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D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
32376
World Ranking
9434
National Ranking
4160

Research.com Recognitions

  • 2018 - National Institutes of Health Director's Pioneer Award
  • 2017 - Eppendorf & Science Prize for Neurobiology Gradinaru is developing optogenetics, tissue clearing, and viral vectors to probe circuits underlying locomotion, reward, and sleep.
  • 2015 - Fellow of Alfred P. Sloan Foundation

Overview

Viviana Gradinaru is affiliated with the California Institute of Technology in the United States. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with notable contributions in medicine. Key subfields include molecular biology, genetics, neurology, cellular and molecular neuroscience, and physiology.

Their work covers several main topics:

  • Virus-based gene therapy research
  • CRISPR and genetic engineering
  • RNA interference and gene delivery
  • Neuroinflammation and neurodegeneration mechanisms
  • RNA regulation and disease
  • Alzheimer's disease research and treatments
  • Parkinson's disease mechanisms and treatments

They have multiple frequently cited recent papers, including:

  • "Negative feedback control of neuronal activity by microglia" (2020), published in Nature
  • "Tissue clearing and its applications in neuroscience" (2020), published in Nature Reviews. Neuroscience
  • "LRP1 is a master regulator of tau uptake and spread" (2020), published in Nature
  • "Molecular basis of astrocyte diversity and morphology across the CNS in health and disease" (2022), published in Science
  • "A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice" (2020), published in eLife

Frequent co-authors of Viviana Gradinaru include:

  • Xinhong Chen
  • Xiaozhe Ding
  • Sarkis K. Mazmanian
  • Timothy F. Shay
  • Sripriya Ravindra Kumar

Their publications have appeared most often in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Caltech Institute Archives (California Institute of Technology)
  • SSRN Electronic Journal
  • Neuron
  • Cell Reports

Awards granted to this scientist include the National Institutes of Health Director's Pioneer Award in 2018, the Eppendorf & Science Prize for Neurobiology in 2017 with the citation noting development of optogenetics, tissue clearing, and viral vectors for circuit studies, and fellowship status from the Alfred P. Sloan Foundation received in 2015.

Best Publications

  • Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

    Timothy R. Sampson;Justine W. Debelius;Taren Thron;Stefan Janssen

  • Structural and molecular interrogation of intact biological systems

    Kwanghun Chung;Jenelle Wallace;Sung Yon Kim;Sandhiya Kalyanasundaram

  • Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

    Ken Y. Chan;Min J. Jang;Bryan B. Yoo;Alon Greenbaum

  • Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

    Viviana Gradinaru;Feng Zhang;Charu Ramakrishnan;Joanna Mattis

  • Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

    Bin Yang;Jennifer B. Treweek;Rajan P. Kulkarni;Rajan P. Kulkarni;Benjamin E. Deverman

  • Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

    Tommaso Patriarchi;Jounhong Ryan Cho;Katharina Merten;Mark W. Howe

  • Negative feedback control of neuronal activity by microglia

    Ana Badimon;Hayley J. Strasburger;Pinar Ayata;Xinhong Chen

  • Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

    Benjamin E. Deverman;Piers L. Pravdo;Bryan P. Simpson;Sripriya Ravindra Kumar

  • Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures.

    Feng Zhang;Viviana Gradinaru;Antoine Roger Adamantidis;Remy Durand

  • Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

    Joanna Mattis;Kay M Tye;Emily A Ferenczi;Charu Ramakrishnan

  • Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

    Jin Hyung Lee;Remy Durand;Viviana Gradinaru;Feng Zhang

  • Dynamics of Retrieval Strategies for Remote Memories

    Inbal Goshen;Matthew Brodsky;Rohit Prakash;Jenelle Wallace

  • eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications

    Viviana Gradinaru;Kimberly R. Thompson;Karl Deisseroth

  • Targeting and Readout Strategies for Fast Optical Neural Control In Vitro and In Vivo

    Viviana Gradinaru;Kimberly R. Thompson;Feng Zhang;Murtaza Mogri

  • Tissue clearing and its applications in neuroscience

    Hiroki R. Ueda;Ali Ertürk;Kwanghun Chung;Viviana Gradinaru

  • Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning

    Ilana B. Witten;Shih Chun Lin;Matthew Brodsky;Rohit Prakash

  • LRP1 is a master regulator of tau uptake and spread

    Jennifer N. Rauch;Gabriel Luna;Elmer Guzman;Morgane Audouard

  • Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex.

    William E. Allen;Isaac V. Kauvar;Michael Z. Chen;Ethan B. Richman

  • Bioelectronic medicines: a research roadmap.

    Karen Birmingham;Viviana Gradinaru;Polina Anikeeva;Warren M. Grill

  • Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

    Min Pan;Michael A. Reid;Xazmin H. Lowman;Rajan P. Kulkarni;Rajan P. Kulkarni

Frequent Co-Authors

Karl Deisseroth
Karl Deisseroth Stanford University
Frances H. Arnold
Frances H. Arnold California Institute of Technology
Charu Ramakrishnan
Charu Ramakrishnan Stanford University
Hongkui Zeng
Hongkui Zeng Allen Institute for Brain Science
Ed S. Lein
Ed S. Lein University of Washington
Bosiljka Tasic
Bosiljka Tasic Allen Institute for Brain Science
Jonathan T. Ting
Jonathan T. Ting Allen Institute for Brain Science
Sarkis K. Mazmanian
Sarkis K. Mazmanian California Institute of Technology
Scott L. Delp
Scott L. Delp Stanford University

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