-García
Enrique Baca-García Autonomous University of Madrid
Edoardo Spina
Edoardo Spina University of Messina
M. Mercedes Perez-Rodriguez
M. Mercedes Perez-Rodriguez Icahn School of Medicine at Mount Sinai
John M. Kane
John M. Kane Zucker Hillside Hospital
Ana González-Pinto
Ana González-Pinto University of the Basque Country
Maria A. Oquendo
Maria A. Oquendo University of Pennsylvania
Peter A. Crooks
Peter A. Crooks University of Arkansas for Medical Sciences
Manuel J. Cuesta
Manuel J. Cuesta Hospital Universitario de Navarra
Thomas B. Cooper
Thomas B. Cooper Columbia University
Maria Arranz
Maria Arranz King's College London

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