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Medicine

D-Index
78
Citations
18292
World Ranking
18184
National Ranking
733

Overview

Edoardo Spina is affiliated with the University of Messina in Italy and has contributed extensively to the field of medicine, with a focus on psychiatry, pharmacology, pediatrics, oncology, and surgery. Their research emphasizes several key areas including schizophrenia research and treatment, treatment of major depression, pharmaceutical studies and practices, bipolar disorder and treatment, pharmacovigilance and adverse drug reactions, biosimilars and bioanalytical methods, and epilepsy research and treatment.

Spina has published papers in a variety of academic journals with notable recurring appearances in such venues as:

  • Pharmaceuticals
  • CNS & Neurological Disorders - Drug Targets
  • Neuroscience Applied
  • Expert Opinion on Drug Metabolism & Toxicology
  • Frontiers in Pharmacology

Recent research publications by Spina include:

  • "An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels" (2021), published in Pharmacopsychiatry
  • "COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety" (2021), published in Drug Safety
  • "Safety profiles of biologic agents for inflammatory bowel diseases: a prospective pharmacovigilance study in Southern Italy" (2020), published in Current Medical Research and Opinion
  • "An update on the complex relationship between clozapine and pneumonia" (2021), published in Expert Review of Clinical Pharmacology
  • "A Narrative Review on Efficacy and Safety of Proton Pump Inhibitors in Children" (2022), published in Frontiers in Pharmacology

Frequent co-authors collaborating with Spina include:

  • María Antonietta Barbieri
  • Giuseppe Cicala
  • Paola Maria Cutroneo
  • José de León
  • Georgios Schoretsanitis

Spina's work spans multiple subfields of medicine, prominently including:

  • Psychiatry and Mental health
  • Pharmacology
  • Pediatrics, Perinatology and Child Health
  • Oncology
  • Surgery

The scientist's research also addresses topics of clinical and pharmaceutical relevance, focusing particularly on:

  • Schizophrenia research and treatment
  • Treatment of Major Depression
  • Pharmaceutical studies and practices
  • Bipolar Disorder and Treatment
  • Pharmacovigilance and Adverse Drug Reactions
  • Biosimilars and Bioanalytical Methods
  • Epilepsy research and treatment

Best Publications

  • CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages.

    J Kirchheiner;K Brosen;Marja-Liisa Dahl;LF Gram

  • Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: An update

    Edoardo Spina;Vincenza Santoro;Concetta D'Arrigo

  • CLINICALLY SIGNIFICANT PHARMACOKINETIC DRUG INTERACTIONS WITH CARBAMAZEPINE: AN UPDATE

    Edoardo Spina;Franco Pisani;Emilio Perucca

  • Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance

    Maria Gabriella Scordo;Maria Gabriella Scordo;Maria Gabriella Scordo;Vittorio Pengo;Vittorio Pengo;Vittorio Pengo;Edoardo Spina;Edoardo Spina;Edoardo Spina;Marja Liisa Dahl;Marja Liisa Dahl;Marja Liisa Dahl

  • Metabolic drug interactions with newer antipsychotics: a comparative review.

    Edoardo Spina;Jose de Leon

  • Antiepileptic drugs: indications other than epilepsy

    Edoardo Spina;Giulio Perugi

  • Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population.

    Maria Gabriella Scordo;Maria Gabriella Scordo;Eleni Aklillu;Umit Yasar;Marja-Liisa Dahl

  • Allele and genotype frequencies of CYP2C9, CYP2C19 and CYP2D6 in an Italian population.

    Maria Gabriella Scordo;Achille P Caputi;Concetta D'Arrigo;Giuseppina Fava

  • Quetiapine and clozapine in parkinsonian patients with dopaminergic psychosis

    Letterio Morgante;Antonio Epifanio;Edoardo Spina;Mario Zappia

  • Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone.

    Maria Gabriella Scordo;Edoardo Spina;Gabriella Facciolà;Angela Avenoso

  • Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics

    Edoardo Spina;Angela Avenoso;Gabriella Facciolà;Maria G. Scordo

  • Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes.

    Norio Yasui-Furukori;Mats Hidestrand;Edoardo Spina;Gabriella Facciolá

  • Clinically significant drug interactions with newer antidepressants.

    Edoardo Spina;Gianluca Trifirò;Filippo Caraci

  • Metabolic drug interactions with new psychotropic agents.

    Edoardo Spina;Maria Gabriella Scordo;Concetta D'Arrigo

  • Clinically significant drug interactions with antidepressants in the elderly.

    Edoardo Spina;Maria Gabriella Scordo

  • Effect of fluvoxamine on the pharmacokinetics of imipramine and desipramine in healthy subjects.

    E. Spina;A. M. Pollicino;A. Avenoso;G. M. Campo

  • Plasma Concentrations of Risperidone and 9-Hydroxyrisperidone: Effect of Comedication With Carbamazepine or Valproate

    Edoardo Spina;Angela Avenoso;Gabriella Facciolà;Monica Salemi

  • The economic burden of preventable adverse drug reactions: a systematic review of observational studies

    D Formica;J Sultana;P M Cutroneo;S Lucchesi

  • Clinical applications of CYP genotyping in psychiatry.

    Edoardo Spina;Jose de Leon;Jose de Leon;Jose de Leon

  • Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interaction.

    Edoardo Spina;Angela Avenoso;Maria Gabriella Scordo;Maria Ancione

Frequent Co-Authors

Jose de Leon
Jose de Leon University of Kentucky
Achille P. Caputi
Achille P. Caputi University of Messina
Emilio Perucca
Emilio Perucca University of Pavia
Marja-Liisa Dahl
Marja-Liisa Dahl Karolinska University Hospital
Alessandro Serretti
Alessandro Serretti Kore University of Enna
Placido Bramanti
Placido Bramanti University of Messina
Fortunato Battaglia
Fortunato Battaglia Seton Hall University
Edoardo Ferlazzo
Edoardo Ferlazzo Magna Graecia University
Siegfried Kasper
Siegfried Kasper Medical University of Vienna
Umberto Aguglia
Umberto Aguglia Magna Graecia University

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