D-Index & Metrics Best Publications
Research.com 2022 Best Female Scientist Award Badge

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Best female scientists D-index 139 Citations 62,824 516 World Ranking 154 National Ranking 102
Biology and Biochemistry D-index 136 Citations 61,185 451 World Ranking 223 National Ranking 161

Research.com Recognitions

Awards & Achievements

2022 - Research.com Best Female Scientist Award

2020 - Fellow of the Royal Society, United Kingdom

2018 - Nobel Prize for the directed evolution of enzymes

2014 - Fellow, National Academy of Inventors

2011 - Fellow of the American Academy of Arts and Sciences

2009 - Fellow of the American Association for the Advancement of Science (AAAS)

2008 - Member of the National Academy of Sciences

2001 - Fellow of the Indian National Academy of Engineering (INAE)

2000 - Member of the National Academy of Engineering For integration of fundamentals in molecular biology, genetics, and bioengineering to the benefit of life science and industry.

Overview

What is she best known for?

The fields of study she is best known for:

  • Enzyme
  • Gene
  • DNA

Frances H. Arnold mainly investigates Directed evolution, Biochemistry, Genetics, Protein engineering and Computational biology. Her Directed evolution study integrates concerns from other disciplines, such as Biocatalysis, Thermostability and Biochemical engineering. Her study looks at the intersection of Biochemistry and topics like Bacillus subtilis with Mutant.

Sequence alignment, Mutagenesis and Protein folding is closely connected to Protein structure in her research, which is encompassed under the umbrella topic of Genetics. The Protein engineering study combines topics in areas such as Sequence, Peptide sequence, Artificial intelligence, Machine learning and Process. Her Computational biology study incorporates themes from Fitness landscape, Selection and Function.

Her most cited work include:

  • Dynamic pattern formation in a vesicle-generating microfluidic device. (1736 citations)
  • A Microfabricated Fluorescence-Activated Cell Sorter (1013 citations)
  • A synthetic multicellular system for programmed pattern formation (980 citations)

What are the main themes of her work throughout her whole career to date?

Her primary scientific interests are in Directed evolution, Biochemistry, Enzyme, Stereochemistry and Protein engineering. Her Directed evolution research includes themes of Biocatalysis, Computational biology and Biochemical engineering. Her Biocatalysis research focuses on Catalysis and how it relates to Combinatorial chemistry and Molecule.

Frances H. Arnold combines subjects such as Enantioselective synthesis, Cyclopropanation, Substrate, Cytochrome P450 and Carbene with her study of Stereochemistry. Her studies in Cytochrome P450 integrate themes in fields like Heme and Hydroxylation. Her Protein engineering study frequently links to adjacent areas such as Protein structure.

She most often published in these fields:

  • Directed evolution (33.65%)
  • Biochemistry (25.38%)
  • Enzyme (20.19%)

What were the highlights of her more recent work (between 2017-2021)?

  • Directed evolution (33.65%)
  • Stereochemistry (20.19%)
  • Biocatalysis (10.58%)

In recent papers she was focusing on the following fields of study:

Frances H. Arnold mainly focuses on Directed evolution, Stereochemistry, Biocatalysis, Combinatorial chemistry and Carbene. Frances H. Arnold has included themes like Fitness landscape, Protein engineering, Mutation and Biochemical engineering in her Directed evolution study. Her work on Indole test as part of general Stereochemistry study is frequently linked to Pyrococcus furiosus, bridging the gap between disciplines.

As a part of the same scientific study, she usually deals with the Biocatalysis, concentrating on Active site and frequently concerns with Enzyme catalysis and Protonation. Her Combinatorial chemistry research is multidisciplinary, incorporating elements of Reagent, Catalysis, Enantioselective synthesis, Nitrene and Enzyme. Her Carbene research incorporates themes from Cyclopropanation, Substrate, Selectivity, Enantiomer and Hemeprotein.

Between 2017 and 2021, her most popular works were:

  • Directed Evolution: Bringing New Chemistry to Life. (402 citations)
  • Machine-learning-guided directed evolution for protein engineering. (226 citations)
  • Machine learning-assisted directed protein evolution with combinatorial libraries. (170 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Dynamic pattern formation in a vesicle-generating microfluidic device.

Todd Thorsen;Richard W. Roberts;Frances H. Arnold;Stephen R. Quake.
Physical Review Letters (2001)

2368 Citations

A microfabricated fluorescence-activated cell sorter

Anne Y. Fu;Charles Spence;Axel Scherer;Frances H. Arnold.
Nature Biotechnology (1999)

1412 Citations

A synthetic multicellular system for programmed pattern formation

Subhayu Basu;Yoram Gerchman;Cynthia H. Collins;Frances H. Arnold.
Nature (2005)

1236 Citations

Molecular evolution by staggered extension process (StEP) in vitro recombination

Huimin Zhao;Lori Giver;Zhixin Shao;Joseph A. Affholter.
Nature Biotechnology (1998)

1182 Citations

Protein stability promotes evolvability.

Jesse D. Bloom;Sy T. Labthavikul;Christopher R. Otey;Frances H. Arnold.
Proceedings of the National Academy of Sciences of the United States of America (2006)

1145 Citations

Engineering microbial consortia: a new frontier in synthetic biology.

Katie Brenner;Lingchong You;Frances H. Arnold.
Trends in Biotechnology (2008)

929 Citations

Programmed population control by cell-cell communication and regulated killing.

Lingchong You;Robert Sidney Cox;Ron Weiss;Frances H. Arnold.
Nature (2004)

854 Citations

Exploring protein fitness landscapes by directed evolution

Philip A. Romero;Frances H. Arnold.
Nature Reviews Molecular Cell Biology (2009)

853 Citations

Why highly expressed proteins evolve slowly

D. Allan Drummond;Jesse D. Bloom;Christoph Adami;Christoph Adami;Claus O. Wilke;Claus O. Wilke.
Proceedings of the National Academy of Sciences of the United States of America (2005)

830 Citations

Design by Directed Evolution

Frances H. Arnold.
Accounts of Chemical Research (1998)

792 Citations

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