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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
10932
World Ranking
13293
National Ranking
5656

Overview

Mischa Machius is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research primarily spans Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology as the main subfield of study. Additional areas include Immunology, Oncology, Plant Science, and Infectious Diseases.

The scientist's work covers several main topics, including:

  • Glycosylation and Glycoproteins Research
  • Phagocytosis and Immune Regulation
  • Chemical Synthesis and Analysis
  • Amoebic Infections and Treatments
  • Pancreatitis Pathology and Treatment
  • Bone and Dental Protein Studies
  • Neurological diseases and metabolism

Machius has published numerous papers in a variety of scientific venues. Frequent publication platforms include UNC Libraries, OPAL (Open@LaTrobe) at La Trobe University, Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), and Structure.

Selected recent papers demonstrating the range of their research include:

  • Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges, 2021, Structure
  • Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes, 2020, Journal of Molecular Biology
  • Chemically targeting the redox switch in AP1 transcription factor ΔFOSB, 2022, Nucleic Acids Research
  • TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis, 2020, UNC Libraries
  • Designer molecules of the synaptic organizer MDGA1 reveal 3D conformational control of biological function, 2023, Journal of Biological Chemistry

The scientist's frequent collaborators include Shanghua Fan, Gabby Rudenko, Michael J. Miley, Brian Kuhlman, and Ashwani Kumar.

Best Publications

  • Three-dimensional structure of the complexin/SNARE complex.

    Xiaocheng Chen;Diana R. Tomchick;Evguenii Kovrigin;Demet Araç

  • Crystal structure of calcium-depleted Bacillus licheniformis alpha-amylase at 2.2 A resolution.

    M. Machius;G. Wiegand;R. Huber

  • Pivotal role of water in the mechanism of P450BM-3.

    Donovan C. Haines;Diana R. Tomchick;Mischa Machius;Julian A. Peterson

  • Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain

    Takanori Otomo;Diana R. Tomchick;Chinatsu Otomo;Sanjay C. Panchal

  • Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase

    Maojun Yang;Christian B. Gocke;Xuelian Luo;Dominika Borek

  • Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.

    Chad A. Brautigam;Barbara S. Smith;Zhiquan Ma;Maya Palnitkar

  • Structural Basis of Rho Gtpase-Mediated Activation of the Formin Mdia1

    Takanori Otomo;Chinatsu Otomo;Diana R. Tomchick;Mischa Machius

  • Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor

    Thomas H. Scheuermann;Diana R. Tomchick;Mischa Machius;Yan Guo;Yan Guo

  • Activation of Bacillus licheniformis α-amylase through a disorder→order transition of the substrate-binding site mediated by a calcium–sodium–calcium metal triad

    Mischa Machius;Nathalie Declerck;Robert Huber;Georg Wiegand

  • Crystal structure of a 12 ANK repeat stack from human ankyrinR

    Peter Michaely;Diana R. Tomchick;Mischa Machius;Richard G.W. Anderson

  • Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine.

    Maojun Yang;Jeffrey C. Culhane;Lawrence M. Szewczuk;Pegah Jalili

  • Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

    Ok Ho Shin;Jun Lu;Jun Lu;Jun Lu;Jeong Seop Rhee;Jeong Seop Rhee;Jeong Seop Rhee;Diana R. Tomchick

  • p31comet blocks Mad2 activation through structural mimicry.

    Maojun Yang;Bing Li;Diana R. Tomchick;Mischa Machius

  • Side chain and backbone contributions of Phe508 to CFTR folding.

    Patrick H Thibodeau;Chad A Brautigam;Mischa Machius;Philip J Thomas

  • Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

    Maojun Yang;Jeffrey C Culhane;Lawrence M Szewczuk;Christian B Gocke

  • Probing structural determinants specifying high thermostability in Bacillus licheniformis alpha-amylase.

    Nathalie Declerck;Mischa Machius;Georg Wiegand;Robert Huber

  • Hyperthermostabilization of Bacillus licheniformis α-amylase and modulation of its stability over a 50°C temperature range

    Nathalie Declerck;Mischa Machius;Philippe Joyet;Georg Wiegand

  • The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation

    Janice C. Jones;Jeffrey W. Duffy;Mischa Machius;Brenda R. S. Temple

  • Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1.

    Bingke Yu;Ilídio R.S. Martins;Ilídio R.S. Martins;Pilong Li;Gaya K. Amarasinghe

  • Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain

    D.R. Tomchick;T. Otomo;C. Otomo;S.C. Panchal

Frequent Co-Authors

Diana R. Tomchick
Diana R. Tomchick The University of Texas Southwestern Medical Center
Chad A. Brautigam
Chad A. Brautigam The University of Texas Southwestern Medical Center
Josep Rizo
Josep Rizo The University of Texas Southwestern Medical Center
Robert Huber
Robert Huber Agricultural & Applied Economics Association
David T. Chuang
David T. Chuang The University of Texas Southwestern Medical Center
Thomas C. Südhof
Thomas C. Südhof Stanford University
Michael K. Rosen
Michael K. Rosen The University of Texas Southwestern Medical Center
Michael V. Norgard
Michael V. Norgard The University of Texas Southwestern Medical Center
Hongtao Yu
Hongtao Yu The University of Texas Southwestern Medical Center
Stephen V. Frye
Stephen V. Frye University of North Carolina at Chapel Hill

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