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Barbara A. Leggett

Barbara A. Leggett

D-Index & Metrics

Medicine

D-Index
89
Citations
27747
World Ranking
12735
National Ranking
415

Overview

Barbara A. Leggett is affiliated with the University of Queensland in Australia, focusing on medicine with a specialization in hepatology, oncology, epidemiology, molecular biology, and pathology and forensic medicine. Their work encompasses a strong emphasis on liver disease diagnosis and treatment, genetic factors in colorectal cancer, liver disease and transplantation, hepatitis C virus research, colorectal cancer treatments and studies, epigenetics and DNA methylation, and colorectal cancer screening and detection.

Leggett has contributed to the scientific community through numerous publications in various venues. Frequent publication outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Journal of Gastroenterology and Hepatology
  • The Medical Journal of Australia
  • Digestive Diseases and Sciences

Some recent papers authored or co-authored by Leggett are:

  • "Seladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study" (2023), published in Hepatology
  • "Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment" (2021), published in Clinical Cancer Research
  • "APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers" (2020), published in Cancers
  • "Diabetes mellitus and the progression of non-alcoholic fatty liver disease to decompensated cirrhosis: a retrospective cohort study" (2023), published in The Medical Journal of Australia
  • "Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease" (2020), published in Human Pathology

Leggett's collaborative network features frequent co-authors including:

  • Vicki Whitehall
  • Alexandra Kane
  • Diane McKeone
  • Catherine Bond
  • Cheng Liu

Best Publications

  • CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.

    Daniel J Weisenberger;Kimberly D Siegmund;Mihaela Campan;Joanne Young

  • Role of the serrated pathway in colorectal cancer pathogenesis.

    Barbara Leggett;Vicki Whitehall;Vicki Whitehall

  • Immunohistochemistry Versus Microsatellite Instability Testing in Phenotyping Colorectal Tumors

    Noralane M. Lindor;Lawrence J. Burgart;Olga Leontovich;Richard M. Goldberg

  • Whole-genome landscape of pancreatic neuroendocrine tumours

    Aldo Scarpa;David K. Chang;Katia Nones;Katia Nones;Vincenzo Corbo

  • BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

    T Kambara;L A Simms;V L J Whitehall;K J Spring

  • Emerging concepts in colorectal neoplasia

    Jeremy R. Jass;Vicki L.J. Whitehall;Joanne Young;Barbara A. Leggett

  • High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy

    Kevin J. Spring;Zhen Zhen Zhao;Rozemary Karamatic;Michael D. Walsh

  • Morphology of sporadic colorectal cancer with DNA replication errors

    J. R. Jass;Kim-Anh Do;L. A. Simms;H. Iino

  • The serrated pathway to colorectal carcinoma: current concepts and challenges.

    Mark Bettington;Mark Bettington;Neal Walker;Andrew Clouston;Ian Brown

  • Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours

    R. F. Souza;R. Appel;J. Yin;S. Wang

  • Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis.

    Joanne Young;Lisa A. Simms;Kelli G. Biden;Coral Wynter

  • Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers

    Laura Baglietto;Noralane M. Lindor;James G. Dowty;Darren M. White

  • DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?

    H Iino;J R Jass;L A Simms;J Young

  • Metachronous Colorectal Cancer Risk for Mismatch Repair Gene Mutation Carriers: The Advantage of More Extensive Colon Surgery

    Susan Parry;Susan Parry;Aung Ko Win;Bryan Parry;Finlay A Macrae

  • Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways.

    Jeremy R. Jass;Kelli G. Biden;Margaret C. Cummings;Lisa A. Simms

  • Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability.

    Vicki L. J. Whitehall;Michael D. Walsh;Joanne Young;Barbara A. Leggett

  • Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum

    J. R. Jass;H. Iino;A. Ruszkiewicz;D. Painter

  • Germline Mutations in BMPR1A/ALK3 Cause a Subset of Cases of Juvenile Polyposis Syndrome and of Cowden and Bannayan-Riley-Ruvalcaba Syndromes

    Xiao-Ping Zhou;Kelly Woodford-Richens;Rainer Lehtonen;Keisuke Kurose

  • Colorectal Cancer With Mutation in BRAF, KRAS, and Wild-Type With Respect to Both Oncogenes Showing Different Patterns of DNA Methylation

    Takeshi Nagasaka;Hiromi Sasamoto;Kenji Notohara;Harry M. Cullings

  • Cancer Risks for MLH1 and MSH2 Mutation Carriers

    James G Dowty;Aung K Win;Daniel D Buchanan;Noralane M Lindor

Frequent Co-Authors

Joanne P. Young
Joanne P. Young University of Adelaide
Jeremy R. Jass
Jeremy R. Jass Imperial College London
Michael Walsh
Michael Walsh Memorial Sloan Kettering Cancer Center
Beth Newman
Beth Newman Queensland University of Technology
Stephen J. Meltzer
Stephen J. Meltzer Johns Hopkins University School of Medicine
Joanne F. Aitken
Joanne F. Aitken Cancer Council Queensland
Daniel D. Buchanan
Daniel D. Buchanan University of Melbourne
Lawrie W. Powell
Lawrie W. Powell University of Queensland
Nicola Waddell
Nicola Waddell QIMR Berghofer Medical Research Institute
Grant W. Montgomery
Grant W. Montgomery University of Queensland

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